Volume 22 Issue 4
Apr.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(4): 618-621
ZHANG Shuhong, LING Yingchun, LUO Fang, SHENG Gaoyang. Observation on the therapeutic effect of combined butylphthalide and repeated transcranial magnetic stimulation on mild cognitive impairment after cerebral infarction[J]. Chinese Journal of General Practice, 2024, 22(4): 618-621. doi: 10.16766/j.cnki.issn.1674-4152.003464
Citation: ZHANG Shuhong, LING Yingchun, LUO Fang, SHENG Gaoyang. Observation on the therapeutic effect of combined butylphthalide and repeated transcranial magnetic stimulation on mild cognitive impairment after cerebral infarction[J]. Chinese Journal of General Practice, 2024, 22(4): 618-621. doi: 10.16766/j.cnki.issn.1674-4152.003464
shu

Observation on the therapeutic effect of combined butylphthalide and repeated transcranial magnetic stimulation on mild cognitive impairment after cerebral infarction

doi: 10.16766/j.cnki.issn.1674-4152.003464
  • 1.

    Department of Neurology, Longyou People' s Hospital, Quzhou, Zhejiang 324400, China

Funds:

 2022KY1309

  • Received Date: 2024-01-03
    Available Online: 2024-05-29
    Abstract
  •   Objective  This study aims to explore the efficacy and safety of combing butylphthalide with repetitive transcranial magnetic stimulation for treating mild cognitive impairment in patients following cerebral infarction, offering valuable insights for clinical treatment.  Methods  A total of 190 patients with mild cognitive impairment after cerebral infarction were randomly divided into either Group A (n=95) or Group B (n=95) at Longyou People' s Hospital from February 2020 to January 2023. Group A received butylphthalide treatment, while Group B received a combination of butylphthalide and repetitive transcranial magnetic stimulation. The study aimed to compare the treatment effects, cognitive function, cerebral blood flow indicators, inflammatory reactions indicators, and adverse reactions between the two groups.  Results  The total effective rate of treatment in Group B (90.53%, 86/95) was significantly higher than in Group A (71.58%, 68/95, P < 0.05). Both groups demonstrated improved cognitive function compared to before treatment, with Group B showing a significantly higher Montreal cognitive assessment (MoCA) score than Group A [(26.33±2.50) points vs. (24.21±2.84) points, P < 0.05]; After treatment, both groups exhibited decreased pulsatile index of blood flow in both groups of patients decreased, and the systolic and average blood flow velocities of blood flow and increased systolic and average blood flow velocities (P < 0.05). However, Group B showed better cerebral blood flow indicators compared to Group A (P < 0.05). Post-treatment C-reactive protein, tumor necrosis factor-α, and interleukin-1β decreased in both groups (P < 0.05), with all indicators in Group B being lower than in Group A (P < 0.05). There were no significant differences in adverse reactions between the two groups (P>0.05).  Conclusion  The combination of butylphthalide and repetitive transcranial magnetic stimulation demonstrates a significant therapeutic effect on mild cognitive impairment following cerebral infarction. It effectively improves cognitive function, enhances cerebral blood flow indicators, reduces inflammatory reactions, and exhibits minimal adverse reactions. This treatment approach is both effective and safe, warranting its promotion.

     

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