Venetoclax combined with azacitidine in treatment of acute megakaryoblastic leukemia transformed from primary myelofibrosis: report of 1 case and review of literature

WEI Xiaofang; FENG Youfan; DING Guosheng; FU Yuan; CHEN Yang; ZHANG Qike

doi:10.16766/j.cnki.issn.1674-4152.003441

Volume 22 Issue 3

Mar. 2024

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Article Navigation > Chinese Journal of General Practice > 2024 > 22(3): 526-529

WEI Xiaofang, FENG Youfan, DING Guosheng, FU Yuan, CHEN Yang, ZHANG Qike. Venetoclax combined with azacitidine in treatment of acute megakaryoblastic leukemia transformed from primary myelofibrosis: report of 1 case and review of literature[J]. Chinese Journal of General Practice, 2024, 22(3): 526-529. doi: 10.16766/j.cnki.issn.1674-4152.003441

Citation:

WEI Xiaofang, FENG Youfan, DING Guosheng, FU Yuan, CHEN Yang, ZHANG Qike. Venetoclax combined with azacitidine in treatment of acute megakaryoblastic leukemia transformed from primary myelofibrosis: report of 1 case and review of literature[J]. Chinese Journal of General Practice, 2024, 22(3): 526-529. doi: 10.16766/j.cnki.issn.1674-4152.003441

Citation:

WEI Xiaofang, FENG Youfan, DING Guosheng, FU Yuan, CHEN Yang, ZHANG Qike. Venetoclax combined with azacitidine in treatment of acute megakaryoblastic leukemia transformed from primary myelofibrosis: report of 1 case and review of literature[J]. Chinese Journal of General Practice, 2024, 22(3): 526-529. doi: 10.16766/j.cnki.issn.1674-4152.003441

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Venetoclax combined with azacitidine in treatment of acute megakaryoblastic leukemia transformed from primary myelofibrosis: report of 1 case and review of literature

doi: 10.16766/j.cnki.issn.1674-4152.003441

1.
Department of Hematology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, China

Funds:

18GSSY4-34

22JR5RA660

Received Date: 2023-01-02
Available Online: 2024-05-27

Abstract

Abstract

We retrospectively analyzed the clinical data of an elderly patient of acute megakaryoblastic leukemia transformed from primary myelofibrosis treated with venetoclax combined with azacitidine in Gansu Provincial People' s Hospital and reviewed the relevant literature. This patient, a 72-year-old man, was diagnosed with primary myelofibrosis and was transformed to acute megakaryoblastic leukemia after 2 years of treatment with ruxolitinib, then given venetoclax combined with azacitidine. After the first course of treatment, the patient had partial remission of bone marrow and clinical improvement significantly. After the second course of treatment, although the bone marrow had complete remission and flow minimal residual disease (MRD) was negative, agranulocytosis persisted for up to 45 days and finally died due to infection.
- Venetoclax,
- Azacitidine,
- Primary myelofibrosis,
- Acute megakaryoblastic leukemia

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References(24)

References

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Venetoclax combined with azacitidine in treatment of acute megakaryoblastic leukemia transformed from primary myelofibrosis: report of 1 case and review of literature

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Venetoclax combined with azacitidine in treatment of acute megakaryoblastic leukemia transformed from primary myelofibrosis: report of 1 case and review of literature

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