Volume 22 Issue 5
May  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(5): 900-902
JING Zhaohe, WANG Yingjie, MAI Yumiao, SUN Pan, DONG Pengpeng, LIU Jian. Acquired hemophilia following haploidentical hematopoietic stem cell transplantation for acute lymphoblastic leukemia in children: one case report and literature review[J]. Chinese Journal of General Practice, 2024, 22(5): 900-902. doi: 10.16766/j.cnki.issn.1674-4152.003530
Citation: JING Zhaohe, WANG Yingjie, MAI Yumiao, SUN Pan, DONG Pengpeng, LIU Jian. Acquired hemophilia following haploidentical hematopoietic stem cell transplantation for acute lymphoblastic leukemia in children: one case report and literature review[J]. Chinese Journal of General Practice, 2024, 22(5): 900-902. doi: 10.16766/j.cnki.issn.1674-4152.003530
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Acquired hemophilia following haploidentical hematopoietic stem cell transplantation for acute lymphoblastic leukemia in children: one case report and literature review

doi: 10.16766/j.cnki.issn.1674-4152.003530

  • Department of Pediatrics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China

Funds:

 JC21854036

  • Received Date: 2023-04-19
    Available Online: 2024-07-20
    Abstract
  • Acquired hemophilia (AH) is a rare disease caused by autoantibodies against factors. We reported a case of acute lymphoblastic leukemia (T-lineage, high-risk) in a child who developed acquired hemophilia after haploidentical hematopoietic stem cell transplantation (paternal donor, HLA 5/10) and reviewed the relevant literature. Laboratory tests showed decreased coagulation factor Ⅸ activity (FⅨ: C), FⅪ: C, and FⅫ: C, and an elevated FⅨ inhibitor titer, which is rare the clinic. After diagnosis, the child was treated with methylprednisolone in combination with cyclosporine A. With improvement of symptoms, the patient was discharged and continued to take cyclosporine A and methylprednisolone regularly. Four months after discharge, symptoms recurred, and the treatment regimen was changed to double-dose methylprednisolone combined with cyclosporine A immunosuppressive therapy, and the child was discharged with improvement. There was no recurrence of symptoms until March 2023.

     

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