Volume 22 Issue 4
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CAO Jiang, ZHANG Yan, YUAN Nahua, ZHU Guidong. Effects of transcranial direct current stimulation on therapeutic effect and cognitive function in patients with depression[J]. Chinese Journal of General Practice, 2024, 22(4): 589-591. doi: 10.16766/j.cnki.issn.1674-4152.003457
Citation: CAO Jiang, ZHANG Yan, YUAN Nahua, ZHU Guidong. Effects of transcranial direct current stimulation on therapeutic effect and cognitive function in patients with depression[J]. Chinese Journal of General Practice, 2024, 22(4): 589-591. doi: 10.16766/j.cnki.issn.1674-4152.003457
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Effects of transcranial direct current stimulation on therapeutic effect and cognitive function in patients with depression

doi: 10.16766/j.cnki.issn.1674-4152.003457

  • The Sixth Ward of the Second People's Hospital of Lishui, Lishui, Zhejiang 323000, China

Funds:

 LGF22H090055

  • Received Date: 2023-12-27
    Available Online: 2024-05-29
    Abstract
  •   Objective  To investigate the therapeutic effect of transcranial direct current stimulation (tDCS) on patients with depression, and to observe its influence on the patients' cognitive function in order to provide a reference for the clinical application of tDCS in the treatment of depression.  Methods  A total of 112 patients with depression admitted to the Second People's Hospital of Lishui from March to December 2023 were selected as observation objects, and divided into control group (n=55) and tDCS group (n=57) according to whether they were treated with tDCS or not. The 17-item Hamilton depression scale (HAMD-17) score, Wisconsin card sorting test (WCST) score, and adverse reactions were compared between the two groups.  Results  After treatment, the overall efficacy rate of the tDCS group was higher than that of the control group [89.47% (51/57) vs. 69.09% (38/55), P < 0.01]. Before treatment, there was no significant difference in HAMD-17 score and WCST score between the two groups (P>0.05). After treatment, the HAMD-17 scores of both groups were significantly decreased (P < 0.05). After 4 weeks of treatment, the HAMD-17 score of the tDCS group was lower than that of the control group [(10.64±2.57) points vs. (15.82±2.96) points]. After 4 weeks of treatment, the 5-item WCST scores of the tDCS group were better than those of the control group (P < 0.001), and the patients' cognitive function was significantly improved. During treatment, adverse events occurred in both groups, including 1 case of nausea in the control group, 1 case of skin tingling, and 1 case of nausea in the tDCS group. There was no statistically significant difference in side effects between the two groups (P>0.05).  Conclusion  tDCS can effectively relieve the clinical symptoms of depression patients, the effect is obvious, and can improve the cognitive function of depression patients.

     

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