Volume 22 Issue 4
Apr.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(4): 548-550
XU Hongzhou, TAO Yanyan, LU Guoyu, WU Xiaofei. Application of lipoprotein a, fibrinogen and C-reactive protein in early diagnosis of coronary heart disease[J]. Chinese Journal of General Practice, 2024, 22(4): 548-550. doi: 10.16766/j.cnki.issn.1674-4152.003446
Citation: XU Hongzhou, TAO Yanyan, LU Guoyu, WU Xiaofei. Application of lipoprotein a, fibrinogen and C-reactive protein in early diagnosis of coronary heart disease[J]. Chinese Journal of General Practice, 2024, 22(4): 548-550. doi: 10.16766/j.cnki.issn.1674-4152.003446
shu

Application of lipoprotein a, fibrinogen and C-reactive protein in early diagnosis of coronary heart disease

doi: 10.16766/j.cnki.issn.1674-4152.003446

  • Department of Emergency Internal Medicine, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 KJ2021ZD0083

 2021byzd157

  • Received Date: 2023-11-08
    Available Online: 2024-05-29
    Abstract
  •   Objective  To investigate the application value of serum lipoprotein a (Lpa), plasma fibrinogen (FIB) and C-reactive protein (CRP) levels in the diagnosis of coronary heart disease (CHD).  Methods  Forty-three patients with CHD who received medical treatment in the First Affiliated Hospital of Bengbu Medical University from March 2020 to May 2021 were selected as the experimental group, and 45 healthy volunteers who received normal coronary angiography results in the same hospital during the same period were selected as the control group. Volunteers served as the control group. The clinical data of the two groups were compared. The plasma levels of Lpa, FIB and CRP were measured using the immunoturbidimetric method, coagulation method and immunoturbidimetric method, respectively, and a comparison of their levels was made between the CHD group and the control group. The optimal threshold for CHD diagnosis was determined by analyzing the individual diagnostic value of each indicator and the combined diagnostic value of the three through the ROC curve analysis.  Results  The levels of Lpa, FIB and CRP in the CHD group were higher than those in the control group (P < 0.05). The AUC of serum Lpa, FIB, and CRP for diagnosing CHD were 0.771 (95% CI: 0.674-0.868), 0.749 (95% CI: 0.640-0.859), and 0.791 (95% CI: 0.697-0.886), respectively, with sensitivities of 53.13%, 50.00%, 59.38% and specificities of 81.08%, 78.39%, 78.29%. The combined detection of the three to diagnose CHD area had an AUC of 0.884 (95% CI: 0.813-0.956), a sensitivity of 81.25%, and a specificity of 78.29%. The combined detection of serum Lpa, FIB, and CRP was better than individual detection.  Conclusion  The combined detection of Lpa, FIB and CRP can improve the sensitivity of CHD diagnosis and facilitate the early detection, thereby enabling proactive intervention to mitigate the development of the disease.

     

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