Volume 22 Issue 3
Mar.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(3): 414-417
WU Daoai, JIN Guoxi, SHI Zhaoming, WU Chenchen, SUN Weihua, CHEN Li. Correlation between time in range and diabetic foot in patients with type 2 diabetes mellitus[J]. Chinese Journal of General Practice, 2024, 22(3): 414-417. doi: 10.16766/j.cnki.issn.1674-4152.003415
Citation: WU Daoai, JIN Guoxi, SHI Zhaoming, WU Chenchen, SUN Weihua, CHEN Li. Correlation between time in range and diabetic foot in patients with type 2 diabetes mellitus[J]. Chinese Journal of General Practice, 2024, 22(3): 414-417. doi: 10.16766/j.cnki.issn.1674-4152.003415
shu

Correlation between time in range and diabetic foot in patients with type 2 diabetes mellitus

doi: 10.16766/j.cnki.issn.1674-4152.003415
  • 1.

    Department of Endocrinology, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 202204295107020049

 2020byzd112

  • Received Date: 2023-05-18
    Available Online: 2024-05-27
    Abstract
  •   Objective  To investigate the correlation between glycemic variability such as time in range (TIR) and diabetic foot (DF).  Methods  The study included 163 inpatients with T2DM who underwent prompt dynamic blood glucose monitoring at the Department of Endocrinology, the First Affiliated Hospital of Bengbu Medical University between January 2020 and December 2020. The participants were divided into two groups based on the presence or absence of DF: the DF group (n=26) and the non-DF group (NDF, n=137). The DF group were divided into two sub-groups based on the Wagner classification: Wagner grade 3 group (n=17), Wagner grade 4 group (n=9). All patients underwent fundus photography and sensory threshold (VPT) measurement, additionally, their glucose levels were monitored using TIR, time above range (TAR), time below range (TBR), glucose coefficient of variation (CV) and mean amplitude of glycemic excursions (MAGE). The above indices were compared statistically.  Results  TIR [(35.19±10.94) % vs. (44.79±10.60) %], CV [36.65 (29.45, 38.75) % vs. 29.90 (24.60, 34.80) %], TAR [(61.46±12.21) % vs.(54.01±11.22) %], TBR [1.00 (0.00, 5.75) % vs. 0.00 (0.00, 1.00) %], fundus photography (19/26 vs. 96/137) and abnormal proportion of VPT (25/26 vs. 45/137), there were statistical differences between the DF and NDF groups. The rates of CRP and VPT were higher in the Wagner grade 3 and 4 groups compared to the NDF group. Additionally, the TIR was lower in both groups compared to the NDF group, with statistically significant differences. The results of the multiple logistic regression analysis indicate that CRP (OR=1.024, P=0.011), fundus radiography (OR=0.113, P=0.013) and VPT (OR=31.803, P=0.042) were independent influencing factors for DF.  Conclusion  DF can be complicated by DM retinopathy and neuropathy, and infection is an independent risk factor. A higher CV was observed with lower TIR, indicating poor and fluctuating blood glucose levels. This may be associated with the development of DF.

     

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