Volume 22 Issue 3
Mar.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(3): 478-480
WANG Hao, LAI Dahai, HUANG Shuaishuai, JIN Aihui, XU Chenlong, CEN Dong. Application of combined detection of MA, BUN, sCr and eGFR in early renal graft injury induced by tacrolimus[J]. Chinese Journal of General Practice, 2024, 22(3): 478-480. doi: 10.16766/j.cnki.issn.1674-4152.003430
Citation: WANG Hao, LAI Dahai, HUANG Shuaishuai, JIN Aihui, XU Chenlong, CEN Dong. Application of combined detection of MA, BUN, sCr and eGFR in early renal graft injury induced by tacrolimus[J]. Chinese Journal of General Practice, 2024, 22(3): 478-480. doi: 10.16766/j.cnki.issn.1674-4152.003430
shu

Application of combined detection of MA, BUN, sCr and eGFR in early renal graft injury induced by tacrolimus

doi: 10.16766/j.cnki.issn.1674-4152.003430
  • 1.

    Department of Clinical Labortary, Ningbo Hospital of Urinary Nephropathy, Ningbo, Zhejiang 315100, China

Funds:

 2022KY1177

 2023J233

  • Received Date: 2023-11-29
    Available Online: 2024-05-27
    Abstract
  •   Objective  To assess the clinical value of early detection of the risk of graft dysfunction in post-renal transplant patients after continued use of tacrolimus (Tac) by combined detection of urinary microalbumin (MA), blood urea nitrogen (BUN), serum creatinine (sCr) and estimated glomerular filtration rate (eGFR).  Methods  Fifty-four renal transplant patients who had been using Tac for a long time and were admitted to Ningbo Hospital for urinary nephropathy between August 2015 and July 2020 were selected. The patients were divided into two groups: group A, which used Tac continuously for 12 months, and group B, which used Tac continuously for 24 months. The clinical value of MA, BUN, sCr, eGFR and combined detection were evaluated through comparative analysis.  Results  Compared to group A, group B showed significant differences in MA and eGFR (P < 0.05), but not in BUN and sCr (P > 0.05). There was a negative correlation between eGFR and MA, BUN and sCr [r values of 12 months (group A) and 24 months (group B) were-0.413, -0.538, -0.797 (P < 0.01) and -0.333, -0.647, -0.738 (P < 0.05), respectively], and was significantly correlated with Tac duration, particularly in the early post-transplantation period. Based on the receiver operating characteristic curve, the AUC for MA, BUN, sCr and eGFR individually were 0.680, 0.594, 0.581 and 0.689, respectively. The combined detection of the four indicators resulted in an AUC of 0.839.  Conclusion  The detection of four renal injury markers (MA, BUN, sCr and eGFR) can aid in the early diagnosis of renal insufficiency in patients who continue to use Tac after renal transplantation.

     

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