Volume 22 Issue 1
Jan.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(1): 126-129
ZHOU Minhua, JI Xingzu, CHEN Lingyong. Clinical study of Xiaoyong Qufu Shengji Decoction combined with thymosin α1 in the treatment of bronchodilation in stable stage of lung Qi deficiency type[J]. Chinese Journal of General Practice, 2024, 22(1): 126-129. doi: 10.16766/j.cnki.issn.1674-4152.003347
Citation: ZHOU Minhua, JI Xingzu, CHEN Lingyong. Clinical study of Xiaoyong Qufu Shengji Decoction combined with thymosin α1 in the treatment of bronchodilation in stable stage of lung Qi deficiency type[J]. Chinese Journal of General Practice, 2024, 22(1): 126-129. doi: 10.16766/j.cnki.issn.1674-4152.003347
shu

Clinical study of Xiaoyong Qufu Shengji Decoction combined with thymosin α1 in the treatment of bronchodilation in stable stage of lung Qi deficiency type

doi: 10.16766/j.cnki.issn.1674-4152.003347

  • Department of Respiratory and Critical Care Medicine, Lishui Traditional Chinese Medicine Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine, Lishui, Zhejiang 323000, China

Funds:

 2023ZR058

  • Received Date: 2023-09-18
    Available Online: 2024-03-09
    Abstract
  •   Objective  Based on the traditional Chinese medicine (TCM) theory of "treating the lung close to the temperature", the effect of Xiaoyong Qufu Shengji Decoction combined with thymosin α1 on the stable stage of bronchiectasis was discussed to provide evidence of clinical curative effect.  Methods  From January 2021 to January 2023, 88 patients with lung Qi deficiency type bronchodilation admitted to Lishui Hospital of Traditional Chinese Medicine Affiliated to Zhejiang University of Chinese Medicine were selected and divided into control and study groups of 44 cases each by random number table method. On the basis of conventional symptomatic treatment, the control group was treated with thymosin α1, and the study group was treated with Xiaoyong Qufu Shengji Decoction combined with thymosin α1, all of which were continuously treated and observed for 8 weeks. The TCM syndrome score, lung function [percentage of forced expiratory volume in one second to expected value (FEV1 % pred), ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC)], T lymphocyte subsets [CD4+, CD8+, CD4+/CD8+] of the two groups were observed, and the efficacy and adverse reactions of the TCM syndrome were compared.  Results  After treatment, the scores for "cough" and "expectoration" and the total score for TCM syndrome were lower in the study group than in the control group (P < 0.05), and the total efficacy rate for TCM syndrome [90.91% (40/44)] was higher than that in the control group [72.73% (32/44), P < 0.05]. After treatment, FEV1 % pred, FEV1/FVC, CD4+, CD4+/CD8+ in the study group were higher than those in the control group (P < 0.05) and CD8+ were lower than those in the control group (P < 0.05). There was no significant difference in the rate of side effects between groups (P>0.05).  Conclusion  Xiaoyong Qufu Shengji Decoction combined with thymosin α1 can completely relieve the clinical symptoms of bronchodilation of lung Qi deficiency type, improve lung function and immune function, and enhance clinical efficacy and safety.

     

    • FullText(HTML)
  • loading
    • References(18)
  • [1]
    王玲, 师一涵, 杨恒, 等. 支气管扩张症年度进展2021[J]. 中华结核和呼吸杂志, 2022, 45(6): 592-597. doi: 10.3760/cma.j.cn112147-20220111-00036

    WANG L, SHI Y H, YANG H, et al. Annual review of bronchiectasis in 2021[J]. Chinese Journal of Tuberculosis and Respiratory Diseases, 2022, 45(6): 592-597. doi: 10.3760/cma.j.cn112147-20220111-00036
    [2]
    柯诗文, 岳学普, 朱伟, 等. 从肺间充质干细胞线粒体角度浅析全程温法治疗肺间质纤维化[J]. 中华中医药杂志, 2020, 35(5): 2491-2494. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202005061.htm

    KE S W, YUE X P, ZHU W. Treatment of pulmonary fibrosis by whole course warming from the perspective of mitochondria of pulmonary mesenchymal stem cells[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2020, 35(5): 2491-2494. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202005061.htm
    [3]
    支气管扩张症专家共识撰写协作组, 中华医学会呼吸病学分会感染学组. 中国成人支气管扩张症诊断与治疗专家共识[J]. 中华结核和呼吸杂志, 2021, 44(4): 311-321. doi: 10.3760/cma.j.cn112147-20200617-00717

    Expert Consensus writing collaborative group on bronchiectasis, Infection Group, Respiratory Society, Chinese Medical Association. Expert consensus on the diagnosis and treatment of adult bronchiectasis in China[J]. Chinese Journal of Tuberculosis and Respiratory Diseases, 2021, 44(4): 311-321. doi: 10.3760/cma.j.cn112147-20200617-00717
    [4]
    中华中医药学会内科分会, 中国民族医药学会肺病分会, 中华中医药学会肺系病分会. 支气管扩张症中医证候诊断标准(2019版)[J]. 中医杂志, 2020, 61(15): 1377-1380. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ202015024.htm

    Chinese Society of Traditional Chinese Medicine Internal Medicine Branch, Chinese Society of Ethnic Medicine Lung Disease Branch, Chinese Society of Traditional Chinese Medicine Lung Disease Branch. Diagnostic Criteria of Bronchiectasis for Trditional Chinese Medicine Syndromes (2019 edition)[J]. Journal of Traditional Chinese Medicine, 2020, 61(15): 1377-1380. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ202015024.htm
    [5]
    郑筱萸. 中药新药临床研究指导原则: 试行[M]. 北京: 中国医药科技出版社, 2002: 394-396.

    ZHENG X Y. Guiding Principles of clinical research on new Chinese medicine: Trial[M]. Beijing: China Medical Science and Technology Press, 2002: 394-396.
    [6]
    O'DONNELL A E. Bronchiectasis: a clinical review[J]. N Engl J Med, 2022, 387(6): 533-545. doi: 10.1056/NEJMra2202819
    [7]
    舒郁平, 余丹琪, 荣越, 等. 基于孟德尔随机化法的溃疡性结肠炎与支气管扩张症的因果关系研究[J]. 中华全科医学, 2023, 21(6): 924-926, 1043. doi: 10.16766/j.cnki.issn.1674-4152.003016

    SHU Y P, YU D Q, RONG Y, et al. Study on the causal relationship between ulcerative colitis and bronchiectasis based on Mendelian randomization[J]. Chinese Journal of General Practice, 2023, 21(6): 924-926, 1043. doi: 10.16766/j.cnki.issn.1674-4152.003016
    [8]
    吴宇, 武维屏. 武维屏诊治支气管扩张症临证思路[J]. 北京中医药, 2021, 40(6): 595-597. https://www.cnki.com.cn/Article/CJFDTOTAL-BJZO202106009.htm

    WU Y, WU W P (guidance). Clinical thinking of Wu Weiping's diagnosis and treatment of bronchiectasis[J]. Beijing Journal of Traditional Chinese Medicine, 2021, 40(6): 595-597. https://www.cnki.com.cn/Article/CJFDTOTAL-BJZO202106009.htm
    [9]
    陈金丽, 梁爱武, 黎云, 等. 支气管扩张症肺脾同调的治疗思路探讨[J]. 广西医学, 2022, 44(16): 1925-1927. https://www.cnki.com.cn/Article/CJFDTOTAL-GYYX202216023.htm

    CHEN JINLI, LIANG AIWU, LI YUN, et al. Exploration of therapeutic thoughts for concurrently regulating lung and spleen in bronchiectasis[J]. Guangxi Medical Journal, 2022, 44(16): 1925-1927. https://www.cnki.com.cn/Article/CJFDTOTAL-GYYX202216023.htm
    [10]
    何欣桥, 喻清和. 喻清和治疗支气管扩张症经验[J]. 广州中医药大学学报, 2022, 39(8): 1916-1920. https://www.cnki.com.cn/Article/CJFDTOTAL-REST202208033.htm

    HE X Q. YU Q H. YU Qing-He's Experience in Treating Bronchiectasis[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2022, 39(8): 1916-1920. https://www.cnki.com.cn/Article/CJFDTOTAL-REST202208033.htm
    [11]
    莫丽莎, 朱伟, 兰智慧, 等. 国医大师洪广祥治疗支气管扩张症经验探析[J]. 中华中医药杂志, 2020, 35(12): 6105-6107. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202012050.htm

    MO L S, ZHU W, LAN Z H, et al. Analysis on TCM master HONG Guang-xiang's experience in the treatment of bronchiectasis[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2020, 35(12): 6105-6107. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202012050.htm
    [12]
    赵媛, 丛晓东, 宗慧琪, 等. 支气管扩张症的治疗难点及中西医治疗策略[J]. 世界中医药, 2023, 18(5): 699-703. doi: 10.3969/j.issn.1673-7202.2023.05.020

    ZHAO Y, CONG X D, ZONG H Q, et al. Difficulties and Strategies of Traditional Chinese and Western Medicine in the Treatment of Bronchiectasis[J]. World Chinese Medicine, 2023, 18(5): 699-703. doi: 10.3969/j.issn.1673-7202.2023.05.020
    [13]
    陈磊, 黄燕, 杨爽. 从肺脾论治支气管扩张症的研究进展[J]. 内蒙古中医药, 2020, 39(1): 157-158. https://www.cnki.com.cn/Article/CJFDTOTAL-NZYY202001091.htm

    CHEN L, HUANG Y, YANG S. Research progress of treating bronchiectasis from lung and spleen[J]. Nei Mongol Journal of Traditional Chinese Medicine, 2020, 39(1): 157-158. https://www.cnki.com.cn/Article/CJFDTOTAL-NZYY202001091.htm
    [14]
    吴梦菁, 黄东晖. 从瘀论治支气管扩张稳定期[J]. 山东中医药大学学报, 2021, 45(5): 585-589. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYX202105004.htm

    WU M J, HUANG D H. Treatment of stable bronchiectasis based on blood stasis[J]. Journal of Shandong University of Traditional Chinese Medicine, 2021, 45(5): 585-589. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYX202105004.htm
    [15]
    艾健, 王淑英, 姬晓辉, 等. 基于网络药理学探讨健脾祛湿化瘀膏对支气管扩张缓解期的作用机制[J]. 浙江中医药大学学报, 2020, 44(11): 1102-1112. https://www.cnki.com.cn/Article/CJFDTOTAL-BHON202011016.htm

    AI J, WANG S Y, JI X H, et al. Mechanism of Jianpi Qushi Huayu Ointment on the Relief Period of Bronchiectasis Based on Network Pharmacology[J]. Journal of Zhejiang Chinese Medical University, 2020, 44(11): 1102-1112. https://www.cnki.com.cn/Article/CJFDTOTAL-BHON202011016.htm
    [16]
    李霞, 刘洁净, 秦鸿. 健脾益肺汤对支气管扩张症(稳定期)的临床疗效及对血清炎症水平的影响[J]. 辽宁中医杂志, 2022, 49(5): 127-130. https://www.cnki.com.cn/Article/CJFDTOTAL-LNZY202205036.htm

    LI X, LIU J J, QIN H. Clinical Effect of Jianpi Yifei Decoction on Bronchiectasis(Stable Stage)and Its Influence on Serum Inflammatory[J]. Liaoning Journal of Traditional Chinese Medicine, 2022, 49(5): 127-130. https://www.cnki.com.cn/Article/CJFDTOTAL-LNZY202205036.htm
    [17]
    TAK A S, SATAPATHY J, JANA M, et al. Monogenic lupus with homozygous C4A deficiency presenting as bronchiectasis and immune-mediated thrombocytopenia[J]. Rheumatol Intl, 2022, 42(8): 1477-1482. doi: 10.1007/s00296-021-04943-y
    [18]
    王聪聪, 高永华, 张国俊. 原发性免疫缺陷病相关支气管扩张症患者的临床特征分析[J]. 检验医学与临床, 2022, 19(23): 3268-3270. doi: 10.3969/j.issn.1672-9455.2022.23.027

    WANG C C, GAO Y H, ZHANG G J. Clinical characteristics of patients with primary immunodeficiency disease associated bronchiectasis[J]. Laboratory Medicine and Clinic, 2022, 19(23): 3268-3270. doi: 10.3969/j.issn.1672-9455.2022.23.027
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (72) PDF downloads(3) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return