Volume 21 Issue 12
Dec.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(12): 2169-2172
SHAO Xiaoxiao, SHI Ruixin, FANG Ye, WANG Weizhong, JIANG Yi. Ustekinumab in the treatment of stenosis Crohn's disease: A case report and literature review[J]. Chinese Journal of General Practice, 2023, 21(12): 2169-2172. doi: 10.16766/j.cnki.issn.1674-4152.003315
Citation: SHAO Xiaoxiao, SHI Ruixin, FANG Ye, WANG Weizhong, JIANG Yi. Ustekinumab in the treatment of stenosis Crohn's disease: A case report and literature review[J]. Chinese Journal of General Practice, 2023, 21(12): 2169-2172. doi: 10.16766/j.cnki.issn.1674-4152.003315
shu

Ustekinumab in the treatment of stenosis Crohn's disease: A case report and literature review

doi: 10.16766/j.cnki.issn.1674-4152.003315
  • 1.

    Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

Funds:

 Y2020285

 19331101

  • Received Date: 2023-03-28
    Available Online: 2024-01-29
    Abstract
  • Crohn's disease (CD) is a chronic granulomatous disease of unknown etiology that can affect any part of the alimentary tract from the mouth to the anus. CD is often accompanied by a variety of complications, such as intestinal lumen stenosis, intestinal fistula, abscess and perforation. Intestinal lumen stenosis is the most common complication, and there is still a lack of effective methods for the radical treatment of CD intestinal lumen stenosis. Recent studies have found that ustekinumab (UST) attenuates chronic inflammation-associated stenosis in the intestinal tract of CD patients by inhibiting IL-12 and IL-23-mediated cell signaling, activation, and downstream inflammatory cytokine production. In this paper, a case of CD complicated with intestinal stenosis admitted to the Second Affiliated Hospital of Wenzhou Medical University was treated with UST and achieved good therapeutic effect. The case is reported as follows and relevant literature is reviewed.

     

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