Volume 22 Issue 3
Mar.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(3): 447-450
YAN Jing, HOU Yanmiao, WANG Zhenhua. Changes and clinical significance of serum LncRNA NNT-AS1, IL-17A levels in children with refractory mycoplasma pneumonia[J]. Chinese Journal of General Practice, 2024, 22(3): 447-450. doi: 10.16766/j.cnki.issn.1674-4152.003423
Citation: YAN Jing, HOU Yanmiao, WANG Zhenhua. Changes and clinical significance of serum LncRNA NNT-AS1, IL-17A levels in children with refractory mycoplasma pneumonia[J]. Chinese Journal of General Practice, 2024, 22(3): 447-450. doi: 10.16766/j.cnki.issn.1674-4152.003423
shu

Changes and clinical significance of serum LncRNA NNT-AS1, IL-17A levels in children with refractory mycoplasma pneumonia

doi: 10.16766/j.cnki.issn.1674-4152.003423

  • Department of Pediatrics, Zhangjiakou Maternal and Child Health Hospital, Zhangjiakou, Hebei 075000, China

Funds:

 2022533

  • Received Date: 2023-07-31
    Available Online: 2024-05-27
    Abstract
  •   Objective  To investigate the expression and clinical value of serum LncRNA NT-AS1 and interleukin (IL) 17A in children with refractory mycoplasma pneumoniae pneumonia (RMPP).  Methods  A total of 148 children with MPP (MPP group) diagnosed and treated at Zhangjiakou Maternal and Child Health Hospital from February 2021 to March 2022 were selected and divided into RMPP group (48 cases) and non-RMPP group (100 cases) according to whether RMPP occurred. Sixty children who underwent surgery for hydrocele in the same period were selected as the control group. The differences of serum LncRNA NNT-AS1 and IL-17A between all groups were compared. The correlation between serum LncRNA NNT-AS1, IL-17A and inflammatory markers was analyzed by Pearson correlation analysis. Multivariate logistic regression analysis of factors affecting the incidence of RMPP. The predictive value of LncRNA NNT-AS1 and IL-17A in the incidence of RMPP was analyzed by subject operating characteristic curve.  Results  Serum LncRNA NNT-AS1 and IL-17A in the MPP group were higher than those in the control group (P < 0.05). Serum LncRNA NNT-AS1 and IL-17A in the MPP group were positively correlated with CRP, PCT, IL-6 and TNF-α (r=0.623-0.721, P < 0.001). Elevated levels of serum LncRNA NNT-AS1 and IL-17A were independent risk factors for RMPP. The area under the curve of RMPP in MPP children was 0.906, which was better than that of single detection.  Conclusion  The elevated levels of serum LncRNA NNT-AS1 and IL-17A in children with RMPP are independent risk factors for the development of RMPP, and the combined detection of LncRNA NNT-AS1 and IL-17A is helpful in assessing the occurrence of RMPP.

     

    • FullText(HTML)
  • loading
    • References(23)
  • [1]
    TSAI T A, TSAI C K, KUO K C, et al. Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children[J]. J Microbiol Immunol Infect, 2021, 54(4): 557-565. doi: 10.1016/j.jmii.2020.10.002
    [2]
    TONG L, HUANG S, ZHENG C, et al. Refractory Mycoplasma pneumoniae pneumonia in children: early recognition and management[J]. J Clin Med, 2022, 11(10): 234-245.
    [3]
    BRIDGES M C, DAULAGALA A C, KOURTIDIS A. LNCcation: lncRNA localization and function[J]. J Cell Biol, 2021, 220(2): 9045-9062.
    [4]
    MA J, QI G, LI L. LncRNA NNT-AS1 promotes lung squamous cell carcinoma progression by regulating the miR-22/FOXM1 axis[J]. Cell Mol Biol Lett, 2020, 25(6): 34-41.
    [5]
    冯华, 薛洪刚, 徐玉秀. 难治性肺炎支原体肺炎患儿血清长链非编码RNA肺腺癌转移相关转录因子1和烟酰胺核苷酸反义转氢酶RNA1检测的临床意义[J]. 现代检验医学杂志, 2022, 37(4): 7-12, 164. doi: 10.3969/j.issn.1671-7414.2022.04.002

    FENG H, XUE H G, XU Y X, et al. Clinical significance of serumlong non-coding rna metastasis-associated lung adenocarcinoma transcript 1, nicotinamide nucleotide transhydrogenase-antisense RNA1 in children with refractory mycoplasma pneumoniae pneumonia[J]. Journal of Modern Laboratory Medicine, 2022, 37(4): 7-12, 164. doi: 10.3969/j.issn.1671-7414.2022.04.002
    [6]
    BREVI A, COGROSSI L L, GRAZIA G, et al. Much More Than IL-17A: cytokines of the IL-17 family between microbiota and cancer[J]. Front Immunol, 2020, 11(7): 5654-5660.
    [7]
    YANG M, MENG F, WANG K, et al. Interleukin 17A as a good predictor of the severity of Mycoplasma pneumoniae pneumonia in children[J]. Sci Rep, 2017, 7(1): 12934-12944. doi: 10.1038/s41598-017-13292-5
    [8]
    中华医学会儿科学分会呼吸学组, 《中华实用儿科临床杂志》编辑委员会. 儿童肺炎支原体肺炎诊治专家共识(2015年版)[J]. 中华实用儿科临床杂志, 2015, 30(17): 1304-1308. doi: 10.3760/cma.j.issn.2095-428X.2015.17.006

    Respiratory Group, Pediatrics Branch of Chinese Medical Association, Editorial Board of Chinese Clinical Journal of Practical Pediatrics. Expert consensus on diagnosis and treatment of mycoplasma pneumoniae pneumonia in children (2015)[J]. Chinese Journal of Applied Clinical Pediatrics, 2015, 30(17): 1304-1308. doi: 10.3760/cma.j.issn.2095-428X.2015.17.006
    [9]
    张松林, 熊蕾蕾, 余燕娟, 等. 血清IL-6、RANTES与儿童难治性肺炎支原体肺炎的关系[J]. 中华全科医学, 2023, 21(4): 619-621. doi: 10.16766/j.cnki.issn.1674-4152.002944

    ZHANG S L, XIONG L L, YU Y J, et al. Expression of serum IL-6 and RANTES in children with refractory pneumonia caused by mycoplasma pneumoniae and their relationship with prognosis[J]. Chinese Journal of General Practice, 2023, 21(4): 619-621. doi: 10.16766/j.cnki.issn.1674-4152.002944
    [10]
    贺宇杉, 杨梅, 钱素云. 细胞因子对难治性肺炎支原体肺炎的预测作用[J]. 中华儿科杂志, 2021, 59(5): 422-425. doi: 10.3760/cma.j.cn112140-20201125-01056

    HE Y S, YANG M, QIAN S Y. Predictive role of cytokines in children with refractory mycoplasma pneumoniae pneumonia[J]. Chinese Journal of Pediatrics, 2021, 59(5): 422-425. doi: 10.3760/cma.j.cn112140-20201125-01056
    [11]
    HUANG J W, LUO X Y, LI Z H, et al. LncRNA NNT-AS1 regulates the progression of lung cancer through the NNT-AS1/miR-3666/E2F2 axis[J]. Eur Rev Med Pharmacol Sci, 2020, 24(1): 238-248.
    [12]
    GENG Z, WANG X, HAO S, et al. LncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad4[J]. BMC Nephrol, 2021, 22(1): 368-373. doi: 10.1186/s12882-021-02580-y
    [13]
    MEI J, ZHANG Y, LU S, et al. Long non-coding RNA NNT-AS1 regulates proliferation, apoptosis, inflammation and airway remodeling of chronic obstructive pulmonary disease via targeting miR-582-5p/FBXO11 axis[J]. Biomed Pharmacother, 2020, 129(9): 1103-1111.
    [14]
    WANG Y, YANG L, DONG X, et al. Overexpression of NNT-AS1 activates TGF-β signaling to decrease tumor CD4 lymphocyte infiltration in hepatocellular carcinoma[J]. Biomed Res Int, 2020, 20(8): 8216-8121.
    [15]
    QI J, JIA F, TIAN H, et al. Efficacy of gamma globulin combined with azithromycin sequential therapy in the treatment of RMPP and its effect on Th1/Th2 cytokine levels[J]. Comput Math Methods Med, 2022, 20(2): 5162-5171.
    [16]
    CHEN P, HUANG Z, CHEN L, et al. The relationships between LncRNA NNT-AS1, CRP, PCT and their interactions and the refractory mycoplasma pneumoniae pneumonia in children[J]. Sci Rep, 2021, 11(1): 2059-2065. doi: 10.1038/s41598-021-81853-w
    [17]
    YASUDA K, TAKEUCHI Y, HIROTA K. The pathogenicity of Th17 cells in autoimmune diseases[J]. Semin Immunopathol, 2019, 41(3): 283-297. doi: 10.1007/s00281-019-00733-8
    [18]
    FAN H, LU B, YANG D, et al. Distribution and Expression of IL-17 and related cytokines in children with Mycoplasma pneumoniae Pneumonia[J]. Jpn J Infect Dis, 2019, 72(6): 387-393. doi: 10.7883/yoken.JJID.2019.113
    [19]
    MILLS K. IL-17 and IL-17-producing cells in protection versus pathology[J]. Nat Rev Immunol, 2023, 23(1): 38-54. doi: 10.1038/s41577-022-00746-9
    [20]
    ZHAO Y, LUAN H, JIANG H, et al. Gegen Qinlian decoction relieved DSS-induced ulcerative colitis in mice by modulating Th17/Treg cell homeostasis via suppressing IL-6/JAK2/STAT3 signaling[J]. Phytomedicine, 2021, 84(6): 1535-1541.
    [21]
    GHOSH R, DEY R, SAWOO R, et al. Neutralization of IL-17 and treatment with IL-2 protects septic arthritis by regulating free radical production and antioxidant enzymes in Th17 and Tregs: an immunomodulatory TLR2 versus TNFR response[J]. Cell Immunol, 2021, 370(9): 1044-1051.
    [22]
    BAI S, WANG W, YE L, et al. IL-17 stimulates neutrophils to release S100A8/A9 to promote lung epithelial cell apoptosis in Mycoplasma pneumoniae-induced pneumonia in children[J]. Biomed Pharmacother, 2021, 143(5): 1121-1134.
    [23]
    WU M, LAI T, JING D, et al. Epithelium-derived IL17A promotes cigarette smoke-induced inflammation and mucus hyperproduction[J]. Am J Respir Cell Mol Biol, 2021, 65(6): 581-592. doi: 10.1165/rcmb.2020-0424OC
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (134) PDF downloads(4) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return