Volume 22 Issue 3
Mar.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(3): 376-379
LIU Jinghua, WANG Hailing, ZHAO Yang, MA Jianfeng. The expression and correlation between circPRKCI and miR-545 in colorectal cancer[J]. Chinese Journal of General Practice, 2024, 22(3): 376-379. doi: 10.16766/j.cnki.issn.1674-4152.003406
Citation: LIU Jinghua, WANG Hailing, ZHAO Yang, MA Jianfeng. The expression and correlation between circPRKCI and miR-545 in colorectal cancer[J]. Chinese Journal of General Practice, 2024, 22(3): 376-379. doi: 10.16766/j.cnki.issn.1674-4152.003406
shu

The expression and correlation between circPRKCI and miR-545 in colorectal cancer

doi: 10.16766/j.cnki.issn.1674-4152.003406
  • 1.

    Department of Gastroenterology, the Seventh People ' s Hospital of Zhengzhou, Zhengzhou, Henan 450000, China

Funds:

 LHGJ20220205

  • Received Date: 2023-09-05
    Available Online: 2024-05-27
    Abstract
  •   Objective  To investigate the expression of circular RNA PRKCI (circPRKCI) and microrNA-545 (miR-545) in colorectal cancer tissues and their effects on prognosis.  Methods  From March 2013 to April 2018, 102 patients with colorectal cancer underwent surgical resection in Zhengzhou Seventh People ' s Hospital were collected. The expression levels of circPRKCI and miR-545 in colorectal cancer patients with different clinicopathological characteristics were analyzed. The effects of circPRKCI and miR-545 expression levels on the prognosis of patients were analyzed by Cox regression and survival curve.  Results  The expression of circPRKCI was significantly up-regulated in colorectal cancer tissues compared to paracancer tissues (1.47±0.69 vs. 0.82±0.42, t=8.644, P < 0.05). Conversely, miR-545 expression was significantly down-regulated in colorectal cancer tissues (0.86±0.55 vs. 1.60±0.66, t=8.908, P < 0.05). The expression of circPRKCI increased and the expression of miR-545 decreased in patients with lymph node metastasis and TNM stage Ⅲ-Ⅳ (P < 0.05). Furthermore, patients with high expression of circPRKCI and low expression of miR-545 exhibited poor prognosis (P < 0.05). Both circPRKCI and miR-545 were identified as independent risk factors for poor prognosis in patients with colorectal cancer, and their expression showed a negative correlation.  Conclusion  The expression of circPRKCI and miR-545 is related to the adverse pathological parameters and prognosis in patients with colorectal cancer, suggesting a potential regulatory role of circPRKCI in the progression of colorectal cancer involving miR-545.

     

    • FullText(HTML)
  • loading
    • References(17)
  • [1]
    QIU H, CAO S, XU R. Cancer incidence, mortality, and burden in China: a time-trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020[J]. Cancer Commun(Lond), 2021, 41(10): 1037-1048.
    [2]
    郑荣寿, 孙可欣, 张思维, 等. 2015年中国恶性肿瘤流行情况分析[J]. 中华肿瘤杂志, 2019, 41(1): 19-28. doi: 10.3760/cma.j.issn.0253-3766.2019.01.005

    ZHENG R S, SUN K X, ZHANG S W, et al. Report of cancer epidemiology in China, 2015[J]. Chinese Journal of Oncology, 2019, 41(1): 19-28. doi: 10.3760/cma.j.issn.0253-3766.2019.01.005
    [3]
    MILLER K D, NOGUEIRA L, DEVASIA T, et al. Cancer treatment and survivorship statistics, 2022[J]. CA Cancer J Clin, 2022, 72(5): 409-436. doi: 10.3322/caac.21731
    [4]
    李轩, 荣宝海, 解广东, 等. 环状RNA与结直肠癌相关性研究进展[J]. 中国中西医结合外科杂志, 2021, 27(1): 154-158. doi: 10.3969/j.issn.1007-6948.2021.01.031

    LI X, RONG B H, XIE G D, et al. Research progress of correlation between circular RNA and colorectal cancer[J]. Chinese Journal of Surgery of Integrated Traditional and Western Medicine, 2021, 27(1): 154-158. doi: 10.3969/j.issn.1007-6948.2021.01.031
    [5]
    QIU M, XIA W, CHEN R, et al. The circular RNA circPRKCI promotes tumor growth in lung adenocarcinoma[J]. Cancer Res, 2018, 78(11): 2839-2851. doi: 10.1158/0008-5472.CAN-17-2808
    [6]
    QI S X, SUN H, LIU H, et al. Role and mechanism of circ-PRKCI in hepatocellular carcinoma[J]. World J Gastroenterol, 2019, 25(16): 1964-1974. doi: 10.3748/wjg.v25.i16.1964
    [7]
    WU L, LI Y, XU X M, et al. Circular RNA circ-PRKCI promotes cell proliferation and invasion by binding to microRNA-545 in gastric cancer[J]. Eur Rev Med Pharmacol Sci, 2019, 23(21): 9418-9426.
    [8]
    ZHANG X, YANG H, ZHAO L, et al. Circular RNA PRKCI promotes glioma cell progression by inhibiting microRNA-545[J]. Cell Death Dis, 2019, 10(8): 616. DOI: 10.1038/s41419-019-1863-z.
    [9]
    JIA X, LIU X, LI M, et al. Potential tumor suppressing role of microRNA-545 in epithelial ovarian cancer[J]. Oncol Lett, 2018, 15(5): 6386-6392.
    [10]
    CUI J, PAN G, HE Q, et al. MicroRNA-545 targets ZEB2 to inhibit the development of non-small cell lung cancer by inactivating Wnt/β-catenin pathway[J]. Oncol Lett, 2019, 18(3): 2931-2938.
    [11]
    HUANG X, LU S. MicroR-545 mediates colorectal cancer cells proliferation through up-regulating epidermal growth factor receptor expression in HOTAIR long non-coding RNA dependent[J]. Mol Cell Biochem, 2017, 431(1-2): 45-54. doi: 10.1007/s11010-017-2974-4
    [12]
    胡亚男, 王秋童, 何凤蝶, 等. 中国成人自报结直肠癌患者生活方式研究[J]. 中华全科医学, 2023, 21(2): 279-282. doi: 10.16766/j.cnki.issn.1674-4152.002864

    HU Y N, WANG Q T, HE F D, et al. Lifestyle study of Chinese adults with self-reported colorectal cancer[J]. Chinese Journal of General Practice, 2023, 21(2): 279-282. doi: 10.16766/j.cnki.issn.1674-4152.002864
    [13]
    郑磊, 路佳. 单细胞测序技术及其在结直肠癌中的应用[J]. 天津医药, 2021, 49(8): 891-896. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYZ202108023.htm

    ZHENG L, LU J. Single cell sequencing and its application in colorectal cancer[J]. Tianjin Medical Journal, 2021, 49(8): 891-896. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYZ202108023.htm
    [14]
    KRISTENSEN L S, JAKOBSEN T, HAGER H, et al. The emerging roles of circRNAs in cancer and oncology[J]. Nat Rev Clin Oncol, 2022, 19(3): 188-206. doi: 10.1038/s41571-021-00585-y
    [15]
    MA Y, ZHANG D, WU H, et al. Circular RNA PRKCI silencing represses esophageal cancer progression and elevates cell radiosensitivity through regulating the miR-186-5p/PARP9 axis[J]. Life Sci, 2020, 259: 118168. DOI: 10.1016/j.lfs.2020.118168.
    [16]
    VERDUCI L, STRANO S, YARDEN Y, et al. The circRNA-microRNA code: emerging implications for cancer diagnosis and treatment[J]. Mol Oncol, 2019, 13(4): 669-680. doi: 10.1002/1878-0261.12468
    [17]
    TO K K, TONG C W, WU M, et al. MicroRNAs in the prognosis and therapy of colorectal cancer: from bench to bedside[J]. World J Gastroenterol, 2018, 24(27): 2949-2973. doi: 10.3748/wjg.v24.i27.2949
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (122) PDF downloads(9) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return