Volume 22 Issue 3
Mar.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(3): 460-463
LI Qun, LYU Yunxiang, XIA Shenhong, LI Ziguang, ZHANG Yong, SHAO Lu. Clinical value of serum PCT, CRP and IDO levels in predicting prognosis in patients with community-acquired pneumonia[J]. Chinese Journal of General Practice, 2024, 22(3): 460-463. doi: 10.16766/j.cnki.issn.1674-4152.003426
Citation: LI Qun, LYU Yunxiang, XIA Shenhong, LI Ziguang, ZHANG Yong, SHAO Lu. Clinical value of serum PCT, CRP and IDO levels in predicting prognosis in patients with community-acquired pneumonia[J]. Chinese Journal of General Practice, 2024, 22(3): 460-463. doi: 10.16766/j.cnki.issn.1674-4152.003426
shu

Clinical value of serum PCT, CRP and IDO levels in predicting prognosis in patients with community-acquired pneumonia

doi: 10.16766/j.cnki.issn.1674-4152.003426
  • 1.

    Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, China

Funds:

 1804h08020287

  • Received Date: 2023-07-21
    Available Online: 2024-05-27
    Abstract
  •   Objective  To investigate the clinical value of serum levels of procalcitonin (PCT), C-reactive protein (CRP) and indoleamine 2, 3-dioxygenase (IDO) in patients with community-acquired pneumonia (CAP).  Methods  A total of 100 patients with a definite diagnosis of CAP and 40 healthy subjects were enrolled in the Second Affiliated Hospital of Bengbu Medical College from October 2019 to September 2021. According to CURB-65 criteria, patients with CAP were allocated into three groups: the low-risk group (38 cases), the moderate-risk group (32 cases), and the high-risk group (30 cases). Healthy subjects were served as the control group (40 cases). Serum PCT, CRP and IDO levels of all subjects were measured, and assessed their correlation. Serum PCT and IDO levels were applied to predict patient mortality.  Results  Serum levels of PCT, CRP and IDO in patients with CAP significantly increased compared to that of control subjects (P < 0.001). Additionally, serum PCT, CRP and IDO levels of patients with CAP in the high-risk group were significantly elevated relative to that in the moderate-risk group (P < 0.001). Meanwhile, serum PCT, CRP and IDO levels of patients with CAP in the low-risk group were significantly decreased compared with that in moderate-risk group and high-risk group (P < 0.001). Serum IDO levels were positively correlated with CURB-65 score (r=0.750, P < 0.001). Serum IDO levels were positively correlated with PCT and CRP levels (r=0.724, P < 0.001; r=0.634, P < 0.001). PCT combined with IDO predicted a significantly higher 28-day ICU admission rate or mortality in CAP patients (AUC=0.913, P < 0.05).  Conclusion  Serum levels of PCT, CRP and IDO are significantly increased in patients with CAP. Serum IDO levels is positive correlation with CURB-65 score, serum levels of PCT and CRP. Serum PCT combined with IDO levels predicted 28-day ICU admission rate or mortality is more accurately.

     

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