Volume 22 Issue 1
Jan.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(1): 34-38
ZHENG Kesong, KANG Fang, HAN Mingming, YANG Chengwei, HUANG Xiang, LI Juan. A comparative study on the effect of different anesthesia methods on early postoperative inflammatory indicators and rehabilitation in patients undergoing cesarean section[J]. Chinese Journal of General Practice, 2024, 22(1): 34-38. doi: 10.16766/j.cnki.issn.1674-4152.003325
Citation: ZHENG Kesong, KANG Fang, HAN Mingming, YANG Chengwei, HUANG Xiang, LI Juan. A comparative study on the effect of different anesthesia methods on early postoperative inflammatory indicators and rehabilitation in patients undergoing cesarean section[J]. Chinese Journal of General Practice, 2024, 22(1): 34-38. doi: 10.16766/j.cnki.issn.1674-4152.003325
shu

A comparative study on the effect of different anesthesia methods on early postoperative inflammatory indicators and rehabilitation in patients undergoing cesarean section

doi: 10.16766/j.cnki.issn.1674-4152.003325

  • Department of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (Anhui Provincial Hospital), Hefei, Anhui 230001, China

Funds:

 2108085MH323

  • Received Date: 2023-08-03
    Available Online: 2024-03-09
    Abstract
  •   Objective  To evaluate the effects of different anaesthetic methods on inflammatory markers and rehabilitation after caesarean section, and provide a reference for the selection of anaesthetic methods for caesarean section surgery.  Methods  A total of 1 759 patients undergoing emergency caesarean section in the Southern District of the First Affiliated Hospital of the University of Science and Technology of China from January 2022 to May 2023 were divided into general anaesthesia group (group G, n=200) and epidural anaesthesia group (group E, n=1 559). The parturients were selected according to specific inclusion and exclusion criteria, and then the parturients in the two groups were matched in a 1∶1 ratio using the propensity score method. The effects of two different anaesthetic methods on white blood cell (WBC), platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) and postoperative rehabilitation were compared.  Results  WBC, NLR and MLR in group E were significantly higher than those before surgery, while WBC, PLR, NLR and MLR in group G were significantly higher than those before surgery. Compared with group E, the difference of PLR before and after surgery in group G [16.78 (0.16, 29.36) vs.-2.20 (-21.69, 15.17)] was significantly higher (P < 0.05). In group G, the time from induction of anaesthesia to fetal delivery [6 (3, 12) min vs. 43 (32, 54) min] and the time from skin incision to fetal delivery [3 (2, 7) min vs. 7 (6, 12) min] were significantly shortened, whereas the postoperative farting time [44 (39, 46) h vs. 39 (36, 43) h] was significantly longer (P < 0.05). At 5 minutes before skin incision and during skin incision, group E had significantly lower MAP and HR compared to group G (P < 0.05). There were no significant differences in intraoperative blood loss and postoperative hospital stay between the two groups (P>0.05).  Conclusion  Epidural anaesthesia may be more beneficial for the mother' s recovery, while general anaesthesia is appropriate for emergency delivery of the fetus.

     

    • FullText(HTML)
  • loading
    • References(19)
  • [1]
    ZHANG H, GUO K, SUN X, et al. Impact of anesthesia methods on perioperative systemic inflammation and long-term outcomes in patients undergoing surgery for hepatocellular carcinoma: a propensity score-matched analysis[J]. Ann Transl Med, 2021, 9(1): 49. doi: 10.21037/atm-20-3704
    [2]
    AUSTIN P C, STUART E A. The effect of a constraint on the maximum number of controls matched to each treated subject on the performance of full matching on the propensity score when estimating risk differences[J]. Stat Med, 2021, 40(1): 101-118. doi: 10.1002/sim.8764
    [3]
    WESSELS E, PERRIE H, SCRIBANTE J, et al. Quality of recovery in the perioperative setting: a narrative review[J]. J Clin Anesth, 2022, 78(110685). DOI: 10.1016/j.jclinane.2022.110685.
    [4]
    MUREŞAN A V, RUSSU E, ARBǍNAŞI E M, et al. The predictive value of NLR, MLR, and PLR in the outcome of end-stage kidney disease patients[J]. Biomedicines, 2022, 10(6): 1272. DOI: 10.3390/biomedicines10061272.
    [5]
    ZHENG M. Systemic inflammation shapes clinical outcomes in response to immune checkpoint blockade treatment: moving toward optimizing antitumor immunity[J]. J Immunother Cancer, 2023, 11(3): e006462. DOI: 10.1136/jitc-2022-006462.
    [6]
    HE L, WANG J, WANG F, et al. Increased neutrophil-to-lymphocyte ratio predicts the development of post-stroke infections in patients with acute ischemic stroke[J]. BMC neurology, 2020, 20(1): 328. doi: 10.1186/s12883-020-01914-x
    [7]
    FEST J, RUITER R, IKRAM M A, et al. Reference values for white blood-cell-based inflammatory markers in the Rotterdam Study: a population-based prospective cohort study[J]. Sci Rep, 2018, 8(1): 10566. DOI: 10.1038/s41598-018-28646-w.
    [8]
    WU J, ZHANG L, SHI J, et al. Macrophage phenotypic switch orchestrates the inflammation and repair/regeneration following acute pancreatitis injury[J]. EBioMedicine, 2020, 58(102920). DOI: 10.1016/j.ebiom.2020.102920.
    [9]
    NORRIS P C, LIBREROS S, SERHAN C N. Resolution metabolomes activated by hypoxic environment[J]. Sci Adv, 2019, 5(10): eaax4895. DOI: 10.1126/sciadv.aax4895.
    [10]
    SPILJAR M, STEINBACH K, RIGO D, et al. Cold exposure protects from neuroinflammation through immunologic reprogramming[J]. Cell Metab, 2021, 33(11): 2231-2246. e8. DOI: 10.1016/j.cmet.2021.10.002.
    [11]
    CRUM R J, HALL K, MOLINA C P, et al. Immunomodulatory matrix-bound nanovesicles mitigate acute and chronic pristane-induced rheumatoid arthritis[J]. NPJ Regen Med, 2022, 7(1): 13. DOI: 10.1038/s41536-022-00208-9.
    [12]
    BARRETT T J, BILALOGLU S, CORNWELL M, et al. Platelets contribute to disease severity in COVID-19[J]. J Thromb Haemost, 2021, 19(12): 3139-3153. doi: 10.1111/jth.15534
    [13]
    ROLFES V, RIBEIRO L S, HAWWARI I, et al. Platelets fuel the inflammasome activation of innate immune cells[J]. Cell Rep, 2020, 31(6): 107615. DOI: 10.1016/j.celrep.2020.107615.
    [14]
    DE ALMEIDA L G N, YOUNG D, CHOW L, et al. Proteomics and metabolomics profiling of platelets and plasma mediators of thrombo-inflammation in gestational hypertension and preeclampsia[J]. Cells, 2022, 11(8): 1256. DOI: 10.3390/cells11081256.
    [15]
    LUO X, LI D. Effects of epidural block anesthesia combined with general anesthesia on inflammatory factors, cognitive function and postoperative pain in patients with lung cancer after thoracoscopic surgery[J]. Am J Transl Res, 2021, 13(11): 13024-13033.
    [16]
    李艾伦, 仓静. 局麻药在术后慢性疼痛预防及治疗中的作用[J]. 中华全科医学, 2020, 18(5): 830-834. doi: 10.16766/j.cnki.issn.1674-4152.001368

    LI A L, CANG J. Effect of local anesthetics on the prevention and treatment of chronic post-surgical pain[J]. Chinese Journal of General Practice, 2020, 18(5): 830-834. doi: 10.16766/j.cnki.issn.1674-4152.001368
    [17]
    SALICATH J H, YEOH E C, BENNETT M H. Epidural analgesia versus patient-controlled intravenous analgesia for pain following intra-abdominal surgery in adults[J]. Cochrane Database Syst Rev, 2018, 8(8): CD010434. DOI: 10.1002/14651858.CD010434.pub2.
    [18]
    EROL M K, ŞENGEL A, TAMMO Ö, et al. The effect of TAP block use in postoperative analgesic in cesarean section[J]. Eur Rev Med Pharmacol Sci, 2023, 27(7): 2786-2793.
    [19]
    SINGH P M, SINGH N P, RESCHKE M, et al. Vasopressor drugs for the prevention and treatment of hypotension during neuraxial anaesthesia for caesarean delivery: a Bayesian network meta-analysis of fetal and maternal outcomes[J]. Br J Anaesth, 2020, 124(3): e95-e107. doi: 10.1016/j.bja.2019.09.045
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(6)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (194) PDF downloads(19) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return