Volume 22 Issue 4
Apr.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(4): 548-550
XU Hongzhou, TAO Yanyan, LU Guoyu, WU Xiaofei. Application of lipoprotein a, fibrinogen and C-reactive protein in early diagnosis of coronary heart disease[J]. Chinese Journal of General Practice, 2024, 22(4): 548-550. doi: 10.16766/j.cnki.issn.1674-4152.003446
Citation: XU Hongzhou, TAO Yanyan, LU Guoyu, WU Xiaofei. Application of lipoprotein a, fibrinogen and C-reactive protein in early diagnosis of coronary heart disease[J]. Chinese Journal of General Practice, 2024, 22(4): 548-550. doi: 10.16766/j.cnki.issn.1674-4152.003446
shu

Application of lipoprotein a, fibrinogen and C-reactive protein in early diagnosis of coronary heart disease

doi: 10.16766/j.cnki.issn.1674-4152.003446

  • Department of Emergency Internal Medicine, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 KJ2021ZD0083

 2021byzd157

  • Received Date: 2023-11-08
    Available Online: 2024-05-29
    Abstract
  •   Objective  To investigate the application value of serum lipoprotein a (Lpa), plasma fibrinogen (FIB) and C-reactive protein (CRP) levels in the diagnosis of coronary heart disease (CHD).  Methods  Forty-three patients with CHD who received medical treatment in the First Affiliated Hospital of Bengbu Medical University from March 2020 to May 2021 were selected as the experimental group, and 45 healthy volunteers who received normal coronary angiography results in the same hospital during the same period were selected as the control group. Volunteers served as the control group. The clinical data of the two groups were compared. The plasma levels of Lpa, FIB and CRP were measured using the immunoturbidimetric method, coagulation method and immunoturbidimetric method, respectively, and a comparison of their levels was made between the CHD group and the control group. The optimal threshold for CHD diagnosis was determined by analyzing the individual diagnostic value of each indicator and the combined diagnostic value of the three through the ROC curve analysis.  Results  The levels of Lpa, FIB and CRP in the CHD group were higher than those in the control group (P < 0.05). The AUC of serum Lpa, FIB, and CRP for diagnosing CHD were 0.771 (95% CI: 0.674-0.868), 0.749 (95% CI: 0.640-0.859), and 0.791 (95% CI: 0.697-0.886), respectively, with sensitivities of 53.13%, 50.00%, 59.38% and specificities of 81.08%, 78.39%, 78.29%. The combined detection of the three to diagnose CHD area had an AUC of 0.884 (95% CI: 0.813-0.956), a sensitivity of 81.25%, and a specificity of 78.29%. The combined detection of serum Lpa, FIB, and CRP was better than individual detection.  Conclusion  The combined detection of Lpa, FIB and CRP can improve the sensitivity of CHD diagnosis and facilitate the early detection, thereby enabling proactive intervention to mitigate the development of the disease.

     

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    • References(20)
  • [1]
    GOULD K L, JOHNSON N P. A fundamental principle of coronary pathophysiology for risk stratifying coronary artery disease[J]. Eur Heart J-Card Img, 2021, 22(6): 647-649.
    [2]
    FELDMAN D I, LATINA J, LOVELL J, et al. Coronary computed tomography angiography in patients with stable coronary artery disease[J]. Trends Cardiovasc Med, 2022, 32(7): 421-428. doi: 10.1016/j.tcm.2021.08.009
    [3]
    GU J X, HUANG J, LI S S, et al. Elevated lipoprotein(a) and genetic polymorphisms in the LPA gene may predict cardiovascular events[J]. Sci Rep, 2022, 12(1): 1-13. doi: 10.1038/s41598-021-99269-x
    [4]
    张祥, 许宁, 甄晓玲, 等. 冠心病患者血清D-二聚体、脂蛋白相关磷脂酶A2与不规则趋化因子的表达及其对早期冠心病诊断的临床意义[J]. 实用预防医学, 2019, 26(9): 1142-1145. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYY201909034.htm

    ZHANG X, XU N, ZHEN X L, et al. Expression of serum D-dimer, lipoprotein-associated phospholipase A2 and fractalkine in patients with coronary heart disease (CHD) and their clinical values in the diagnosis of early CHD[J]. Practical Preventive Medicine, 2019, 26(9): 1142-1145. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYY201909034.htm
    [5]
    OLGA I A, ALEXANDRA V T, ELENA A K, et al. Lipoprotein(a), immune cells and cardiovascular outcomes in patients with premature coronary heart disease[J]. J Pers Med, 2022, 12(2): 269. DOI: 10.3390/jpm12020269.
    [6]
    陶斯阳, 马晶茹. 代谢性炎症与冠心病发病机制研究的进展[J]. 沈阳医学院学报, 2023, 25(4): 337-340, 373. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYX202304001.htm

    TAO S Y, MA J R. Progress in studying metabolic inflammation and the pathogenesis of coronary heart disease[J]. Journal of Shenyang Medical College, 2023, 25(4): 337-340, 373. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYX202304001.htm
    [7]
    张艳达, 隋汝杰, 赵健, 等. 冠状动脉微循环障碍: 非阻塞性冠心病潜在发病机制[J]. 第二军医大学学报, 2020, 41(3): 315-320. https://www.cnki.com.cn/Article/CJFDTOTAL-DEJD202003015.htm

    ZHANG Y D, SUI R J, ZHAO J, et al. Coronary microvascular dysfunction: the potential mechanism of non-obstructive coronary artery disease[J]. Journal of the Second Military Medical University, 2020, 41(3): 315-320. https://www.cnki.com.cn/Article/CJFDTOTAL-DEJD202003015.htm
    [8]
    陈建华, 刘艳影. 冠心病患者CRP、PCT、SAA水平与冠状动脉粥样硬化程度的相关性分析[J]. 现代诊断与治疗, 2022, 33(2): 271-273, 290. https://www.cnki.com.cn/Article/CJFDTOTAL-XDZD202202040.htm

    CHEN J H, LIU Y Y. Correlation analysis between CRP, PCT, and SAA levels and coronary atherosclerosis degree in coronary artery disease[J]. Modern Diagnosis and Treatment, 2022, 33(2): 271-273, 290. https://www.cnki.com.cn/Article/CJFDTOTAL-XDZD202202040.htm
    [9]
    刘帅, 林闽江, 许亚飞. 冠状动脉CT血管造影定量分析预测冠心病患者心血管事件风险的价值[J]. 中华全科医学, 2019, 17(8): 1320-1322, 1407. doi: 10.16766/j.cnki.issn.1674-4152.000933

    LIU S, LIN M J, XU Y F. The predictive value of coronary artery CTA quantitative indexes on long-term cardiovascular events in patients with coronary heart disease[J]. Chinese Journal of General Practice, 2019, 17(8): 1320-1322, 1407. doi: 10.16766/j.cnki.issn.1674-4152.000933
    [10]
    GRAY A J, ROOBOTTOM C, SMITH J E, et al. Early computed tomography coronary angiography in adults presenting with suspected acute coronary syndrome: the RAPID-CTCA RCT[J]. Health Technol Assess, 2022, 26(37): 1-114. doi: 10.3310/IRWI5180
    [11]
    WEI W Q, LI X, FENG Q, et al. LPA variants are associated with residual cardiovascular risk in patients receiving statins[J]. Circulation, 2018, 138(17): 1839-1849. doi: 10.1161/CIRCULATIONAHA.117.031356
    [12]
    樊碧娆, 姚伟娟. 氧化型低密度脂蛋白受体在动脉粥样硬化发病机制中的作用[J]. 中国病理生理杂志, 2020, 36(10): 1897-1901. https://www.cnki.com.cn/Article/CJFDTOTAL-ZBLS202010024.htm

    FAN B R, YAO W J. Role of receptors for oxidized low-density lipoprotein in pathogenesis of atherosclerosis[J]. The Chinese Journal of Pathophysiology, 2020, 36(10): 1897-1901. https://www.cnki.com.cn/Article/CJFDTOTAL-ZBLS202010024.htm
    [13]
    贾曼华, 王国忠, 闫建颖, 等. 冠心病患者血清超敏C反应蛋白及脂蛋白相关磷脂酶A2水平与冠心病纤维脂质斑块纤维帽厚度的关系[J]. 中国介入心脏病学杂志, 2022, 30(5): 355-358. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJXB202205006.htm

    JIA M H, WANG G Z, YAN J Y, et al. The relationship between serum hypersensitive C-reactive protein and lipoprorein-assoeiated phosPhohPaseA2 levels in patients with coronary heart disease and the thickness of fi brous cap of fibrolipid plaques in coronary heart disease[J]. Chinese Journal of Interventional Cardiology, 2022, 30(5): 355-358. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJXB202205006.htm
    [14]
    邸云峰, 李德才, 张大勇. 血清锌指样转录因子2和脂蛋白相关磷脂酶A2水平与冠心病冠状动脉狭窄程度的相关性[J]. 中国临床研究, 2020, 33(7): 952-954, 958. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGCK202007020.htm

    DI Y F, LI D C, ZHANG D Y. Correlation between serum Krüppel-like factor 2 and lipoprotein-associated phospholipase A2 levels and degree of coronary stenosisin patients with coronary heart disease[J]. Chinese Journal of Clinical Research, 2020, 33(7): 952-954, 958. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGCK202007020.htm
    [15]
    DYKUN I, KAMPF J, RASSAF T, et al. Interaction between elevated lipoprotein(a) and LDL-cholesterol on mortality risk in patients with coronary artery disease[J]. Eur J Prev Cardiol, 2023, 30(13): 64-65. doi: 10.1093/eurjpc/zwad059
    [16]
    KURL S, JAE S Y, VOUTILAINEN A, et al. The combined effect of blood pressure and C-reactive protein with the risk of mortality from coronary heart and cardiovascular diseases[J]. Nutr Metab Cardiovasc Dis, 2021, 31(7): 2051-2057. doi: 10.1016/j.numecd.2021.04.004
    [17]
    WARD-CAVINESS C K, DE VRIES P S, WIGGINS K L, et al. Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease[J]. PLoS One, 2019, 14(5): e0216222. DOI: 10.1371/journal.pone.0216222.
    [18]
    于瑞杰, 徐敏. 冠心病患者D-二聚体、纤维蛋白原和超敏C反应蛋白的关系研究[J]. 医学检验与临床, 2023, 34(6): 21-24. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWX201412012.htm

    YU R J, XU M. Research on relationship between the levels of D-dimer, fibrinogen and hypersensitivity C-reactive protein in patients with coronary heart disease[J]. Medical Laboratory Science and Clinics, 2023, 34(6): 21-24. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWX201412012.htm
    [19]
    邹甜甜, 费安兴, 高淑珍, 等. 老年糖尿病合并冠心病病人MMP-9、D-D、Fib水平变化及临床意义[J]. 中西医结合心脑血管病杂志, 2018, 16(18): 2682-2685. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYY201818024.htm

    ZOU T T, FEI A X, GAO S Z, et al. Changes and clinical significance of MMP-9、D-D、Fib levels in elderly patients with diabetes and coronary heart disease[J]. Chinese Journal of Integrative Medicine on Cardio/Cerebrovascular Disease, 2018, 16(18): 2682-2685. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYY201818024.htm
    [20]
    张瑾, 陶诗怡, 王子涵, 等. 纤维蛋白原与早发冠心病患病及早发冠心病痰湿证的关系[J]. 心脏杂志, 2023, 35(2): 177-182. https://www.cnki.com.cn/Article/CJFDTOTAL-XGNZ202302011.htm

    ZHANG J, TAO S Y, WANG Z H, et al. The Relationship between Fibrinogen and Early Coronary Heart Disease and Phlegm Dampness Syndrome[J]. Chinese Heart Journal, 2023, 35(2): 177-182. https://www.cnki.com.cn/Article/CJFDTOTAL-XGNZ202302011.htm
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