Volume 22 Issue 1
Jan.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(1): 82-85
ZHONG Shuangfei, SHEN Na, HUANG Manxian. Correlation between serum vitamins and vascular endothelial growth factor in late pregnancy and pre-eclampsia and fetal growth restriction[J]. Chinese Journal of General Practice, 2024, 22(1): 82-85. doi: 10.16766/j.cnki.issn.1674-4152.003336
Citation: ZHONG Shuangfei, SHEN Na, HUANG Manxian. Correlation between serum vitamins and vascular endothelial growth factor in late pregnancy and pre-eclampsia and fetal growth restriction[J]. Chinese Journal of General Practice, 2024, 22(1): 82-85. doi: 10.16766/j.cnki.issn.1674-4152.003336
shu

Correlation between serum vitamins and vascular endothelial growth factor in late pregnancy and pre-eclampsia and fetal growth restriction

doi: 10.16766/j.cnki.issn.1674-4152.003336
  • 1.

    Department of Women's Health, Zhoushan Maternal and Child Health Hospital, Zhoushan, Zhejiang 316000, China

Funds:

 2021KY383

  • Received Date: 2023-03-30
    Available Online: 2024-03-09
    Abstract
  •   Objective  To investigate the association between serum vitamin D and vascular endothelial growth factor (VEGF) levels in late pregnancy and pre-eclampsia and fetal growth restriction (FGR), to provide a basis for clinical diagnosis and management of pre-eclampsia and FGR.  Methods  The 124 patients with pre-eclampsia in the third trimester of pregnancy from July 2020 to December 2022 at Zhoushan Maternal and Child Health Hospital were selected as the study group, including 38 patients with FGR. In addition, 54 normal pregnant women in their third trimester of pregnancy from the same term as the control group. Serum 25-hydroxyvitamin D (25-OH-D) levels were measured by electrochemical immunoassay, and the serum VEGF levels were measured by enzyme-linked immunosorbent assay.  Results  Serum 25-OH-D [(73.42±6.71) nmol/L] and VEGF [(412.31±35.24) pg/mL] in the study group were lower than in the control group [(94.78±5.25) nmol/L, (536.21±26.23) pg/mL, P < 0.05]. Serum 25-OH-D [(69.20±5.96) nmol/L] and VEGF [(394.70±32.17) pg/mL] were lower in the FGR group than in the non-FGR group [(82.97±7.28) nmol/L, (452.17±27.49) pg/mL, P < 0.05]. Pearson analysis showed that 25-OH-D and VEGF were negatively correlated with pre-eclampsia and FGR (P < 0.05). In predicting pre-eclampsia and FGR, the sensitivity of 25-OH-D were 83.30% and 76.29%, and the specificity were 77.43% and 64.19%; VEGF had a sensitivity of 80.13% and 68.08%, and a specificity of 68.92% and 56.24%. 25-OH-D and VEGF were independent risk factors for pre-eclampsia and FGR.  Conclusion  The decrease in serum 25-OH-D and VEGF levels in patients with pre-eclampsia and FGR in the third trimester of pregnancy is negatively correlated with the occurrence of pre-eclampsia and FGR and is a risk factor for pre-eclampsia and FGR.

     

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