Volume 22 Issue 2
Feb.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(2): 187-190
CAI Han, ZHANG Jun, XU Hui, LI Shixia, WANG Xiaoquan. Exploring the correlation between serum vitamin D levels, cognitive function, and depressive mood in elderly individuals with MCI[J]. Chinese Journal of General Practice, 2024, 22(2): 187-190. doi: 10.16766/j.cnki.issn.1674-4152.003361
Citation: CAI Han, ZHANG Jun, XU Hui, LI Shixia, WANG Xiaoquan. Exploring the correlation between serum vitamin D levels, cognitive function, and depressive mood in elderly individuals with MCI[J]. Chinese Journal of General Practice, 2024, 22(2): 187-190. doi: 10.16766/j.cnki.issn.1674-4152.003361
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Exploring the correlation between serum vitamin D levels, cognitive function, and depressive mood in elderly individuals with MCI

doi: 10.16766/j.cnki.issn.1674-4152.003361
  • 1.

    Department of Psychiatry, the Fourth People' s Hospital of Wuhu, Wuhu, Anhui 241002, China

Funds:

 2023AH040381

 2022cg31

  • Received Date: 2023-11-20
    Available Online: 2024-03-27
    Abstract
  •   Objective  The objective of this study is to investigate the correlation among serum vitamin D levels, cognitive function, and depressive mood in elderly individuals with mild cognitive impairment (MCI), aiming to establish a theoretical foundation for clinical intervention.  Methods  Between February 2023 and August 2023, a total of 315 subjects with MCI were screened from the elderly community population. Blood samples were collected to measure vitamin D levels, with 155 subjects categorized as vitamin D deficient group and 160 subjects categorized as normal group. A comparative analysis was conducted to assess the general conditions of these two groups. Additionally, scores from the mini-mental state examination (MMSE), the Montreal cognitive assessment (MoCA), the geriatric depression scale (GDS), and centre for epidemiological studies depression scale (CES-D) were compared between the two groups.  Results  Compared with the normal group, the vitamin D deficient group exhibited significantly lower scores in immediate memory (9.01±1.41 vs. 8.46±2.36), calculation (3.64±1.60 vs. 3.20±1.76), memory [2.00 (1.00, 3.00) vs. 2.00 (1.00, 2.00)], repeat [1.00 (0.00, 1.00) vs. 1.00 (0.00, 1.00)], and three-step command (2.59±0.71 vs. 2.28±0.90) of MMSE. The total score (25.10±3.05 vs. 23.56±3.90), and language score of MoCA, as well as memory and total score, were also significantly lower in the vitamin D deficient group (P<0.05). Furthermore, the total score of CES-D in the vitamin D deficient group (13.10±4.12 vs. 11.26±4.81) was significantly higher (P<0.01). Correlation analysis revealed a positive association between vitamin D levels and overall cognitive function (P<0.05), while serum vitamin D levels showed a negative correlation with depressive mood (P<0.05).  Conclusion  Vitamin D level has been found to be associated with cognition and depression in individuals with MCI.

     

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