Volume 22 Issue 2
Feb.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(2): 195-197
LIU Yuting, SHI Min, CHEN Yanna, YIN Lulu, HU Changjun. Serum levels of C1q/TNF-related protein 9 and its association with insulin resistance in gestational diabetes mellitus[J]. Chinese Journal of General Practice, 2024, 22(2): 195-197. doi: 10.16766/j.cnki.issn.1674-4152.003363
Citation: LIU Yuting, SHI Min, CHEN Yanna, YIN Lulu, HU Changjun. Serum levels of C1q/TNF-related protein 9 and its association with insulin resistance in gestational diabetes mellitus[J]. Chinese Journal of General Practice, 2024, 22(2): 195-197. doi: 10.16766/j.cnki.issn.1674-4152.003363
shu

Serum levels of C1q/TNF-related protein 9 and its association with insulin resistance in gestational diabetes mellitus

doi: 10.16766/j.cnki.issn.1674-4152.003363

  • Department of Endocrinology, the Affiliated Huaian No.1 People' s Hospital of Nanjing Medical University, Huai' an, Jiangsu 223300, China

Funds:

 81700723

  • Received Date: 2023-08-10
    Available Online: 2024-03-27
    Abstract
  •   Objective  To investigate the relationship between serum C1q/tumor necrosis factor-related protein 9 (CTRP9) and gestational diabetes mellitus (GDM) and its clinical significance.  Methods  A total of 35 patients with GDM and 37 pregnant women without the condition were enrolled. The general characteristics, glucose metabolism indicators, serum CTRP9 levels and other adipokine levels were compared between the two groups. In addition, a Pearson correlation analysis was conducted to examine the correlation between serum CTRP9, other cytokines and clinical indexes in pregnant women with GDM.  Results  The fasting plasma glucose (FPG), OGTT 1hPG, OGTT 2hPG, fasting insulin (FINS), HOMA-IR, interleukin-6 (IL-6), leptin, tumor necrosis factor-α (TNF-α), and CTRP9 in the GDM group were higher than those in the control group (P<0.05). The results of the Pearson correlation analysis indicated that serum CTRP9 was positively correlated with FPG, 1hPG, 2hPG, FINS, HOMA-IR, IL-6 and TNF-α (P<0.05). The logistic regression analysis showed that elevated HOMA-IR (OR=14.771, P=0.046) and CTRP9 (OR=4.965, P=0.002) were independent risk factors for GDM. ROC analysis demonstrated that CTRP9 and HOMA-IR had areas under the curve of 0.914 and 0.822, respectively, for diagnosing GDM. The combined detection had an area under the curve of 0.943, indicating optimal diagnostic efficiency.  Conclusion  The serum CTRP9 level is elevated in GDM. Elevated serum CTRP9 level is an independent risk factor for GDM. Furthermore, the combination of serum CTRP9 and HOMA-IR was more efficient in screening for GDM.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    中华医学会妇产科学分会产科学组, 中华医学会围产医学分会, 中国妇幼保健协会妊娠合并糖尿病专业委员会. 妊娠期高血糖诊治指南(2022)[第二部分][J]. 中华妇产科杂志, 2022, 57(2): 81-90. https://www.cnki.com.cn/Article/CJFDTOTAL-GWVC202206020.htm

    Chinese Society of Obstetrics and Gynecology, Chinese Society of Perinatal Medicine, Professional Committee of Gestational Diabetes Mellitus, Chinese Maternal and Child Health Association. Guideline of diagnosis and treatment of hyperglycemia in pregnancy(2022)[Part two][J]. Chinese Journal of Obstetrics and Gynecology, 2022, 57(2): 81-90. https://www.cnki.com.cn/Article/CJFDTOTAL-GWVC202206020.htm
    [2]
    NERI C, SERAFINO E, MORLANDO M, et al. Microbiome and gestational diabetes: interactions with pregnancy outcome and long-term infant health[J]. J Diabetes Res, 2021, 2021: 9994734. DOI: 10.1155/2021/9994734.
    [3]
    MOON J H, JANG H C. Gestational diabetes mellitus: diagnostic approaches and maternal-offspring complications[J]. Diabetes Metab J, 2022, 46(1): 3-14. doi: 10.4093/dmj.2021.0335
    [4]
    XU X, HUANG F P, GUO Y N, et al. Interactive effect of prepregnancy overweight/obesity and GDM history on prevalence of GDM in biparous women[J]. Front Endocrinol (Lausanne), 2023, 14: 1084288. DOI: 10.3389/fendo.2023.1084288.
    [5]
    ŠIMJÁK P, CINKAJZLOVÁ A, ANDERLOVÁ K, et al. The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus[J]. J Endocrinol, 2018, 238(2): R63-R77. doi: 10.1530/JOE-18-0032
    [6]
    XIA L, ZHANG H J, SHI Q, et al. Protective role of CTRP3 and CTRP9 in the development of gestational diabetes mellitus[J]. Clin Lab, 2020, 66(11). DOI: 10.7754/Clin.Lab.2020.200247.
    [7]
    NA N, JI M. Role of first-trimester serum C1q/TNF-related protein 9 in gestational diabetes mellitus[J]. Clin Lab, 2020, 66(12). DOI: 10.7754/Clin.Lab.2020.200434.
    [8]
    JUAN J, YANG H X. Prevalence, prevention, and lifestyle intervention of gestational diabetes mellitus in China[J]. Int J Environ Res Public Health, 2020, 17(24): 9517. DOI: 10.3390/ijerph17249517.
    [9]
    CHO N H, SHAW J E, KARURANGA S, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045[J]. Diabetes Res Clin Pract, 2018, 138: 271-281. doi: 10.1016/j.diabres.2018.02.023
    [10]
    林苗, 周平. 妊娠期糖尿病孕妇产后高血糖的危险因素分析[J]. 中华全科医学, 2022, 20(8): 1350-1352, 1356. doi: 10.16766/j.cnki.issn.1674-4152.002594

    LIN M, ZHOU P. Risk factors of postpartum hyperglycaemia in pregnant women with gestational diabetes mellitus[J]. Chinese Journal of General Practice, 2022, 20(8): 1350-1352, 1356. doi: 10.16766/j.cnki.issn.1674-4152.002594
    [11]
    ZUO A J, ZHAO X Y, LI T T, et al. CTRP9 knockout exaggerates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy through inhibiting the LKB1/AMPK pathway[J]. J Cell Mol Med, 2020, 24(4): 2635-2647. doi: 10.1111/jcmm.14982
    [12]
    何新梅, 陈丹青. 妊娠期糖尿病孕妇血清CTRP6水平及意义[J]. 中华全科医学, 2020, 18(10): 1699-1701. doi: 10.16766/j.cnki.issn.1674-4152.001597

    HE X M, CHEN D Q. Serum CTRP6 level in pregnant women with diabetes during pregnancy and its significance[J]. Chinese Journal of General Practice, 2020, 20(8): 1699-1701. doi: 10.16766/j.cnki.issn.1674-4152.001597
    [13]
    ZAIDI H, BYRKJELAND R, NJERVE I U, et al. Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease[J]. Adipocyte, 2021, 10(1): 612-620. doi: 10.1080/21623945.2021.1996699
    [14]
    BOZZETTO L, POLITO R, NIGRO E, et al. Dietary influence on adiponectin in patients with type 2 diabetes[J]. Eur J Clin Invest, 2021, 51(8): e13548. DOI: 10.1111/eci.13548.
    [15]
    NOMURA H, ARASHI H, YAMAGUCHI J, et al. Relation of adiponectin to cardiovascular events and mortality in patients with acute coronary syndrome[J]. Am J Cardiol, 2021, 140: 7-12. doi: 10.1016/j.amjcard.2020.10.053
    [16]
    LI L, GU Z Y, ZHANG J J. CTRP9 overexpression attenuates palmitic acid-induced inflammation, apoptosis and impaired migration in HTR8/SVneo cells through AMPK/SREBP1c signaling[J]. Exp Ther Med, 2022, 24(1): 459. doi: 10.3892/etm.2022.11386
    [17]
    MORADI N, FADAEI R, EMAMGHOLIPOUR S, et al. Association of circulating CTRP9 with soluble adhesion molecules and inflammatory markers in patients with type 2 diabetes mellitus and coronary artery disease[J]. PLoS One, 2018, 13(1): e0192159. DOI: 10.1371/journal.pone.0192159.
    [18]
    LACROIX M, LIZOTTE F, HIVERT M F, et al. Calcifediol decreases interleukin-6 secretion by cultured human trophoblasts from GDM pregnancies[J]. J Endocr Soc, 2019, 3(11): 2165-2178. doi: 10.1210/js.2019-00181
    [19]
    AMIRIAN A, MAHANI M B, ABDI F. Role of interleukin-6 (IL-6) in predicting gestational diabetes mellitus[J]. Obstet Gynecol Sci, 2020, 63(4): 407-416. doi: 10.5468/ogs.20020
    [20]
    RUSZALA M, NIEBRZYDOWSKA M, PILSZYK A, et al. Novel biomolecules in the pathogenesis of gestational diabetes mellitus[J]. Int J Mol Sci, 2021, 22(21): 11578. DOI: 10.3390/ijms222111578.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (163) PDF downloads(25) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return