Volume 22 Issue 2
Feb.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(2): 187-190
CAI Han, ZHANG Jun, XU Hui, LI Shixia, WANG Xiaoquan. Exploring the correlation between serum vitamin D levels, cognitive function, and depressive mood in elderly individuals with MCI[J]. Chinese Journal of General Practice, 2024, 22(2): 187-190. doi: 10.16766/j.cnki.issn.1674-4152.003361
Citation: CAI Han, ZHANG Jun, XU Hui, LI Shixia, WANG Xiaoquan. Exploring the correlation between serum vitamin D levels, cognitive function, and depressive mood in elderly individuals with MCI[J]. Chinese Journal of General Practice, 2024, 22(2): 187-190. doi: 10.16766/j.cnki.issn.1674-4152.003361
shu

Exploring the correlation between serum vitamin D levels, cognitive function, and depressive mood in elderly individuals with MCI

doi: 10.16766/j.cnki.issn.1674-4152.003361
  • 1.

    Department of Psychiatry, the Fourth People' s Hospital of Wuhu, Wuhu, Anhui 241002, China

Funds:

 2023AH040381

 2022cg31

  • Received Date: 2023-11-20
    Available Online: 2024-03-27
    Abstract
  •   Objective  The objective of this study is to investigate the correlation among serum vitamin D levels, cognitive function, and depressive mood in elderly individuals with mild cognitive impairment (MCI), aiming to establish a theoretical foundation for clinical intervention.  Methods  Between February 2023 and August 2023, a total of 315 subjects with MCI were screened from the elderly community population. Blood samples were collected to measure vitamin D levels, with 155 subjects categorized as vitamin D deficient group and 160 subjects categorized as normal group. A comparative analysis was conducted to assess the general conditions of these two groups. Additionally, scores from the mini-mental state examination (MMSE), the Montreal cognitive assessment (MoCA), the geriatric depression scale (GDS), and centre for epidemiological studies depression scale (CES-D) were compared between the two groups.  Results  Compared with the normal group, the vitamin D deficient group exhibited significantly lower scores in immediate memory (9.01±1.41 vs. 8.46±2.36), calculation (3.64±1.60 vs. 3.20±1.76), memory [2.00 (1.00, 3.00) vs. 2.00 (1.00, 2.00)], repeat [1.00 (0.00, 1.00) vs. 1.00 (0.00, 1.00)], and three-step command (2.59±0.71 vs. 2.28±0.90) of MMSE. The total score (25.10±3.05 vs. 23.56±3.90), and language score of MoCA, as well as memory and total score, were also significantly lower in the vitamin D deficient group (P<0.05). Furthermore, the total score of CES-D in the vitamin D deficient group (13.10±4.12 vs. 11.26±4.81) was significantly higher (P<0.01). Correlation analysis revealed a positive association between vitamin D levels and overall cognitive function (P<0.05), while serum vitamin D levels showed a negative correlation with depressive mood (P<0.05).  Conclusion  Vitamin D level has been found to be associated with cognition and depression in individuals with MCI.

     

    • FullText(HTML)
  • loading
    • References(23)
  • [1]
    潘建波, 谢渭根, 成灵英, 等. 阿尔茨海默病患者家庭照料者益处发现与虐待倾向的相关性分析[J]. 中华全科医学, 2023, 21(8): 1332-1334, 1401. doi: 10.16766/j.cnki.issn.1674-4152.003116

    PAN J B, XIE W G, CHENG L Y, et al. Correlation analysis between benefit finding and abuse tendency of family caregivers of patients with Alzheimer ' s disease[J]. Chinese Journal of General Practice, 2023, 21(8): 1332-1334, 1401. doi: 10.16766/j.cnki.issn.1674-4152.003116
    [2]
    张晓帆, 贾小芳, 张继国, 等. 中国15省份中老年人营养素相关膳食模式与轻度认知功能障碍的关联性分析[J]. 中华流行病学杂志, 2023, 44(3): 408-414.

    ZHANG X F, JIA X F, ZHANG J G, et al. Relationship between nutrient-related dietary pattern and mild cognitive impairment in middle-aged and elderly people in 15 provinces of China[J]. Chinese Journal of Epidemiology, 2023, 44(3): 408-414.
    [3]
    殷歌, 黎佳思, 范存秀, 等. 维生素D与认知功能[J]. 中华行为医学与脑科学杂志, 2021, 30(4): 367-372. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY202402004.htm

    YIN G, LI J S, FAN C X, et al. Vitamin D and cognitive function[J]. Chinese Journal of Behavioral Medicine and Brain Sciences, 2021, 30(4): 367-372. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY202402004.htm
    [4]
    CHENG L, DONG R R, SONG C M, et al. Mediation effects of IL-1β and IL-18 on the association between vitamin D levels and mild cognitive impairment among Chinese older adults: a case-control study in Taiyuan, China[J]. Front Aging Neurosci, 2022, 14: 836311. DOI: 10.3389/fnagi.2022.836311.
    [5]
    KULKARNI U D, KAMALKISHORE M K, VITTALRAO A M, et al. Cognition enhancing abilities of vitamin D, epalrestat and their combination in diabetic rats with and without scopolamine induced amnesia[J]. Cogn Neurodyn, 2022, 16(2): 483-495. doi: 10.1007/s11571-021-09718-6
    [6]
    赵晓玲, 辜蕊, 曹娜, 等. 血清25-羟基维生素D水平与帕金森病患者认知功能减退的相关性[J]. 脑与神经疾病杂志, 2023, 31(5): 295-298. https://www.cnki.com.cn/Article/CJFDTOTAL-LYSJ202305008.htm

    ZHAO X L, GU R, CAO N, et al. Correlation between serum 25-hydroxyvitamin D Ievel and cognitive decline in patients with Parkinson ' s disease[J]. Journal of Brain and Nervous Diseases, 2023, 31(5): 295-298. https://www.cnki.com.cn/Article/CJFDTOTAL-LYSJ202305008.htm
    [7]
    XU H, FIOCCO A J, LIU X H, et al. Association between tea consumption and cognitive function in cognitively healthy older adults and older adults with mild cognitive impairment[J]. Gen Psychiatr, 2021, 34(4): e100512. DOI: 10.1136/gpsych-2021-100512.
    [8]
    JANSE A, REST O, GROOT L, et al. The association of vitamin D status with mild cognitive impairment and dementia subtypes: a cross-sectional analysis in Dutch geriatric outpatients[J]. J Alzheimers Dis, 2023, 91(4): 1359-1369. doi: 10.3233/JAD-220732
    [9]
    KUMAR A, VERMA A, CHAURASIA R N. Vitamin D and inflammatory cytokines association in mild cognitive impaired subjects[J]. Neurosci Lett, 2023, 795: 137044. DOI: 10.1016/j.neulet.2022.137044.
    [10]
    冯莓婷, 刘佳昊, 王晓丽. 血清25-羟维生素D、同型半胱氨酸、尿酸水平与老年高血压患者发生轻度认知功能障碍的相关性[J]. 江苏大学学报(医学版), 2023, 33(3): 252-257, 264. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJYZ202303011.htm

    FENG M T, LIU J H, WANG X L. Relationship between serum 25-hydroxyvitamin D, homocysteine, uric acid and mild cognitive impairment in elderly patients with hypertension[J]. Journal of Jiangsu University: Medicine Edition, 2023, 33(3): 252-257, 264. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJYZ202303011.htm
    [11]
    SHIH E J, LEE W J, HSU J L, et al. Effect of vitamin D on cognitive function and white matter hyperintensity in patients with mild Alzheimer ' s disease[J]. Geriatr Gerontol Int, 2020, 20(1): 52-58. doi: 10.1111/ggi.13821
    [12]
    YE X S, ZHOU Q L, REN P C, et al. The synaptic and circuit functions of vitamin D in neurodevelopment disorders[J]. Neuropsychiatr Dis Treat, 2023, 19: 1515-1530. doi: 10.2147/NDT.S407731
    [13]
    孔祥增, 李艳敏, 孟莉, 等. 血清1, 25(OH)2D3水平与脑小血管病患者认知功能损害程度的相关性分析[J]. 脑与神经疾病杂志, 2023, 31(4): 199-204. https://www.cnki.com.cn/Article/CJFDTOTAL-LYSJ202304001.htm

    KONG X Z, LI Y M, MENG L, et al. Correlation analysis of serum 1, 25(OH)2D3level with cognitive impairment in patients with small cerebral vascular disease[J]. Journal of Brain and Nervous Diseases, 2023, 31(4): 199-204. https://www.cnki.com.cn/Article/CJFDTOTAL-LYSJ202304001.htm
    [14]
    ZAJAC I T, BARNES M, CAVUOTO P, et al. The effects of vitamin D-enriched mushrooms and vitamin D3 on cognitive performance and mood in healthy elderly adults: a randomised, double-blinded, placebo-controlled trial[J]. Nutrients, 2020, 12(12): 3847. DOI: 10.3390/nu12123847.
    [15]
    ASANTE E O, MAI X M, ELDHOLM R S, et al. Vitamin D status over time and cognitive function in norwegian older adults: a prospective cohort of the HUNT study[J]. J Nutr Health Aging, 2023, 27(1): 30-37. doi: 10.1007/s12603-022-1867-8
    [16]
    WINCZYK K, KOSTKA T, PISAREK H, et al. Hormones and depression in the advanced age[J]. Endokrynol Pol, 2022, 73(6): 917-921. doi: 10.5603/EP.a2022.0094
    [17]
    马春, 王佳琳, 杨鹏羽, 等. 中国老年轻度认知障碍病人抑郁情绪检出率及影响因素的系统评价[J]. 循证护理, 2023, 9(15): 2685-2691. https://www.cnki.com.cn/Article/CJFDTOTAL-XZHL202315004.htm

    MA C, WANG J L, YANG P Y, et al. The detection rate and influencing factors of depressive symptoms among the elderly with mild cognitive impairment in China: a systematic review[J]. Chinese Evidence-Based Nursing, 2023, 9(15): 2685-2691. https://www.cnki.com.cn/Article/CJFDTOTAL-XZHL202315004.htm
    [18]
    苏玉洁, 孙嫣, 凌怡, 等. 老年轻度认知损害患者抑郁情绪与认知功能相关性分析[J]. 中国现代神经疾病杂志, 2023, 23(4): 292-302. https://www.cnki.com.cn/Article/CJFDTOTAL-XDJB202304005.htm

    SU Y J, SUN Y, LING Y, et al. The relationship between depression and cognitive function in patients with mild cognitive impairment[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2023, 23(4): 292-302. https://www.cnki.com.cn/Article/CJFDTOTAL-XDJB202304005.htm
    [19]
    王锦秀, 王剑涛, 胡月, 等. 抑郁和焦虑与老年认知障碍患者认知水平的相关性分析[J]. 中国临床医学, 2022, 29(4): 536-543. https://www.cnki.com.cn/Article/CJFDTOTAL-LCYX202204003.htm

    WANG J X, WANG J T, HU Y, et al. Correlation of depression and anxiety and cognitive function in elderly patients with cognitive impairment[J]. Chinese Journal of Clinical Medicine, 2022, 29(4): 536-543. https://www.cnki.com.cn/Article/CJFDTOTAL-LCYX202204003.htm
    [20]
    ROY N M, Al-HARTHI L, SAMPAT N, et al. Impact of vitamin D on neurocognitive function in dementia, depression, schizophrenia and ADHD[J]. Front Biosci (Landmark Ed), 2021, 26(3): 566-611. doi: 10.2741/4908
    [21]
    SOMOZA-MONCADA M M, TURRUBIATES-HERNÁNDEZ F J, MUÑOZ-VALLE J F, et al. Vitamin D in depression: a potential bioactive agent to reduce suicide and suicide attempt risk[J]. Nutrients, 2023, 15(7): 1765. DOI: 10.3390/nu15071765.
    [22]
    RAHMAN S T, WATERHOUSE M, ROMERO B D, et al. Effect of vitamin D supplementation on depression in older Australian adults[J]. Int J Geriatr Psychiatry, 2023, 38(1): e5847. DOI: 10.1002/gps.5847.
    [23]
    MIKOLA T, MARX W, LANE M M, et al. The effect of vitamin D supplementation on depressive symptoms in adults: a systematic review and meta-analysis of randomized controlled trials[J]. Crit Rev Food Sci Nutr, 2023, 63(33): 11784-11801. doi: 10.1080/10408398.2022.2096560
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (68) PDF downloads(11) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return