Volume 22 Issue 3
Mar.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(3): 424-428
MA Guojun, LI Yang, FU Jianhua, YANG Dawei. Clinical value of count of circulating tumor cells detection in patients with adenocarcinoma of esophagogastric junction[J]. Chinese Journal of General Practice, 2024, 22(3): 424-428. doi: 10.16766/j.cnki.issn.1674-4152.003417
Citation: MA Guojun, LI Yang, FU Jianhua, YANG Dawei. Clinical value of count of circulating tumor cells detection in patients with adenocarcinoma of esophagogastric junction[J]. Chinese Journal of General Practice, 2024, 22(3): 424-428. doi: 10.16766/j.cnki.issn.1674-4152.003417
shu

Clinical value of count of circulating tumor cells detection in patients with adenocarcinoma of esophagogastric junction

doi: 10.16766/j.cnki.issn.1674-4152.003417
  • 1.

    Department of thoracic Surgery, Liaocheng people ' s Hospital, Liaocheng, Shandong 252000, China

Funds:

 ZR2021MH215

 2022YDSF37

  • Received Date: 2023-07-26
    Available Online: 2024-05-27
    Abstract
  •   Objective  To investigate the relationship between the count of circulating tumor cells (CTCs) in peripheral blood and the clinical characteristics and overall survival (OS) of patients with adenocarcinoma of esophagogastric junction (AEG), and to explore the clinical application value of CTCs detection in AEG patients.  Methods  A total of 154 patients with AEG were eligible for enrollment in Liaocheng People ' s Hospital from July 2016 to June 2020 in the retrospective study. Negative enrichment techniques and fluorescence in situ hybridization (NE-FISH) were used to detect CTCs one week before treatment and the relationship between CTCs count and clinical characteristics of AEG patients was then investigated. Moreover, relationship between CTCs count and OS in prognosis were also explored.  Results  The positive rate of CTCs was 57.1% (32/56) and the positive rates of CEA, CA19-9 and CA72-4 were 19.6% (11/56), 1.8% (1/56) and 12.5% (7/56) respectively in the early AEG patients. The presence of CTCs was significantly correlated with AEG patients, CTCs were positive (≥2) in patients with AEG was significantly correlated with intravascular tumor thrombus (χ2=45.262, P < 0.001), TNM stage (χ2=14.304, P < 0.001)and lymph node metastasis (χ2=5.158, P=0.023). Log-rank univariate analysis showed that CTCs ≥ 2 (χ2=12.486, P < 0.001) and CTCs ≥ 3 (χ2=45.344, P < 0.001) were closely related to OS in AEG patients(P < 0.001). Cox multivariate analysis showed that CTCs ≥ 3 (HR=2.459, 95% CI: 1.472-4.107, P=0.001) was an independent risk factor for the prognosis of OS in AEG patients.  Conclusion  The detection of CTCs by negative enrichment fluorescence in situ hybridization can be used as an auxiliary diagnostic indicator for early AEG patients, which is closely related to the pathological stage of AEG patients and tumor recurrence and metastasis. CTCs ≥ 3 can be used as an independent risk factor for poor prognosis of AEG patients and have a certain clinical application value.

     

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