Research progress on the cGAS-STING pathway in the kidney disease

HAN Zhenyuan; WANG Xiaoyan

doi:10.16766/j.cnki.issn.1674-4152.003304

Volume 21 Issue 12

Dec. 2023

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HAN Zhenyuan, WANG Xiaoyan. Research progress on the cGAS-STING pathway in the kidney disease[J]. Chinese Journal of General Practice, 2023, 21(12): 2119-2123. doi: 10.16766/j.cnki.issn.1674-4152.003304

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HAN Zhenyuan, WANG Xiaoyan. Research progress on the cGAS-STING pathway in the kidney disease[J]. Chinese Journal of General Practice, 2023, 21(12): 2119-2123. doi: 10.16766/j.cnki.issn.1674-4152.003304

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Research progress on the cGAS-STING pathway in the kidney disease

doi: 10.16766/j.cnki.issn.1674-4152.003304

HAN Zhenyuan¹
, WANG Xiaoyan^{1, 2
,
,}

1.
Department of Nephrology, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu 210019, China

Funds:

81970605

Received Date: 2023-06-08
Available Online: 2024-01-29

Abstract

Abstract

As an important component of the innate immune system, the cyclic guanosine monophosphate-adenosine monophosphate synthase stimulator of interferon genes (cGAS-STING) signaling pathway plays a critical role in mediating immune responses by inducing the secretion of type Ⅰ interferons and inflammatory cytokines. The cGAS-STING pathway activates interferon regulatory factor 3 or nuclear factor-κB and is involved in inflammation, infection, cellular homeostasis, obesity and organ fibrosis. In addition, the role of the cGAS-STING pathway in common kidney diseases is increasingly appreciated by clinical and basic researchers. Recent studies have shown that activation of the cGAS-STING pathway in acute kidney injury can trigger the release of inflammatory factors and exacerbate inflammation. This abnormal activation of the pathway is closely linked to the development and progression of kidney fibrosis in chronic kidney disease. In addition, the cGAS-STING pathway also plays an important role in kidney cancer. The cGAS-STING pathway is therefore a promising target for the treatment of kidney diseases. However, more research is needed to fully understand the specific mechanisms and therapeutic potential of the cGAS-STING pathway in kidney disease. In order to provide clinicians and researchers with new perspectives, this paper reviews recent research progress on the cGAS-STING pathway in common kidney diseases, discusses the role of this pathway in the pathogenesis of acute kidney injury, chronic kidney disease and renal cancer, and highlights the potential of this pathway as an effective therapeutic target, especially for acute kidney injury, in an attempt to provide new insights and approaches for the treatment of kidney diseases.

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References

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Research progress on the cGAS-STING pathway in the kidney disease

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