Volume 22 Issue 4
Apr.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(4): 592-596
DONG Zeying, YANG Qingqing, PAN Yan, CHEN Zhiping, LI Xin. Clinical effect of IVR+PRP combined with PPV on ocular surface function, refractive status and renal function in patients with proliferative diabetic retinopathy[J]. Chinese Journal of General Practice, 2024, 22(4): 592-596. doi: 10.16766/j.cnki.issn.1674-4152.003458
Citation: DONG Zeying, YANG Qingqing, PAN Yan, CHEN Zhiping, LI Xin. Clinical effect of IVR+PRP combined with PPV on ocular surface function, refractive status and renal function in patients with proliferative diabetic retinopathy[J]. Chinese Journal of General Practice, 2024, 22(4): 592-596. doi: 10.16766/j.cnki.issn.1674-4152.003458
shu

Clinical effect of IVR+PRP combined with PPV on ocular surface function, refractive status and renal function in patients with proliferative diabetic retinopathy

doi: 10.16766/j.cnki.issn.1674-4152.003458
  • 1.

    Department of Ophthalmology, the Second People's Hospital of Bengbu, Bengbu, Anhui 233000, China

Funds:

 2023AH051936

  • Received Date: 2023-11-08
    Available Online: 2024-05-29
    Abstract
  •   Objective  To observe the effects of pars plana vitrecto (PPV) assisted intravitreal ranibizumab (IVR) + pan-retinal photocoagulation (PRP) on ocular surface function, refractive status and renal function of patients with proliferative diabetic retinopathy (PDR), and to provide reference for the diagnosis and treatment of PDR.  Methods  A total of 103 patients with mild vitreous hemorrhage due to PDR were selected and divided into laser group (n=62) and combined group (n=41), according to their recorded treatment plans at Ophthalmology Department of the Second People's Hospital of Bengbu from April 2021 to June 2023. The laser group received IVR along with PRP, whlie the combined group underwent PPV in addition to the laser group. Before and after treatment, various parameters including tear film function [breakup time of tear film (BUT), Schirmer Ⅰ test (SIT), central corneal perception], VEGF level in fluid, central macular thickness (CMT), best corrected visual acuity (BCVA), refractive change, glycosylated hemoglobin (HbA1c), urinary microalbumin (mAlb) level and complications were detected and compared between the 2 groups.  Results  After 3 months of treatment, BUT and SIT values were increased in both groups, whlie CMT, BCVA, refractive change value, HbA1c level, and urinary mAlb level were decreased. Furthermore, BUT and central corneal perception in the combined group were higher than those in the laser group. On the other hand, CMT, BCVA, refractive status change, HbA1c level, and urinary mAlb level in the combined group were all significantly lower than those in the laser group (P < 0.05). After 7 days of treatment, VEGF level in aqueous fluid decreased in both groups. However, it was significantly lower in the combination group [(107.57±24.18) pg/mL] compared to that in the laser group [(184.38±30.25) pg/mL, t=14.325, P < 0.001]. The complication rate of the combination group was significantly lower than that of the laser group (P=0.041).  Conclusion  The additional PPV treatment, based on IVR+PRP, for PDR with mild vitreous hemorrhage does not impact the stability of ocular surface function. Moreover, it improves the visual acuity and refractive status in patients while alleviating edema and reducing the VEGF levels in aqueous humor. Furthermore, this treatment has minimal renal damage and low incidence of complications, making it highly suitable for clinical promotion and application.

     

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