Volume 22 Issue 1
Jan.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(1): 172-174
ZHONG Haimei, LING Huaxiang, HUANG Lixia, WANG Hongyan. Adult common variable immunodeficiency: a case report and literature review[J]. Chinese Journal of General Practice, 2024, 22(1): 172-174. doi: 10.16766/j.cnki.issn.1674-4152.003357
Citation: ZHONG Haimei, LING Huaxiang, HUANG Lixia, WANG Hongyan. Adult common variable immunodeficiency: a case report and literature review[J]. Chinese Journal of General Practice, 2024, 22(1): 172-174. doi: 10.16766/j.cnki.issn.1674-4152.003357
shu

Adult common variable immunodeficiency: a case report and literature review

doi: 10.16766/j.cnki.issn.1674-4152.003357
  • 1.

    Department of General Practice, Union Shenzhen Hospital of Huazhong University of Science and Technology, Shenzhen, Guangdong 518052, China

Funds:

 A2022497

  • Received Date: 2023-05-11
    Available Online: 2024-03-09
    Abstract
  • This paper reports a case of adult common variable immunodeficiency (CVID). The patient was a 38-year old man who had been in good health prior to the onset of the disease and had been hospitalized several times over the previous 10 years for pulmonary and other infections. This time, the patient was hospitalized again for a lung infection and was found to have low immunoglobulin levels. After excluding other possible causes of low immunoglobulin, the patient was diagnosed with CVID. The symptoms improved after intravenous immunoglobulin, anti-infective and other treatments. However, there was no significant improvement in immunoglobulin. It is suggested that the patient should be regularly supplemented with intravenous immunoglobulin for a long time after discharge. The relevant literature was also reviewed in this paper.

     

    • FullText(HTML)
  • loading
    • References(22)
  • [1]
    GRZEŚ K E, DABROWSKA A, URBAÑCZYK A, et al. Common variable immunodeficiency: different faces of the same disease[J]. Postepy Dermatol Alergol, 2021, 38(5): 873-880. doi: 10.5114/ada.2021.110067
    [2]
    中华医学会呼吸病学分会. 支气管肺泡灌洗液细胞学检测技术规范(草案)[J]. 中华结核和呼吸杂志, 2002, 25(7): 390-391. https://www.cnki.com.cn/Article/CJFDTOTAL-NBYX200304039.htm

    Chinese Thoracic Society. Technical Specification for cytological test of bronchoalveolar lavage Fluid (Draft)[J]. Chinese Journal of Tuberculosis and Respiratory Diseases, 2002, 25(7): 390-391. https://www.cnki.com.cn/Article/CJFDTOTAL-NBYX200304039.htm
    [3]
    CUNNINGHAM-RUNDLES C. Common variable immune deficiency: dissection of the variable[J]. Immunol Rev, 2019, 287(1): 145-161. doi: 10.1111/imr.12728
    [4]
    RESNICK E S, MOSHIER E L, GODBOLD J H, et al. Morbidity and mortality in common variable immune deficiency over 4 decades[J]. Blood, 2012, 119(7): 1650-1657. doi: 10.1182/blood-2011-09-377945
    [5]
    蔡萧鹏, 邱志峰, 谢静, 等. 普通变异型免疫缺陷病的临床特征及淋巴细胞亚群变化[J]. 中国临床医生, 2018, 46(6): 648-650. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLYS201806009.htm

    CAI X P, QIU Z F, XIE J, et al. Clinical features and lymphocyte subset changes in common variant immunodeficiency disease[J]. Chinese Journal for Clinicians, 2018, 46(6): 648-650. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLYS201806009.htm
    [6]
    MAGLIONE P, GEREIGE J, LEE T. Consideration of pulmonary hypertension in the evaluation of common variable immunodeficiency[J]. Ann Allergy Asthma Immunol, 2021, 127(4): 513. doi: 10.1016/j.anai.2021.07.024
    [7]
    J∅RGENSEN S, TR∅SEID M, KUMMEN M, et al. Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation[J]. Mucosal Immunol, 2016, 9(6): 1455-1465. doi: 10.1038/mi.2016.18
    [8]
    SOMPORNRATTANAPHAN M, TONGDEE R, WONGSA C, et al. Fatal liver mass rupture in a common-variable-immunodeficiency patient with probable nodular regenerating hyperplasia[J]. Allergy Asthma Clin, Immunol, 2022, 18(1): 2. doi: 10.1186/s13223-021-00643-1
    [9]
    ZAREZADEH MEHRABADI A, AGHAMOHAMADI N, ABOLHASSANI H, et al. Comprehensive assessment of skin disorders in patients with common variable immunodeficiency (CVID)[J]. J Clin Immunol, 2022, 42: 653-664. doi: 10.1007/s10875-022-01211-x
    [10]
    TINAZZI E, OSTI N, BERI R, et al. Pathogenesis of immune thrombocytopenia in common variable immunodeficiency[J]. Autoimmun Rev, 2020, 19(9): 102616. DOI: 10.1016/j.autrev.2020.102616.
    [11]
    AMERATUNGA R, ALLAN C, WOON S T. Defining common variable immunodeficiency disorders in 2020[J]. Immunol Allergy Clin North Am, 2020, 40(3): 403-420. doi: 10.1016/j.iac.2020.03.001
    [12]
    YAZDANI R, HABIBI S, SHARIFI L, et al. Common variable immunodeficiency: epidemiology, pathogenesis, clinical manifestations, diagnosis, classification, and management[J]. J Investig Allergol Clin Immunol, 2020, 30(1): 14-34. doi: 10.18176/jiaci.0388
    [13]
    KLOCPERK A, FRIEDMANN D, SCHLAAK A E, et al. Distinct CD8 T cell populations with differential exhaustion profiles associate with secondary complications in common variable immunodeficiency[J]. J Clin Immunol, 2022, 42(6): 1254-1269. doi: 10.1007/s10875-022-01291-9
    [14]
    WEHR C. Trying to understand NK cell Function in vivo points towards a severity score for CVID patients[J]. E Bio Medicine, 2016, 6: 18-19.
    [15]
    DIAZ-ALBEROLA I, ESPUCH-OLIVER A, GARCIA-AZNAR J M, et al. Common variable immunodeficiency associated with a De Novo IKZF1 variant and a low humoral immune response to the SARS-CoV-2 vaccine[J]. J Clin Med, 2022, 11(9): 2303. doi: 10.3390/jcm11092303
    [16]
    BOGAERT D J, DULLAERS M, LAMBRECHT B N, et al. Genes associated with common variable immunodeficiency: one diagnosis to rule them all?[J]. J Med Genet, 2016, 53(9): 575-590. doi: 10.1136/jmedgenet-2015-103690
    [17]
    MILARDI G, DI LORENZO B, GEROSA J, et al. Follicular helper T cell signature of replicative exhaustion, apoptosis, and senescence in common variable immunodeficiency[J]. Eur J Immunol, 2022, 52(7): 1171-1189. doi: 10.1002/eji.202149480
    [18]
    QUINTI I, SORESINA A, SPADARO G, et al. Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency[J]. J Clin Immunol, 2007, 27(3): 308-316. doi: 10.1007/s10875-007-9075-1
    [19]
    SIMÓN-FUENTES M, SÁNCHEZ-RAMÓN S, FERNÁNDEZ-PAREDES L, et al. Intravenous immunoglobulins promote an expansion of monocytic myeloid-derived suppressor cells (MDSC) in CVID patients[J]. J Clin Immunol, 2022, 42(5): 1093-1105. doi: 10.1007/s10875-022-01277-7
    [20]
    马旭灿, 丁颖威, 章炳文. 丙种球蛋白冲击治疗重症社区获得性肺炎的疗效及对患者血清免疫蛋白和淋巴细胞亚群的影响[J]. 中华全科医学, 2021, 19(9): 1497-1583. doi: 10.16766/j.cnki.issn.1674-4152.002095

    MA X C, DING Y W, ZHANG B W. Effect of gamma globulin pulse therapy on patients with severe community-acquired pneumonia and on serum immune proteins and lymphocyte subsets[J]. Chinese Journal of General Practice, 2021, 19(9): 1497-1583. doi: 10.16766/j.cnki.issn.1674-4152.002095
    [21]
    BAUMANN U, ROUTES J, SOLER-PALACÍN P, et al. The lung in primary immunodeficiencies: new concepts in infection and inflammation[J]. Front Immunol, 2018, 9: 1837.
    [22]
    VAN LEEUWEN L, GEURTSVANKESSEL C, ELLERBROEK P, et al. Immunogenicity of the mRNA-1273 COVID-19 vaccine in adult patients with inborn errors of immunity[J]. J Allergy Clin Immunol, 2022, 149(6): 1949-1957. doi: 10.1016/j.jaci.2022.04.002
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (77) PDF downloads(15) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return