Volume 21 Issue 12
Dec.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(12): 2074-2076
ZHANG Xia, XU Xiaomin. Correlation between uterine artery SD, THBS1 and coagulation dysfunction in pregnant women with pre-eclampsia[J]. Chinese Journal of General Practice, 2023, 21(12): 2074-2076. doi: 10.16766/j.cnki.issn.1674-4152.003293
Citation: ZHANG Xia, XU Xiaomin. Correlation between uterine artery SD, THBS1 and coagulation dysfunction in pregnant women with pre-eclampsia[J]. Chinese Journal of General Practice, 2023, 21(12): 2074-2076. doi: 10.16766/j.cnki.issn.1674-4152.003293
shu

Correlation between uterine artery SD, THBS1 and coagulation dysfunction in pregnant women with pre-eclampsia

doi: 10.16766/j.cnki.issn.1674-4152.003293
  • 1.

    Department of Obstetrics and Gynaecology, Zhoushan Women' s and Children' s Hospital, Zhoushan, Zhejiang 316000, China

Funds:

 LQ21H040007

 2023C1307

  • Received Date: 2023-08-22
    Abstract
  •   Objective  To explore the relationship that may help in the treatment of pre-eclampsia by measuring the peak systolic flow rate/end-diastolic flow rate (SD) of uterine arteries in pregnant women with pre-eclampsia, platelet thrombin protein 1 (THBS1), and changes in coagulation indices.  Methods  A total of 60 cases of pregnant women with pre-eclampsia who received consultation and treatment at the Obstetrics Department of Zhoushan Women' s and Children' s Hospital from March 1, 2020 to May 31, 2022 were randomly selected as study subjects. According to the condition, there were 25 cases in the mild group and 35 cases in the severe group, and 60 cases of healthy pregnant women were selected as the control group. The levels of uterine artery SD, THBS1 and coagulation function indexes were determined. The relationship between uterine artery SD, THBS1 and coagulation function and the influencing of patients' coagulation dysfunction were analyzed.  Results  As the worsened, the patients' SD and D-Dimer (D-D) levels were significantly increased, THBS1 levels were significantly decreased, and prothrombin time (PT) and trombin time (TT) were significantly shortened (all P < 0.05). On Pearson' s analysis, SD was negatively correlated with PT (r=-0.627, P=0.014) and TT (r=-0.412, P=0.023), and positively correlated with D-D (r=0.556, P=0.030); THBS1 was positively correlated with PT (r=0.833, P=0.001) and TT (r=0.680, P=0.008), and negatively correlated with D-D (r=-0.324, P=0.037). Logistic analysis, increased SD and increased SD were the patients with pre-eclampsia who developed coagulation dysfunction independent risk factors, and increased THBS1, prolonged PT, and prolonged TT were independent protective factors (all P < 0.05).  Conclusion  Pregnant women with pre-eclampsia have abnormal uterine artery SD, THBS1, coagulation function, and there is a significant relationship between these indicators, which are expected to become indicators for assessing coagulation dysfunction in patients.

     

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