Volume 22 Issue 2
Feb.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(2): 206-208
XU Hongbo, ZHANG Yajun, HUANG Zhifei, ZHAO Hongyu, LIU Zixuan, GAO Bo, CAI Feng, SONG Shilong, HE Zelai, JIANG Hao. Analysis of the short-term efficacy and side effects of concurrent chemoradiotherapy combined with nimotuzumab in patients with locally advanced nasopharyngeal carcinoma[J]. Chinese Journal of General Practice, 2024, 22(2): 206-208. doi: 10.16766/j.cnki.issn.1674-4152.003366
Citation: XU Hongbo, ZHANG Yajun, HUANG Zhifei, ZHAO Hongyu, LIU Zixuan, GAO Bo, CAI Feng, SONG Shilong, HE Zelai, JIANG Hao. Analysis of the short-term efficacy and side effects of concurrent chemoradiotherapy combined with nimotuzumab in patients with locally advanced nasopharyngeal carcinoma[J]. Chinese Journal of General Practice, 2024, 22(2): 206-208. doi: 10.16766/j.cnki.issn.1674-4152.003366
shu

Analysis of the short-term efficacy and side effects of concurrent chemoradiotherapy combined with nimotuzumab in patients with locally advanced nasopharyngeal carcinoma

doi: 10.16766/j.cnki.issn.1674-4152.003366

  • Department of Radiotherapy, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 2020b07030008

 KJ2021A0781

  • Received Date: 2023-09-11
    Available Online: 2024-03-27
    Abstract
  •   Objective  Nasopharyngeal carcinoma has unique anatomical and biological characteristics, and radiotherapy or concurrent chemoradiotherapy is an effective treatment mode. However, many patients with locally advanced nasopharyngeal carcinoma still experience local recurrence or distant metastasis. Therefore, targeted therapy provides an additional option for nasopharyngeal carcinoma patients. This article aims to evaluate the short-term efficacy and toxicity of concurrent chemoradiotherapy combined with nimotuzumab in the treatment of locally advanced nasopharyngeal carcinoma patients, and further analyze the impact of intensity-modulated radiation therapy (IMRT) and helical tomotherapy (TOMO) on patiens' side effects.  Methods  A retrospective analysis was conducted on the clinical data of 88 patients with locally advanced nasopharyngeal carcinoma admitted to the Radiotherapy Department of the First Affiliated Hospital of Bengbu Medical University from December 2020 to June 2023. The treatment group consisted of 44 patients who received concurrent chemoradiotherapy with nimotuzumab targeted therapy, while the control group consisted of 44 patients who only received concurrent chemoradiotherapy. The short-term treatment efficacy, toxic side effects, and the impact of different radiotherapy methods on side effects were compared and analyzed.  Results  In the treatment group, the overall response rate (ORR) for the nasopharyngeal region and cervical lymph nodes were 97.8% (43/44) and 93.2% (41/44) respectively, while in the control group, the ORR were 81.8%(36/44) and 81.8% (36/44) respectively. The incidence of mucositis was higher in the treatment group compared to the control group: 84.1%(37/44) compared to 63.6%(28/44), P<0.05. Further analysis showed that the incidence of mucositis was lower in patients receiving TOMO in both the treatment and control groups than in the IMRT, but the difference was not statistically significant (P>0.05).  Conclusion  For patients with locally advanced nasopharyngeal carcinoma, concurrent chemoradiotherapy with nimotuzumab provides better short-term efficacy, while patients receiving TOMO have a decreasing trend in mucosal reactions.

     

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