Volume 22 Issue 1
Jan.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(1): 30-33
YANG Dongdong, ZHAO Meng, DU Jiaxiu, SHI Yu. COL1A2 as a diagnostic and predictive marker in osteoarthritis and the immune infiltration mechanism of osteoarthritis[J]. Chinese Journal of General Practice, 2024, 22(1): 30-33. doi: 10.16766/j.cnki.issn.1674-4152.003324
Citation: YANG Dongdong, ZHAO Meng, DU Jiaxiu, SHI Yu. COL1A2 as a diagnostic and predictive marker in osteoarthritis and the immune infiltration mechanism of osteoarthritis[J]. Chinese Journal of General Practice, 2024, 22(1): 30-33. doi: 10.16766/j.cnki.issn.1674-4152.003324
shu

COL1A2 as a diagnostic and predictive marker in osteoarthritis and the immune infiltration mechanism of osteoarthritis

doi: 10.16766/j.cnki.issn.1674-4152.003324
  • 1.

    Department of Neurology, the Fifth Clinical College of Henan University of Traditional Chinese Medicine (Zhengzhou People' s Hospital), Zhengzhou, Henan 450053, China

Funds:

 LHGJ20220 785

 2019A1 515110739

  • Received Date: 2023-03-06
    Available Online: 2024-03-09
    Abstract
  •   Objective  Osteoarthritis (OA) is a common degenerative joint disease, but its pathogenesis remains largely unclear. This study aimed to explore the key diagnostic markers and immune microenvironment involved in the development of OA, in order to provide references and assistance for diagnosis and treatment strategies of OA.  Methods  Gene expression datasets GSE169077 and GSE55235 from Gene expression omnibus (GEO) database were analyzed to identify key diagnostic marker genes and detect immune cell infiltration in OA.  Results  A total of 402 differentially expressed genes were obtained, including 230 up-regulated genes and 172 down-regulated genes. After screening and verification, COL1A2 was identified as a key diagnostic marker gene. Analysis of immune cell infiltration showed that neutrophils, dendritic cells, NK cells, T cells, monocytes and macrophages were highly expressed in the OA immune microenvironment.  Conclusion  This study finds that COL1A2 gene may be a key diagnostic marker for OA. COL1A2 may exert biological effects through extracellular matrix (ECM) receptor pathway, focal adhesion (FA) signaling pathway, etc. Neutrophils, dendritic cells, NK cells, T cells and other immune cells play an important role in the immune microenvironment changes of OA. The results help to further understand the pathogenesis of OA and provide a reference for diagnosis and treatment.

     

    • FullText(HTML)
  • loading
    • References(23)
  • [1]
    ABRAMOFF B, CALDERA F E. Osteoarthritis: pathology, diagnosis, and treatment options[J]. Med Clin North Am, 2020, 104(2): 293-311. doi: 10.1016/j.mcna.2019.10.007
    [2]
    YAO Q, WU X, TAO C, et al. Osteoarthritis: pathogenic signaling pathways and therapeutic targets[J]. Signal Transduct Tar, 2023, 8(1): 56. doi: 10.1038/s41392-023-01330-w
    [3]
    秦夕茹, 张立智. 骨关节炎疼痛的机制[J]. 中华全科医学, 2021, 19(6): 1001-1007. doi: 10.16766/j.cnki.issn.1674-4152.001971

    QIN X R, ZHANG L Z. Mechanisms of osteoarthritis pain[J]. Chinese Journal of General Practice, 2021, 19(6): 1001-1007. doi: 10.16766/j.cnki.issn.1674-4152.001971
    [4]
    POULSEN R C, JAIN L, DALBETH N. Re-thinking osteoarthritis pathogenesis: what can we learn (and what do we need to unlearn) from mouse models about the mechanisms involved in disease development[J]. Arthritis Res Ther, 2023, 25(1): 59. doi: 10.1186/s13075-023-03042-6
    [5]
    NEDUNCHEZHIYAN U, VARUGHESE I, SUN A R, et al. Obesity, inflammation, and immune system in osteoarthritis[J]. Front Immunol, 2022, 13: 907750. DOI: 10.3389/fimmu.2022.907750.
    [6]
    GIORGINO R, ALBANO D, FUSCO S, et al. Knee osteoarthritis: epidemiology, pathogenesis, and mesenchymal stem cells: what else is new? An update[J]. Int J Mol Sci, 2023, 24(7): 6405. doi: 10.3390/ijms24076405
    [7]
    WANG X, WEN D, YOU C, et al. Comprehensive analysis of immune cell infiltration and role of MSR1 expression in aneurysmal subarachnoid haemorrhage[J]. Cell Proliferation, 2023, 56(6): e13379. DOI: 10.1111/cpr.13379.
    [8]
    WOETZEL D, HUBER R, KUPFER P, et al. Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation[J]. Arthritis Res Ther, 2014, 16(2): R84. DOI: 10.1186/ar4526.
    [9]
    MOORE J E, PURCARO M J, PRATT H E, et al. Expanded encyclopaedias of DNA elements in the human and mouse genomes[J]. Nature, 2020, 583(7818): 699-710. doi: 10.1038/s41586-020-2493-4
    [10]
    WANG S, WU R, LU J, et al. Protein-protein interaction networks as miners of biological discovery[J]. Proteomics, 2022, 22(15-16): e2100190. DOI: 10.1002/pmic.202100190.
    [11]
    ENGEBRETSEN S, BOHLIN J. Statistical predictions with glmnet[J]. Clin Epigenetics, 2019, 11(1): 123. doi: 10.1186/s13148-019-0730-1
    [12]
    VINA E R, KWOH C K. Epidemiology of osteoarthritis: literature update[J]. Curr Opin Rheumatol, 2018, 30(2): 160. doi: 10.1097/BOR.0000000000000479
    [13]
    王健, 李志军. 骨关节炎的诊断与治疗[J]. 中华全科医学, 2020, 18(3): 347-348. http://www.zhqkyx.net/article/id/3a39a47b-c02d-4940-890f-de96249c6c2d

    WANG J, LI Z J. Diagnosis and treatment of osteoarthritis[J]. Chinese Journal of General Practice, 2020, 18(3): 347-348. http://www.zhqkyx.net/article/id/3a39a47b-c02d-4940-890f-de96249c6c2d
    [14]
    OWCZARZY A, KURASIŃSKI R, KULIG K, et al. Collagen-structure, properties and application[J]. Eng Biomater, 2020, 23(156): 17-23.
    [15]
    GIBBON A, RALEIGH S M, RIBBANS W J, et al. Functional COL1A1 variants are associated with the risk of acute musculoskeletal soft tissue injuries[J]. J Orthop Res, 2020, 38(10): 2290-2298. doi: 10.1002/jor.24621
    [16]
    RAI M F, TYCKSEN E D, CAI L, et al. Distinct degenerative phenotype of articular cartilage from knees with meniscus tear compared to knees with osteoarthritis[J]. Osteoarthr Cartilage, 2019, 27(6): 945-955. doi: 10.1016/j.joca.2019.02.792
    [17]
    SANCHEZ-LOPEZ E, CORAS R, TORRES A, et al. Synovial inflammation in osteoarthritis progression[J]. Nat Rev Rheumatol, 2022, 18(5): 258-275. doi: 10.1038/s41584-022-00749-9
    [18]
    RAPP A E, ZAUCKE F. Cartilage extracellular matrix-derived matrikines in osteoarthritis[J]. Am J Physiol Cell Physiol, 2023, 324(2): C377-C394. doi: 10.1152/ajpcell.00464.2022
    [19]
    SUN K, LUO J, GUO J, et al. The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review[J]. Osteoarthr Cartilage, 2020, 28(4): 400-409. doi: 10.1016/j.joca.2020.02.027
    [20]
    WOODELL-MAY J E, SOMMERFELD S D. Role of inflammation and the immune system in the progression of osteoarthritis[J]. J Orthop Res, 2020, 38(2): 253-257. doi: 10.1002/jor.24457
    [21]
    TRAJEROVA M, KRIEGOVA E, MIKULKOVA Z, et al. Knee osteoarthritis phenotypes based on synovial fluid immune cells correlate with clinical outcome trajectories[J]. Osteoarthr Cartilage, 2022, 30(12): 1583-1592. doi: 10.1016/j.joca.2022.08.019
    [22]
    LOUKOV D, KARAMPATOS S, MALY M, et al. Monocyte activation is elevated in women with knee-osteoarthritis and associated with inflammation, BMI and pain[J]. Osteoarthr Cartilage, 2018, 26(2): 255-263. doi: 10.1016/j.joca.2017.10.018
    [23]
    TAO R, FAN X X, YU H J, et al. MicroRNA-29b-3p prevents Schistosoma japonicum-induced liver fibrosis by targeting COL1A1 and COL3A1[J]. J Cell Biochem, 2018, 119(4): 3199-3209. doi: 10.1002/jcb.26475
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(5)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (116) PDF downloads(10) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return