Volume 22 Issue 3
Mar.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(3): 447-450
YAN Jing, HOU Yanmiao, WANG Zhenhua. Changes and clinical significance of serum LncRNA NNT-AS1, IL-17A levels in children with refractory mycoplasma pneumonia[J]. Chinese Journal of General Practice, 2024, 22(3): 447-450. doi: 10.16766/j.cnki.issn.1674-4152.003423
Citation: YAN Jing, HOU Yanmiao, WANG Zhenhua. Changes and clinical significance of serum LncRNA NNT-AS1, IL-17A levels in children with refractory mycoplasma pneumonia[J]. Chinese Journal of General Practice, 2024, 22(3): 447-450. doi: 10.16766/j.cnki.issn.1674-4152.003423
shu

Changes and clinical significance of serum LncRNA NNT-AS1, IL-17A levels in children with refractory mycoplasma pneumonia

doi: 10.16766/j.cnki.issn.1674-4152.003423

  • Department of Pediatrics, Zhangjiakou Maternal and Child Health Hospital, Zhangjiakou, Hebei 075000, China

Funds:

 2022533

  • Received Date: 2023-07-31
    Available Online: 2024-05-27
    Abstract
  •   Objective  To investigate the expression and clinical value of serum LncRNA NT-AS1 and interleukin (IL) 17A in children with refractory mycoplasma pneumoniae pneumonia (RMPP).  Methods  A total of 148 children with MPP (MPP group) diagnosed and treated at Zhangjiakou Maternal and Child Health Hospital from February 2021 to March 2022 were selected and divided into RMPP group (48 cases) and non-RMPP group (100 cases) according to whether RMPP occurred. Sixty children who underwent surgery for hydrocele in the same period were selected as the control group. The differences of serum LncRNA NNT-AS1 and IL-17A between all groups were compared. The correlation between serum LncRNA NNT-AS1, IL-17A and inflammatory markers was analyzed by Pearson correlation analysis. Multivariate logistic regression analysis of factors affecting the incidence of RMPP. The predictive value of LncRNA NNT-AS1 and IL-17A in the incidence of RMPP was analyzed by subject operating characteristic curve.  Results  Serum LncRNA NNT-AS1 and IL-17A in the MPP group were higher than those in the control group (P < 0.05). Serum LncRNA NNT-AS1 and IL-17A in the MPP group were positively correlated with CRP, PCT, IL-6 and TNF-α (r=0.623-0.721, P < 0.001). Elevated levels of serum LncRNA NNT-AS1 and IL-17A were independent risk factors for RMPP. The area under the curve of RMPP in MPP children was 0.906, which was better than that of single detection.  Conclusion  The elevated levels of serum LncRNA NNT-AS1 and IL-17A in children with RMPP are independent risk factors for the development of RMPP, and the combined detection of LncRNA NNT-AS1 and IL-17A is helpful in assessing the occurrence of RMPP.

     

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