Value of cTnI, NT-proBNP and CA-125 in diagnosis of pulmonary infection in elderly patients with chronic heart failure

YAO Yao; LU Ning; CHEN Jianguo

doi:10.16766/j.cnki.issn.1674-4152.003421

Volume 22 Issue 3

Mar. 2024

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Article Navigation > Chinese Journal of General Practice > 2024 > 22(3): 440-442

YAO Yao, LU Ning, CHEN Jianguo. Value of cTnI, NT-proBNP and CA-125 in diagnosis of pulmonary infection in elderly patients with chronic heart failure[J]. Chinese Journal of General Practice, 2024, 22(3): 440-442. doi: 10.16766/j.cnki.issn.1674-4152.003421

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YAO Yao, LU Ning, CHEN Jianguo. Value of cTnI, NT-proBNP and CA-125 in diagnosis of pulmonary infection in elderly patients with chronic heart failure[J]. Chinese Journal of General Practice, 2024, 22(3): 440-442. doi: 10.16766/j.cnki.issn.1674-4152.003421

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Value of cTnI, NT-proBNP and CA-125 in diagnosis of pulmonary infection in elderly patients with chronic heart failure

doi: 10.16766/j.cnki.issn.1674-4152.003421

YAO Yao¹
, LU Ning^{1
,
,}
, CHEN Jianguo²

1.
Department of Geriatrics, Wuhu First People ' s Hospital, Wuhu, Anhui 241000, China

Funds:

2008085MH257

Received Date: 2023-11-12
Available Online: 2024-05-27

Abstract

Abstract

Objective To investigate the diagnostic value of cardiac troponin I (cTnI), N-terminal precursor brain natriuretic peptide (NT-proBNP) and carbohydrate antigen-125 (CA-125) in elderly patients with chronic heart failure who have pulmonary infection. Methods During the period between January 2020 and June 2023, we selected 40 elderly patients with chronic heart failure and pulmonary infection as the combined lung infection group, 40 elderly patients with simple heart failure as the simple heart failure group, and 40 elderly patients who underwent physical examination as the control. The study compared the levels of serum cTnI, NT-proBNP, and CA-125 among the three groups, including the group with pulmonary infection. The diagnostic efficiency of serum cTnI, NT-proBNP and CA-125 in patients with pulmonary infection was analyzed by using the ROC curve. Results The levels of serum cTnI, NT-proBNP and CA-125 were higher in patients with pulmonary infection compared to those in the simple heart failure group and control group (P < 0.05). Additionally, the levels of serum cTnI, NT-proBNP and CA-125 were higher in grade Ⅳ patients with pulmonary infection were higher than those in grade Ⅲ and grade Ⅱ, and those in grade Ⅲ were higher than those in grade Ⅱ (P < 0.05). The serum cTnI, NT-proBNP and CA-125 AUC values for diagnosing pulmonary infection with chronic heart failure alone and in combination were 0.935, 0.977, 0.996 and 1.000, respectively (P < 0.05). Conclusion In elderly patients with chronic heart failure and pulmonary infection, serum levels of cTnI, NT-proBNP and CA-125 were found to be abnormally elevated. The combined detection of these three biomarkers could improve the diagnostic efficiency of the disease.
- Elderly chronic heart failure,
- Lung infection,
- Cardiac troponin I,
- N-terminal precursor brain natriuretic peptide,
- Carbohydrate antigen-125

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References(22)

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Value of cTnI, NT-proBNP and CA-125 in diagnosis of pulmonary infection in elderly patients with chronic heart failure

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Value of cTnI, NT-proBNP and CA-125 in diagnosis of pulmonary infection in elderly patients with chronic heart failure

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