Volume 22 Issue 3
Mar.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(3): 455-459
LI Mei, Mulalibieke Heizhati, SUN Le, WANG Zhongrong, YANG Zhikang, LI Jing, LI Wei, LI Nanfang. The relationship between sodium and potassium intake and mild cognitive impairment in community population[J]. Chinese Journal of General Practice, 2024, 22(3): 455-459. doi: 10.16766/j.cnki.issn.1674-4152.003425
Citation: LI Mei, Mulalibieke Heizhati, SUN Le, WANG Zhongrong, YANG Zhikang, LI Jing, LI Wei, LI Nanfang. The relationship between sodium and potassium intake and mild cognitive impairment in community population[J]. Chinese Journal of General Practice, 2024, 22(3): 455-459. doi: 10.16766/j.cnki.issn.1674-4152.003425
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The relationship between sodium and potassium intake and mild cognitive impairment in community population

doi: 10.16766/j.cnki.issn.1674-4152.003425

  • Hypertension Center of People ' s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, NHC Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region "Hypertension Research Laboratory", Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, Xinjiang 830001, China

Funds:

 20190418

 WJWY-202124

  • Received Date: 2023-02-16
    Available Online: 2024-05-27
    Abstract
  •   Objective  To investigate the association between sodium and potassium intake, as assessed by 24-hour urinary sodium and potassium excretion, and mild cognitive impairment (MCI) in a community population.  Methods  A cross-sectional study was conducted in Emin County from March to June 2019 using multi-level stratified random sampling, a total of 561 community residents aged ≥ 35 years were included in this study. The mini-mental state examination (MMSE) was used to assess cognitive function. The subjects were divided into three groups according to 24-hour urinary potassium interquartile grouping: the lowest group (T1, n=187), the middle group (T2, n=187) and the highest group (T3, n=187). Multivariate linear regression model analysis and logistic regression model were used to analyze the risk of MCI.  Results  Twenty-four-hour urinary potassium total MMSE score was lower in the T1 group than in the T3 group [25.0 (20.0, 28.0) vs. 27.0 (24.0, 29.0), P=0.009], and the prevalence of MCI was significantly lower in the T3 group than in the T1 group (9.1% vs. 24.6%, P < 0.001). Multivariate linear regression analysis showed that 24-hour urinary potassium was positively correlated with MMSE (β=0.027, 95% CI: 0.000 to 0.054, P=0.047) and 24-hour urinary sodium was negatively correlated with MMSE (β=-0.007, 95% CI: -0.013 to -0.001, P=0.025). Multivariate logistic regression analysis showed that T1 and T2 groups with lower 24-hour urinary potassium increased the risk of MCI compared with T3 group with higher urinary potassium excretion by 3.222 times (95% CI: 1.577 to 6.562, P=0.001) and 3.022 times (95% CI: 1.513 to 6.029, P=0.002), respectively. The risk of MCI in the T2 group with higher 24-hour urinary sodium was 2.812 times (95% CI: 1.502 to 5.256, P=0.001) compared with the T1 group with lower urinary sodium.  Conclusion  Higher sodium intake and lower potassium intake were independently associated with MCI.

     

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