Volume 22 Issue 2
Feb.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(2): 244-246
BAI Xiaohui, HONG Luxi. Clinical study of transvaginal ultrasound monitoring of trazole combined with gonadotropin in the treatment of infertility in polycystic ovary syndrome[J]. Chinese Journal of General Practice, 2024, 22(2): 244-246. doi: 10.16766/j.cnki.issn.1674-4152.003375
Citation: BAI Xiaohui, HONG Luxi. Clinical study of transvaginal ultrasound monitoring of trazole combined with gonadotropin in the treatment of infertility in polycystic ovary syndrome[J]. Chinese Journal of General Practice, 2024, 22(2): 244-246. doi: 10.16766/j.cnki.issn.1674-4152.003375
shu

Clinical study of transvaginal ultrasound monitoring of trazole combined with gonadotropin in the treatment of infertility in polycystic ovary syndrome

doi: 10.16766/j.cnki.issn.1674-4152.003375
  • 1.

    Department of Ultrasound, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang 325000, China

Funds:

 2020KY1064

  • Received Date: 2023-10-30
    Available Online: 2024-03-27
    Abstract
  •   Objective  The main treatment drugs for PCOS are letrozole, but the effect of single drug treatment is not good. This study used vaginal ultrasound technology as a means to evaluate the efficacy of letrozole and gonadotropin drug combination in the treatment of infertility patients with PCOS.  Methods  A total of 86 patients with PCOS treated in Wenzhou Hospital of Integrated Chinese and Western Medicine from January to December 2022 were selected and divided into observation group (43 cases) and control group (43 cases) according to random number table method. The control group was treated with letrozole, and the observation group was treated with letrozole combined with human follicle stimulating hormone. Ovarian parameters, including ovarian volume, maximum ovarian follicle diameter, endometrial thickness and number of follicles, were evaluated by transvaginal ultrasound. Peak systolic flow rate, pulsation index and resistance index of ovarian interstitial artery were compared between the two groups. Levels of follicle-stimulating hormone, estradiol and luteinizing hormone, ovulation rate and pregnancy rate were compared between the two groups.  Results  The ovarian volume and number of follicles in observation group were smaller than those in control group, the maximum ovarian follicle diameter and endometrial thickness were larger than those in control group, and the peak systolic flow rate, pulsation index and resistance index of the ovarian interstitial artery were higher than those in control group, with statistical significance (P < 0.05). Follicle stimulating hormone and estradiol in the observation group were (7.88±1.26) mIU/mL and (162.32±20.07) pmol/L, respectively, which were significantly higher than those in the control group [(4.42±0.61) mIU/mL and (62.46±9.28) pmol/L, P < 0.05]. Luteinizing hormone in observation group was significantly lower than that in control group [(6.29±0.78) mIU/mL vs. (18.42±2.15) mIU/mL, P < 0.05]. The ovulation rate and conception rate in the observation group were significantly higher than those of control group (P < 0.05).  Conclusion  Vaginal ultrasound monitoring can provide good feedback on the treatment of PCOS patients, and gonadotropin drug treatment of PCOS can effectively improve the ovulation rate and pregnancy rate of patients, which has good clinical value.

     

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