Volume 22 Issue 2
Feb.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(2): 195-197
LIU Yuting, SHI Min, CHEN Yanna, YIN Lulu, HU Changjun. Serum levels of C1q/TNF-related protein 9 and its association with insulin resistance in gestational diabetes mellitus[J]. Chinese Journal of General Practice, 2024, 22(2): 195-197. doi: 10.16766/j.cnki.issn.1674-4152.003363
Citation: LIU Yuting, SHI Min, CHEN Yanna, YIN Lulu, HU Changjun. Serum levels of C1q/TNF-related protein 9 and its association with insulin resistance in gestational diabetes mellitus[J]. Chinese Journal of General Practice, 2024, 22(2): 195-197. doi: 10.16766/j.cnki.issn.1674-4152.003363
shu

Serum levels of C1q/TNF-related protein 9 and its association with insulin resistance in gestational diabetes mellitus

doi: 10.16766/j.cnki.issn.1674-4152.003363

  • Department of Endocrinology, the Affiliated Huaian No.1 People' s Hospital of Nanjing Medical University, Huai' an, Jiangsu 223300, China

Funds:

 81700723

  • Received Date: 2023-08-10
    Available Online: 2024-03-27
    Abstract
  •   Objective  To investigate the relationship between serum C1q/tumor necrosis factor-related protein 9 (CTRP9) and gestational diabetes mellitus (GDM) and its clinical significance.  Methods  A total of 35 patients with GDM and 37 pregnant women without the condition were enrolled. The general characteristics, glucose metabolism indicators, serum CTRP9 levels and other adipokine levels were compared between the two groups. In addition, a Pearson correlation analysis was conducted to examine the correlation between serum CTRP9, other cytokines and clinical indexes in pregnant women with GDM.  Results  The fasting plasma glucose (FPG), OGTT 1hPG, OGTT 2hPG, fasting insulin (FINS), HOMA-IR, interleukin-6 (IL-6), leptin, tumor necrosis factor-α (TNF-α), and CTRP9 in the GDM group were higher than those in the control group (P<0.05). The results of the Pearson correlation analysis indicated that serum CTRP9 was positively correlated with FPG, 1hPG, 2hPG, FINS, HOMA-IR, IL-6 and TNF-α (P<0.05). The logistic regression analysis showed that elevated HOMA-IR (OR=14.771, P=0.046) and CTRP9 (OR=4.965, P=0.002) were independent risk factors for GDM. ROC analysis demonstrated that CTRP9 and HOMA-IR had areas under the curve of 0.914 and 0.822, respectively, for diagnosing GDM. The combined detection had an area under the curve of 0.943, indicating optimal diagnostic efficiency.  Conclusion  The serum CTRP9 level is elevated in GDM. Elevated serum CTRP9 level is an independent risk factor for GDM. Furthermore, the combination of serum CTRP9 and HOMA-IR was more efficient in screening for GDM.

     

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