Volume 21 Issue 12
Dec.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(12): 2074-2076
ZHANG Xia, XU Xiaomin. Correlation between uterine artery SD, THBS1 and coagulation dysfunction in pregnant women with pre-eclampsia[J]. Chinese Journal of General Practice, 2023, 21(12): 2074-2076. doi: 10.16766/j.cnki.issn.1674-4152.003293
Citation: ZHANG Xia, XU Xiaomin. Correlation between uterine artery SD, THBS1 and coagulation dysfunction in pregnant women with pre-eclampsia[J]. Chinese Journal of General Practice, 2023, 21(12): 2074-2076. doi: 10.16766/j.cnki.issn.1674-4152.003293
shu

Correlation between uterine artery SD, THBS1 and coagulation dysfunction in pregnant women with pre-eclampsia

doi: 10.16766/j.cnki.issn.1674-4152.003293
  • 1.

    Department of Obstetrics and Gynaecology, Zhoushan Women' s and Children' s Hospital, Zhoushan, Zhejiang 316000, China

Funds:

 LQ21H040007

 2023C1307

  • Received Date: 2023-08-22
    Abstract
  •   Objective  To explore the relationship that may help in the treatment of pre-eclampsia by measuring the peak systolic flow rate/end-diastolic flow rate (SD) of uterine arteries in pregnant women with pre-eclampsia, platelet thrombin protein 1 (THBS1), and changes in coagulation indices.  Methods  A total of 60 cases of pregnant women with pre-eclampsia who received consultation and treatment at the Obstetrics Department of Zhoushan Women' s and Children' s Hospital from March 1, 2020 to May 31, 2022 were randomly selected as study subjects. According to the condition, there were 25 cases in the mild group and 35 cases in the severe group, and 60 cases of healthy pregnant women were selected as the control group. The levels of uterine artery SD, THBS1 and coagulation function indexes were determined. The relationship between uterine artery SD, THBS1 and coagulation function and the influencing of patients' coagulation dysfunction were analyzed.  Results  As the worsened, the patients' SD and D-Dimer (D-D) levels were significantly increased, THBS1 levels were significantly decreased, and prothrombin time (PT) and trombin time (TT) were significantly shortened (all P < 0.05). On Pearson' s analysis, SD was negatively correlated with PT (r=-0.627, P=0.014) and TT (r=-0.412, P=0.023), and positively correlated with D-D (r=0.556, P=0.030); THBS1 was positively correlated with PT (r=0.833, P=0.001) and TT (r=0.680, P=0.008), and negatively correlated with D-D (r=-0.324, P=0.037). Logistic analysis, increased SD and increased SD were the patients with pre-eclampsia who developed coagulation dysfunction independent risk factors, and increased THBS1, prolonged PT, and prolonged TT were independent protective factors (all P < 0.05).  Conclusion  Pregnant women with pre-eclampsia have abnormal uterine artery SD, THBS1, coagulation function, and there is a significant relationship between these indicators, which are expected to become indicators for assessing coagulation dysfunction in patients.

     

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    • References(18)
  • [1]
    MA' AYEH M, COSTANTINE M M. Prevention of preeclampsia[J]. Semin Fetal Neonatal Med, 2020, 25(5): 101123. DOI: 10.1016/j.siny.2020.101123.
    [2]
    储华, 陆艳, 刘明松. 孕期子宫动脉超声参数动态分析与子痫前期风险的相关性研究[J]. 中华全科医学, 2022, 20(9): 1545-1547, 1582. doi: 10.16766/j.cnki.issn.1674-4152.002645

    CHU H, LU Y, LIU M S. The correlation between the dynamic analysis of uterine artery ultrasound parameters during pregnancy and the risk of preeclampsia[J]. Chinese Journal of General Practice, 2022, 20(9): 1545-1547, 1582. doi: 10.16766/j.cnki.issn.1674-4152.002645
    [3]
    NIRUPAMA R, DIVYASHREE S, JANHAVI P, et al. Preeclampsia: pathophysiology and management[J]. J Gynecol Obstet Hum Reprod, 2021, 50(2): 101975. DOI: 10.1016/j.jogoh.2020.101975.
    [4]
    赵花, 田玲, 沈禾, 等. 凝血功能指标及血小板参数与子痫前期的相关性研究[J]. 蚌埠医学院学报, 2020, 45(7): 883-887.

    ZHAO H, TIAN L, SHEN H, et al. Correlation between coagulation function, platelet parameters and preeclampsia[J]. Journal of Bengbu Medical College, 2020, 45(7): 883-887.
    [5]
    王玮, 高华, 陆芬芳, 等. 血管阻力及子宫动脉血流参数预测早期妊娠期高血压疾病并发先兆子痫的效能分析[J]. 中国妇幼保健, 2023, 38(2): 234-237.

    WANG W, GAO H, LU F F, et al. Analysis of the efficacy of vascular resistance and uterine artery blood flow parameters in predicting early hypertensive disorders of pregnancy complicated by preeclampsia[J]. Maternal and Child Health Care of China, 2023, 38(2): 234-237.
    [6]
    李方, 韩秋峪, 孙礼强, 等. 血清TSP-1、VEGF及TSP-1/VEGF与早发型重度子痫前期发病的相关性及预测的临床价值[J]. 医学研究杂志, 2022, 51(5): 136-140.

    LI F, HAN Q Y, SUN L Q, et al. Clinical Value and Correlation of Serum TSP-1, VEGF and TSP-1/VEGF with the Incidence of Early-onset Severe Preeclampsia[J]. Journal of Medical Research, 2022, 51(5): 136-140.
    [7]
    TSAKIRIDIS I, GIOULEKA S, ARVANITAKI A, et al. Gestational hypertension and preeclampsia: an overview of national and international guidelines[J]. Obstet Gynecol Surv, 2021, 76(10): 613-633. doi: 10.1097/OGX.0000000000000942
    [8]
    王姊文, 符平. 超声测定子痫前期孕妇心肌功能指数与子宫动脉血流搏动指数, 子宫动脉阻力指数的相关性及联合预测胎盘早剥的价值[J]. 中国性科学, 2021, 30(10): 91-95.

    WANG Z W, FU P. The correlation between Tei index anduterine artery pulsatility index, uterine artery resistance index measured by ultrasound in pregnant women with preeclampsia and the value of combined prediction of placental abruption[J]. Chinese Journal of Human Sexuality, 2021, 30(10): 91-95.
    [9]
    TEMUR M, SERPIM G, TUTUZLUOǦLU S, et al. Comparison of serum human pregnancy-specific beta-1-glycoprotein 1 levels in pregnant women with or without preeclampsia[J]. J Obstet Gynaecol, 2020, 40(8): 1074-1078. doi: 10.1080/01443615.2019.1679734
    [10]
    OVERTON E, TOBES D, LEE A. Preeclampsia diagnosis and management[J]. Best Pract Res Clin Anaesthesiol, 2022, 36(1): 107-121. doi: 10.1016/j.bpa.2022.02.003
    [11]
    邓晨晨, 陶峰, 陈红波. 子宫动脉多普勒超声预测子痫前期的研究现状[J]. 中华全科医学, 2020, 18(6): 1002-1005. doi: 10.16766/j.cnki.issn.1674-4152.001413

    DENG C C, TAO F, CHEN H B. Prediction of uterine artery doppler for preeclampsia[J]. Chinese Journal of General Practice, 2020, 18(6): 1002-1005. doi: 10.16766/j.cnki.issn.1674-4152.001413
    [12]
    高海洋, 齐欣. 妊娠期高血压疾病: 母亲的当下和未来[J]. 临床内科杂志, 2021, 38(1): 1-4.

    GAO H Y, QI X. Hypertension disorders in pregnancy: maternal dilemma and future perspectives[J]. Journal of Clinical Internal Medicine, 2021, 38(1): 1-4.
    [13]
    吴少君, 王琳. 孕中晚期子痫前期患者血清抗米勒管激素、整合素β1水平与子宫螺旋动脉血流参数及血管内皮细胞损伤指标的相关性[J]. 中国计划生育学杂志, 2022, 30(9): 2120-2123.

    WU S J, WANG L. Correlation between the levels of serum anti-mullerian hormone and integrinβ-1 of pregnant women with preeclampsia during the second and the third trimester of pregnancy and their uterine spiral artery blood flow parameters and vascular endothelial cell injury indictors[J]. Chinese Journal of Family Planning, 2022, 30(9): 2120-2123.
    [14]
    褚翠雯, 陈爱萍, 李坤. 超声子宫动脉血流指标评估子痫前期孕妇母胎循环及与妊娠结局的相关性[J]. 中国计划生育学杂志, 2022, 30(7): 1569-1573.

    CHU C W, CHEN A P, LI K. Maternal and fetal circulation situation evaluated by the uterine artery blood flow indexes of ultrasonography and their cor-relation with the pregnancy outcomes[J]. Chinese Journal of Family Planning, 2022, 30(7): 1569-1573.
    [15]
    牛三强, 刘宁, 刘梅, 等. 子痫前期孕妇胎盘组织中miR-377-3p、血小板凝血酶蛋白1 mRNA表达分析[J]. 山东医药, 2023, 63(20): 64-67.

    NIU S Q, LIU N, LIU M, et al. Analysis of miR-377-3p and platelet thromboplastin 1 mRNA expression in placental tissues of pregnant women with preeclampsia[J]. Shandong Medical Journal, 2023, 63(20): 64-67.
    [16]
    XU C, LI Y H, ZHANG W, et al. Analysis of perinatal coagulation function in preeclampsia[J]. Medicine (Baltimore), 2021, 100(26): e26482. DOI: 10.1097/MD.0000000000026482.
    [17]
    黎俊伶, 庞小玩, 丁燕玲, 等. 血栓弹力图在子痫前期凝血功能变化监测中的意义分析[J]. 广西医科大学学报, 2022, 39(11): 1806-1810.

    LAI J L, PANG X W, DING Y L, et al. Significance of thromboelastography in monitoring coagulation function in preeclampsia[J]. Journal of Guangxi Medical University, 2022, 39(11): 1806-1810.
    [18]
    刘佳栋, 雷文佳. 凝血功能指标、血栓前状态与子痫前期发病的关系[J]. 岭南心血管病杂志, 2020, 26(1): 67-69, 78.

    LIU J D, LEI W J. Relationship between coagulation function index, prethrombotic state and preeclampsia[J]. South China Journal of Cardiovascular Diseases, 2020, 26(1): 67-69, 78.
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