Volume 22 Issue 3
Mar.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(3): 478-480
WANG Hao, LAI Dahai, HUANG Shuaishuai, JIN Aihui, XU Chenlong, CEN Dong. Application of combined detection of MA, BUN, sCr and eGFR in early renal graft injury induced by tacrolimus[J]. Chinese Journal of General Practice, 2024, 22(3): 478-480. doi: 10.16766/j.cnki.issn.1674-4152.003430
Citation: WANG Hao, LAI Dahai, HUANG Shuaishuai, JIN Aihui, XU Chenlong, CEN Dong. Application of combined detection of MA, BUN, sCr and eGFR in early renal graft injury induced by tacrolimus[J]. Chinese Journal of General Practice, 2024, 22(3): 478-480. doi: 10.16766/j.cnki.issn.1674-4152.003430
shu

Application of combined detection of MA, BUN, sCr and eGFR in early renal graft injury induced by tacrolimus

doi: 10.16766/j.cnki.issn.1674-4152.003430
  • 1.

    Department of Clinical Labortary, Ningbo Hospital of Urinary Nephropathy, Ningbo, Zhejiang 315100, China

Funds:

 2022KY1177

 2023J233

  • Received Date: 2023-11-29
    Available Online: 2024-05-27
    Abstract
  •   Objective  To assess the clinical value of early detection of the risk of graft dysfunction in post-renal transplant patients after continued use of tacrolimus (Tac) by combined detection of urinary microalbumin (MA), blood urea nitrogen (BUN), serum creatinine (sCr) and estimated glomerular filtration rate (eGFR).  Methods  Fifty-four renal transplant patients who had been using Tac for a long time and were admitted to Ningbo Hospital for urinary nephropathy between August 2015 and July 2020 were selected. The patients were divided into two groups: group A, which used Tac continuously for 12 months, and group B, which used Tac continuously for 24 months. The clinical value of MA, BUN, sCr, eGFR and combined detection were evaluated through comparative analysis.  Results  Compared to group A, group B showed significant differences in MA and eGFR (P < 0.05), but not in BUN and sCr (P > 0.05). There was a negative correlation between eGFR and MA, BUN and sCr [r values of 12 months (group A) and 24 months (group B) were-0.413, -0.538, -0.797 (P < 0.01) and -0.333, -0.647, -0.738 (P < 0.05), respectively], and was significantly correlated with Tac duration, particularly in the early post-transplantation period. Based on the receiver operating characteristic curve, the AUC for MA, BUN, sCr and eGFR individually were 0.680, 0.594, 0.581 and 0.689, respectively. The combined detection of the four indicators resulted in an AUC of 0.839.  Conclusion  The detection of four renal injury markers (MA, BUN, sCr and eGFR) can aid in the early diagnosis of renal insufficiency in patients who continue to use Tac after renal transplantation.

     

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    • References(20)
  • [1]
    LAI X Q, ZHENG X, MATHEW J M, et al. Tackling chronic kidney transplant rejection: challenges and promises[J]. Front Immunol, 2021, 12: 661643. DOI: 10.3389/fimmu.2021.661643.
    [2]
    BAUER A C, FRANCO R F, MANFRO R C. Immunosuppression in kidney transplantation: state of the art and current protocols[J]. Curr Pharm Des, 2020, 26(28): 3440-3450. doi: 10.2174/1381612826666200521142448
    [3]
    BANAS B, KRǍMER B K, KRÜGER B, et al. Long-term kidney transplant outcomes: role of prolonged-release tacrolimus[J]. Transplant Proc, 2020, 52(1): 102-110. doi: 10.1016/j.transproceed.2019.11.003
    [4]
    TOWNAMCHAI N, AVIHINGSANON Y. Updated management for antibody-mediated rejection: opportunity to prolong kidney allograft survival[J]. Curr Opin Nephrol Hypertens, 2023, 32(1): 13-19. doi: 10.1097/MNH.0000000000000843
    [5]
    RONG Y, MAYO P, ENSOM M H H, et al. Population pharmacokinetics of mycophenolic acid Co-administered with tacrolimus in corticosteroid-free adult kidney transplant patients[J]. Clin Pharmacokinet, 2019, 58(11): 1483-1495. doi: 10.1007/s40262-019-00771-3
    [6]
    李圣冰, 陈文, 李修彬, 等. Multi-Latex多聚粒技术联合检测尿微量蛋白在肾移植术后无创诊断中的应用价值[J]. 器官移植, 2020, 11(4): 443-448. doi: 10.3969/j.issn.1674-7445.2020.04.003

    LI S B, CHEN W, LI X B, et al. Application value of Multi-Latex technique combined with detection of urinary microprotein in non-invasive diagnosis of renal transplantation[J]. Organ transplantation, 2020, 11(4): 443-448. doi: 10.3969/j.issn.1674-7445.2020.04.003
    [7]
    WEINGART C, WIRNSBERGER G H. Clinical implications of the estimated glomerular filtration rate[J]. Z Gerontol Geriatr, 2021, 54(3): 205-210. doi: 10.1007/s00391-021-01839-1
    [8]
    SHI B Y, YUAN M. Guidelines for the treatment of immunosuppression in Chinese kidney transplant recipients[J]. Organ transplantation, 2016, 7(5): 327-331. doi: 10.3969/j.issn.1674-7445.2016.05.001
    [9]
    王学晶. 临床实验室应关注估算肾小球滤过率的报告[J]. 中华检验医学杂志, 2016, 39(12): 888-891. doi: 10.3760/cma.j.issn.1009-9158.2016.12.005

    WANG X J. Clinical laboratory should pay attention to the report of estimated glomerular filtration rate[J]. Chin J Lab Med, 2016, 39(12): 888-891. doi: 10.3760/cma.j.issn.1009-9158.2016.12.005
    [10]
    MǍRUNTELU I, NISTOR C E, CRISTEA B M, et al. Retrospective study from a single center in Romania of 347 renal transplant patients treated with tacrolimus, mycophenolate, and steroids to evaluate the association between anti-HLA antibodies and 5-year graft survival[J]. Ann Transplant, 2022, 27: e937267. DOI: 10.12659/AOT.937267.
    [11]
    XUE W J, TIAN P X, XIANG H L, et al. Outcomes for primary kidney transplantation from donation after citizens death in China: a single center experience of 367 cases[J]. BMC Health Serv Res, 2017, 17(1): 250. doi: 10.1186/s12913-017-2190-7
    [12]
    SENEV A, COEMANS M, LERUT E, et al. Eplet mismatch load and De novo occurrence of donor-specific anti-HLA antibodies, rejection, and graft failure after kidney transplantation: an observational cohort study[J]. J Am Soc Nephrol, 2020, 31(9): 2193-2204. doi: 10.1681/ASN.2020010019
    [13]
    KOROGIANNOU M, ALEXANDROU M E, SARAFIDIS P, et al. Sex-related short-term blood pressure variability differences in kidney transplant recipients[J]. Blood Press Monit, 2022, 27(6): 371-377. doi: 10.1097/MBP.0000000000000621
    [14]
    李泉源, 严礼琴, 魏涧, 等. 肾移植术后出现严重感染的原因及转归分析[J]. 中华全科医学, 2018, 16(6): 889-891. doi: 10.16766/j.cnki.issn.1674-4152.000243

    LI Q Y, YAN L Q, WEI J, et al. The reasons for serious infections and outcome analysis after renal transplantation[J]. Chinese Journal of General Practice, 2018, 16(6): 889-891. doi: 10.16766/j.cnki.issn.1674-4152.000243
    [15]
    BENTATA Y. Tacrolimus: 20 years of use in adult kidney transplantation[J]. Artif Organs, 2020, 44(2): 140-152. doi: 10.1111/aor.13551
    [16]
    CHEUNG C Y, TANG S C W. Personalized immunosuppression after kidney transplantation[J]. Nephrology, 2022, 27(6): 475-483. doi: 10.1111/nep.14035
    [17]
    MACIEL N B, SCHWAMBACH K H, BLATT C R. Liver Transplantation: tacrolimus blood levels variation and survival, rejection and death outcome[J]. Arq Gastroenterol, 2021, 58(3): 370-376. doi: 10.1590/s0004-2803.202100000-62
    [18]
    ONG S C, GASTON R S. Thirty years of tacrolimus in clinical practice[J]. Transplantation, 2021, 105(3): 484-495. doi: 10.1097/TP.0000000000003350
    [19]
    ZHANG L, ZHANG T J, LI Y, et al. Shenqi Yanshen formula (SQYSF) protects against chronic kidney disease by modulating gut microbiota[J]. Bioengineered, 2022, 13(3): 5625-5637. doi: 10.1080/21655979.2021.2023789
    [20]
    LASZCZYNSKA O, SEVERO M, MASCARENHAS J, et al. Serum creatinine trajectories in real-world hospitalized patients: clinical context and short-term mortality[J]. J Investig Med, 2020, 68(4): 870-881. doi: 10.1136/jim-2019-001185
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