Volume 22 Issue 3
Mar.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(3): 368-371
WU Long, WU Huan, HUANG Fei, LI Xiaoyun, ZHEN Yunhuan, LI Haiyang. Circulating tumor DNA in colorectal cancer[J]. Chinese Journal of General Practice, 2024, 22(3): 368-371. doi: 10.16766/j.cnki.issn.1674-4152.003404
Citation: WU Long, WU Huan, HUANG Fei, LI Xiaoyun, ZHEN Yunhuan, LI Haiyang. Circulating tumor DNA in colorectal cancer[J]. Chinese Journal of General Practice, 2024, 22(3): 368-371. doi: 10.16766/j.cnki.issn.1674-4152.003404
shu

Circulating tumor DNA in colorectal cancer

doi: 10.16766/j.cnki.issn.1674-4152.003404
  • 1.

    Department of Anus and Intestine Surgery, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China

Funds:

 82060440

 gzwkj2023-042

  • Received Date: 2023-06-27
    Available Online: 2024-05-27
    Abstract
  • Colorectal cancer is a prevalent form of cancer in China and is the second leading cause of death worldwide. The prognosis of the disease has greatly improved with the development of diagnostic techniques and advances in therapeutic methods, including surgery and chemotherapy. However, a certain percentage of patients still experience recurrence after radical treatment circulating tumor DNA (ctDNA) is a cell-free circulating DNA (cfDNA) fragment derived from tumor cells. It is a novel biomarker that can be used to monitor the efficacy of radiotherapy and postoperative recurrence in colorectal cancer patients. Compared to traditional biomarkers, the ctDNA has higher specificity and sensitivity and can be stably present in patients ' serum. Detecting ctDNA levels allows for a more accurate assessment of the patient ' s condition and the formulation of a personalized treatment plan based on test results. The use of ctDNA in the diagnosis and treatment of colorectal cancer offers high specificity and sensitivity. By detecting the level of ctDNA in a patient ' s serum, it is possible determined whether they may have colorectal cancer at an early stage. Meanwhile, by comparing the changes in serum ctDNA levels before and after treatment, the therapeutic effect of patients can be evaluated. In colorectal cancer follow-up, ctDNA has high specificity and sensitivity. By detecting the patient ' s serum ctDNA level, recurrence can be effectively determined. If the serum ctDNA level of the patient continues to increase, it suggests that the patient may have relapsed and requires prompt examination and intervention. In conclusion, ctDNA is a promising biomarker with high specificity and sensitivity. It can be used to monitor the effectiveness of radiotherapy and detect postoperative recurrence in patients with colorectal cancer. It is currently considered one of the novel biomarkers in liquid biopsy. It can be used to assess radiotherapy effect and monitor postoperative recurrence. This makes it a valuable biomarker. This paper presents a review of the characteristics of ctDNA and its applications in the diagnosis, treatment and follow-up of colorectal cancer.

     

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