Volume 22 Issue 4
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TAN Chenlei, LI Yanhua. The role of adipocytokines in ovarian senescence[J]. Chinese Journal of General Practice, 2024, 22(4): 661-664. doi: 10.16766/j.cnki.issn.1674-4152.003474
Citation: TAN Chenlei, LI Yanhua. The role of adipocytokines in ovarian senescence[J]. Chinese Journal of General Practice, 2024, 22(4): 661-664. doi: 10.16766/j.cnki.issn.1674-4152.003474
shu

The role of adipocytokines in ovarian senescence

doi: 10.16766/j.cnki.issn.1674-4152.003474
  • 1.

    The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China

  • Received Date: 2023-11-29
    Available Online: 2024-05-29
    Abstract
  • Ovarian senescence is characterized by a decline in the number and quality of oocytes or follicular pools, causing a decline in fertility. With the continuous development of social and economic levels and the promulgation of China ' s three-child policy, there is a growing tension between the ever-delayed reproductive age and the ever-declining follicular pool. Declining fertility at an advanced age is also a serious challenge. How to delay ovarian senescence and meet the reproductive needs of women of childbearing age has become a focus of medical researchers in recent years. At present, common adipocytokines are biologically active molecules mainly produced by adipocytes. They are involved in a variety of physiological processes such as energy metabolism and internal and external environment balance of the body and may be involved in the occurrence of a series of obesity-related diseases such as diabetes and atherosclerosis. In the female reproductive system, some common adipocytokines, such as leptin, visfatin, adiponectin, chemokine, and adipoinflammatory factors, regulate follicle quality and growth and development through endocrine, paracrine, and autocrine pathways. Leptin has been found to promote follicle maturation within a certain range of concentrations, and either too high or too low concentrations may cause adverse effects on oocytes. Visfatin has been reported to stimulate ovarian angiogenesis, thereby enhancing fertility. Adiponectin can regulate the metabolism and apoptosis of granulosa cells and cumulus cells through related pathways, thereby protecting follicle development. Chemerin inhibits granulosa cell proliferation, induces apoptosis, and inhibits follicle-stimulating hormone-induced production of estradiol and progesterone by granulosa cells. Inflammation caused by adipocytokines may be one of the mechanisms involved in the age-related regulation of follicle number. Through reviewing relevant literature, this paper attempts to explore the role of common adipocytokines in ovarian aging, to provide some theoretical references for general practitioners in the health care of women of reproductive age.

     

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