Volume 22 Issue 5
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DENG Tianyu, WANG Xiaoyan. The role of GSDME-dependent pyroptosis in renal diseases[J]. Chinese Journal of General Practice, 2024, 22(5): 845-849. doi: 10.16766/j.cnki.issn.1674-4152.003517
Citation: DENG Tianyu, WANG Xiaoyan. The role of GSDME-dependent pyroptosis in renal diseases[J]. Chinese Journal of General Practice, 2024, 22(5): 845-849. doi: 10.16766/j.cnki.issn.1674-4152.003517
shu

The role of GSDME-dependent pyroptosis in renal diseases

doi: 10.16766/j.cnki.issn.1674-4152.003517
  • 1.

    Department of Nephrology, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu 210019, China

Funds:

 81970605

  • Received Date: 2023-11-09
    Available Online: 2024-07-20
    Abstract
  • Pyroptosis is a newly discovered form of programmed cell death that relies on caspase-1 and inflammasome activation to initiate the cell death process. This pathway is characterized by compromised membrane integrity and the release of numerous pro-inflammatory factors. Gasdermin E (GSDME), a member of the gasdermin family, plays a pivotal role in pyroptosis induction. It is widely expressed in normal tissues and can convert apoptosis into pyroptosis. Kidney diseases pose significant health risks to humans. In recent years, researchers have gradually revealed and confirmed the involvement of GSDME-dependent pyroptosis in the pathogenesis of kidney diseases. A comprehensive understanding of the role of GSDME-dependent pyroptosis in renal disease will facilitate the identification of novel targets for diagnosing and treatment. To provide valuable references for clinical and basic researchers, we present a review and summary of studies investigating the association between GSDME-dependent pyroptosis and renal diseases, including acute kidney injuries, diabetic nephropathy, renal carcinoma, obstructive nephropathy, and lupus glomerulonephritis.

     

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