Volume 22 Issue 4
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(4): 614-617
WANG Yao, HE Liting, CHEN Leyuan, PAN Jiahua, ZHANG Lan. Effect observation of compound sulfamethoxazole in the treatment of pertussis in children[J]. Chinese Journal of General Practice, 2024, 22(4): 614-617. doi: 10.16766/j.cnki.issn.1674-4152.003463
Citation: WANG Yao, HE Liting, CHEN Leyuan, PAN Jiahua, ZHANG Lan. Effect observation of compound sulfamethoxazole in the treatment of pertussis in children[J]. Chinese Journal of General Practice, 2024, 22(4): 614-617. doi: 10.16766/j.cnki.issn.1674-4152.003463
shu

Effect observation of compound sulfamethoxazole in the treatment of pertussis in children

doi: 10.16766/j.cnki.issn.1674-4152.003463

  • Department of Pediatrics, Anhui Provincial Hospital, Hefei, Anhui 230001, China

Funds:

 2021jyxm1760

  • Received Date: 2023-03-12
    Available Online: 2024-05-29
    Abstract
  •   Objective  To investigate the clinical efficacy and safety of compound sulfamethoxazole (SMZco) in treating pertussis in children.  Methods  A retrospective analysis was conducted on 124 children diagnosed with pertussis by polymerase chain reaction (PCR) at Anhui Provincial Hospital between June 2018 and January 2022. The children were divided into two groups: the SMZco group (59 cases) and macrolide group (65 cases). The total effective rate of treatment, duration of nocturnal cough, duration of spastic cough, duration of vomiting after coughing, duration of red face during coughing, duration of hospitalization, and incidence of drug side effects were compared between the two groups.  Results  Among the macrolide group, 23 cases (35.38%) showed a significant effect, 12 cases (18.46%) were effective, and 30 cases (46.15%) were invalid, resulting in a total effective rate of 53.85%; In the SMZco group, 35 cases(59.32%) were effective, 16 cases (27.12%) were significantly effective, and 8 cases (13.56%) were invalid, resulting in a total effective rate of 86.44%, the effective rate of SMZco group was significantly higher than that of macrolide group (P < 0.05). The hospital stay was 8.18 (6.00, 10.00) days in the SMZco group and 9.43 (7.00, 11.00) days in the macrolide group. The SMZco group had a statistically significant shorter hospital stay than the macrolide group (P < 0.05). Compared to the macrolide group, the duration of nocturnal coughing, spasmodic coughing, and the time of facial redness during cough were significantly shorter in the SMZco group, and the differences were statistically significant (P < 0.05). The vomiting time after cough was 1.31 (0.00, 3.00) days in the SMZco group and 1.92 (0.00, 4.00) days in the macrolide group, but the difference was not statistically significant (P>0.05).The incidence of adverse digestive reactions in the SMZco group was 6 cases (10.17%), which was lower than that in the macrolide group [16 cases (24.62%)], and the incidence of rash was 10 cases (16.95%), which was higher than that in the macrolide group [2 cases (3.08%)], and the differences were statistically significant (P < 0.05). The incidence of abnormal liver function in 9 cases (15.81%) in the SMZco group was lower than that in the macrolide group in 15 cases (25.40%), and the difference was not statistically significant (P>0.05).  Conclusion  SMZco can effectively treat whooping cough in children, and compared with macrolides in the treatment of whooping cough in children, it can significantly improve the overall effectiveness of treatment, shorten the duration of hospitalization and clinical symptoms, and reduce the incidence of adverse reactions. Therefore, the treatment of childhood pertussis with SMZco is of great significance and deserves the attention of pediatricians.

     

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    • References(21)
  • [1]
    VASCONEZ N S, JARAMILLO K, ZABALA A, et al. Bordetella pertussis, a reemerging pathogen in pediatric respiratory infections. A study in Quito, Ecuador[J]. Rev Argent Microbiol, 2021, 53(1): 27-33.
    [2]
    吴丹, 郑徽, 李明爽, 等. 中国2018—2021年百日咳流行病学特征[J]. 中国疫苗和免疫, 2022, 28(6): 638-643. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGJM202401007.htm

    WU D, ZHENG H, LI M S, et al. Epidemiological characteristics of pertussis in China from 2018 to 2021[J]. Chinese Journal of Vaccines and Immunization, 2022, 28(6): 638-643. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGJM202401007.htm
    [3]
    朱慧慧, 吕芳芳, 徐铭, 等. 儿童百日咳的临床特征研究及诊断标准探讨[J]. 四川大学学报(医学版), 2021, 52(5): 839-843. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYK202105022.htm

    ZHU H H, LYU F F, XU M, et al. Discussions on Clinical Characteristics and Diagnostic Criteria of Pertussis in Children[J]. Journal of Sichuan University(Medical Sciences), 2021, 52(5): 839-843. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYK202105022.htm
    [4]
    BERBERS G, VAN GAGELDONK P, KASSTEELE J V, et al. Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries[J]. Nat Commun, 2021, 12(1): 2871. DOI: 10.1038/s41467-021-23114-y.
    [5]
    王静娟, 庞琳, 米荣, 等. 儿童百日咳临床特征及重症百日咳危险因素分析[J]. 中国实用儿科杂志, 2021, 36(12): 941-946. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK202112014.htm

    WANG J J, PANG L, MI R, et al. Clinical characteristics of pertussis in children and risk factors for severe pertussis[J]. Chinese Journal of Practical Pediatrics, 2021, 36(12): 941-946. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK202112014.htm
    [6]
    俞栋, 邵晓丽. 儿童疫苗接种和热性惊厥相关性研究进展[J]. 中华全科医学, 2022, 20(11): 1930-1933. doi: 10.16766/j.cnki.issn.1674-4152.002738

    YU D, SHAO X L. Research progress on the correlation between childhood vaccination and febrile convulsion[J]. Chinese Journal of General Practice, 2022, 20(11): 1930-1933. doi: 10.16766/j.cnki.issn.1674-4152.002738
    [7]
    MERDRIGNAC L, AIT E B F, PANDOLFI E, et al. Incidence and severity of pertussis hospitalisations in infants aged less than 1 year in 37 hospitals of six EU/EEA countries, results of pertinent sentinel pilot surveillance system, December 2015 to December 2018[J]. Euro Surveill, 2021, 26(4): 1900762. DOI: 10.2807/1560-7917.ES.2021.26.4.1900762.
    [8]
    RANE M S, ROHANI P, HALLORAN M E. Association of diphtheria-tetanus-acellular pertussis vaccine timeliness and number of doses with age-specific pertussis risk in infants and young children[J]. Jama Netw Open, 2021, 4(8): e2119118. DOI: 10.1001/jamanetworkopen.2021.19118.
    [9]
    徐周. 儿童百日咳临床流行特征及其密切接触者感染现况[D]. 沈阳: 中国医科大学, 2021.

    XU Z. Clinical epidemiological characteristics of pertussis in children and the infection status of close contacts[D]. Shenyang: China Medical University, 2021.
    [10]
    CIMOLAI N. Pharmacotherapy for bordetella pertussis infection. Ⅱ. A synthesis of clinical sciences[J]. Int J Antimicrob Agents, 2021, 57(3): 106257. DOI: 10.1016/j.ijantimicag.2020.106257.
    [11]
    张春燕, 马玉洁. 甲泼尼龙琥珀酸钠联合红霉素治疗百日咳患儿的效果[J]. 临床医学, 2023, 43(5): 109-111. https://www.cnki.com.cn/Article/CJFDTOTAL-EBED202305035.htm

    ZHANG C Y, MA Y J. Efficacy of methylprednisolone sodium succinate combined with erythromycin in the treatment of children with pertussis[J]. Clinical Medicine, 2023, 43(5): 109-111. https://www.cnki.com.cn/Article/CJFDTOTAL-EBED202305035.htm
    [12]
    袁巧云. 注射用甲泼尼龙琥珀酸钠联合阿奇霉素对儿童支原体大叶性肺炎症状改善及血清炎性因子水平的影响[J]. 中国药物与临床, 2021, 21(24): 4041-4043. https://www.cnki.com.cn/Article/CJFDTOTAL-YWLC202124040.htm

    YUAN Q Y. Effects of methylprednisolone sodium succinate for injection combined with azithromycin on symptom improvement and serum inflammatory cytokine levels in children with mycoplasma pneumonia[J]. Chinese Remedies & Clinics, 2021, 21(24): 4041-4043. https://www.cnki.com.cn/Article/CJFDTOTAL-YWLC202124040.htm
    [13]
    HUA C Z, WANG H J, ZHANG Z, et al. In vitro activity and clinical efficacy of macrolides, cefoperazone-sulbactam and piperacillin/piperacillin-tazobactam against Bordetella pertussis and the clinical manifestations in pertussis patients due to these isolates: a single-centre study in Zhejiang Province, China[J]. J Glob Antimicrob Resist, 2019, 18: 47-51. doi: 10.1016/j.jgar.2019.01.029
    [14]
    LEWIS S, ERICKSON B. Erythromycin-resistant bordetella pertussis: Yuma County, Arizona, May-October 1994[J]. Morb Mortal Wkly Rep, 1994, 43(44): 807-810.
    [15]
    KOIDE K, YAO S M, CHIANG C S, et al. Genotyping and macrolide-resistant mutation of bordetella pertussis in East and South-East Asia[J]. J Glob Antimicrob Resist, 2022, 31: 263-269. doi: 10.1016/j.jgar.2022.10.007
    [16]
    雷炎玲, 王红梅, 张交生, 等. 百日咳患儿及密切接触者的细菌培养和药物敏感性检测[J]. 儿科药学杂志, 2021, 27(4): 37-39. https://www.cnki.com.cn/Article/CJFDTOTAL-EKYX202104012.htm

    LEI Y L, WANG H M, ZHANG J S, et al. Bacterial Culture and Drug Sensitivity Detection in Children with Pertussis and Close Contacts[J]. Journal of Pediatric Pharmacy, 2021, 27(4): 37-39. https://www.cnki.com.cn/Article/CJFDTOTAL-EKYX202104012.htm
    [17]
    MI Y M, HUA C Z, FANG C, et al. Effect of macrolides and β-lactams on clearance of bordetella pertussis in the nasopharynx in children with whooping cough[J]. Pediatr Infect Dis J, 2021, 40(2): 87-90. doi: 10.1097/INF.0000000000002911
    [18]
    张娟胜, 张弟强, 林晨, 等. 西安市与上海市百日咳鲍特菌对大环内酯类抗生素的耐药性、耐药相关分子特征及多位点抗原序列分型的比较研究[J]. 西安交通大学学报(医学版), 2022, 43(5): 691-696. https://www.cnki.com.cn/Article/CJFDTOTAL-XAYX202205011.htm

    ZHANG J S, ZHANG D Q, LIN C, et al. Comparison of macrolide resistance, molecular characteristics and MAST types of Bordetella pertussis collected from Xi'an and Shanghai[J]. Journal of Xi'an Jiaotong University(Medical Sciences), 2022, 43(5): 691-696. https://www.cnki.com.cn/Article/CJFDTOTAL-XAYX202205011.htm
    [19]
    LIN X J, ZOU J, YAO K, et al. Analysis of antibiotic sensitivity and resistance genes of bordetella pertussis in Chinese children[J]. Medicine, 2021, 100(2): e24090. DOI: 10.1097/MD.0000000000024090.
    [20]
    雷炎玲, 王红梅, 张交生, 等. 百日咳患儿及密切接触者的细菌培养和药物敏感性检测[J]. 儿科药学杂志, 2021, 27(4): 37-39. https://www.cnki.com.cn/Article/CJFDTOTAL-EKYX202104012.htm

    LEI Y L, WANG H M, ZHANG J S, et al. Bacterial Culture and Drug Sensitivity Detection in Children with Pertussis and Close Contacts[J]. Journal of Pediatric Pharmacy, 2021, 27(4): 37-39. https://www.cnki.com.cn/Article/CJFDTOTAL-EKYX202104012.htm
    [21]
    中华医学会儿科学分会临床药理学组, 《中华儿科杂志》编辑委员会. 中国儿科超说明书用药专家共识[J]. 中华儿科杂志, 2016, 54(2): 101-103. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYS202211002.htm

    Clinical Pharmacology Group, Pediatrics Branch of Chinese Medical Association, Editorial Board of Chinese Journal of Pediatrics. Expert consensus on off-label medication in pediatrics in China[J]. Chinese Journal of Pediatrics, 2016, 54(2): 101-103. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYS202211002.htm
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