Volume 22 Issue 6
Jun.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(6): 947-950
YANG Bo, ZHANG Qingsong, WANG Beibei, NI Fangfang, ZHANG Ying, HAN Shuqi. The prognostic value of lymph node ratio in 89 patients with stage ⅢC1p cervical cancer who underwent surgery[J]. Chinese Journal of General Practice, 2024, 22(6): 947-950. doi: 10.16766/j.cnki.issn.1674-4152.003541
Citation: YANG Bo, ZHANG Qingsong, WANG Beibei, NI Fangfang, ZHANG Ying, HAN Shuqi. The prognostic value of lymph node ratio in 89 patients with stage ⅢC1p cervical cancer who underwent surgery[J]. Chinese Journal of General Practice, 2024, 22(6): 947-950. doi: 10.16766/j.cnki.issn.1674-4152.003541
shu

The prognostic value of lymph node ratio in 89 patients with stage ⅢC1p cervical cancer who underwent surgery

doi: 10.16766/j.cnki.issn.1674-4152.003541

  • Department of Gynecology and oncology, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 2023AH051982

  • Received Date: 2024-03-06
    Available Online: 2024-07-22
    Abstract
  •   Objective  To investigate the prognostic impact of lymph node ratio (LNR) on 2018 International Federation of Gynaecology and Obstetrics Stage ⅢC1p cervical cancer patients.  Methods  A total of 89 patients with lymph node-positive cervical cancer from January 2014 to December 2017 in the Oncology Department of the First Affiliated Hospital Bengbu Medical University underwent radical hysterectomy and systematic pelvic lymphadenectomy with or without abdominal aortic dissection. All patients received concurrent chemoradiotherapy. LNR was defined as the ratio of positive lymph nodes to the total number of LNS removed. Patients were divided into 2 groups according to LNR; LNR < 0.06(42 cases) and LNR≥0.06 (47 cases). The prognostic value of LNR was assessed by univariate log-rank test and multivariable Cox regression models.  Results  The median follow-up was 44.6 months (range, 6-115 months), and the 5-year disease-free survival (DFS) rate for the entire cohort was 61.6%, while the 5-year overall survival (OS) rate was 69.7%. The 5-year DFS rates for LNR < 0.06 and LNR≥0.06 were 65.4% and 54.2%, respectively (P=0.027). Furthermore, the 5-year OS rates for LNR < 0.06 and LNR≥0.06 were 82.8% and 59.6%, respectively (P=0.003). In multivariable analysis, LNR≥0.06 was associated with worse DFS (HR=2.040, 95% CI: 1.130-3.870, P=0.013) and OS (HR=1.940, 95% CI: 1.020-3.780, P=0.038).  Conclusion  LNR≥0.06 may be an independent prognostic factor for decreased DFS and OS in patients with stage ⅢC1P cervical cancer.

     

    • FullText(HTML)
  • loading
    • References(17)
  • [1]
    WANG M T, MA M, YANG L J, et al. Development and validation of a nomogram for predicting pelvic lymph node metastasis and prognosis in patients with cervical cancer[J]. Front Oncol, 2022, 12: 952347. DOI: 10.3389/fonc.2022.952347.
    [2]
    ASLAN K, MEYDANLI M M, OZ M, et al. The prognostic value of lymph node ratio in stage ⅢC cervical cancer patients triaged to primary treatment by radical hysterectomy with systematic pelvic and para-aortic lymphadenectomy[J]. J Gynecol Oncol, 2020, 31(1): e1. DOI: 10.3802/jgo.2020.31.e1.
    [3]
    WIDSCHWENDTER P, POLASIK A, JANNI W, et al. Lymph node ratio can better predict prognosis than absolute number of positive lymph nodes in operable cervical carcinoma[J]. Oncol Res Treat, 2020, 43(3): 87-95. doi: 10.1159/000505032
    [4]
    龙行涛, 周琦, 王冬, 等. 子宫颈癌2018年FIGO新分期ⅢC期患者预后分析[J]. 中国癌症杂志, 2021, 31(8): 725-733. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGAZ202108005.htm

    LONG X T, ZHOU Q, WANG D, et al. The prognostic value of revised 2018 FIGO stageⅢC in cervical cancer[J]. China Oncology, 2021, 31(8): 725-733. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGAZ202108005.htm
    [5]
    RYU J M, CHOI Y S, BAE J Y. Prognostic factors in women with cervical cancer stage ⅢC1r treated with concurrent chemoradiotherapy[J]. J Obstet Gynaecol Res, 2020, 46(7): 1165-1172. doi: 10.1111/jog.14305
    [6]
    FEMANDES A, VIVEROS-CARREÑO D, HOEGL J, et al. Human papillomavirus-independent cervical cancer[J]. Int J Gynecol Cancer, 2022, 32(1): 1-7. doi: 10.1136/ijgc-2021-003014
    [7]
    XU J, MA Y L, MEI H B, et al. Diagnostic value of multimodal magnetic resonance imaging in discriminating between metastatic and non-metastatic pelvic lymph nodes in cervical cancer[J]. Int J Gen Med, 2022, 15: 6279-6288. doi: 10.2147/IJGM.S372154
    [8]
    TOHYAMA A, MURAKAMI M, YOSHINO K. Strategies for the treatment of cervical cancer with bulky pelvic lymph nodes: an overview of the current evidence[J]. J UOEH, 2020, 42(4): 317-325. doi: 10.7888/juoeh.42.317
    [9]
    张慧慧, 王蓓蓓, 张献文, 等. 伴有盆腔淋巴结转移的宫颈癌新辅助化疗联合放化疗临床疗效及预后因素分析[J]. 中华全科医学, 2021, 19(11): 1823-1826, 1839. doi: 10.16766/j.cnki.issn.1674-4152.002176

    ZHANG H H, WANG B B, ZHANG X W, et al. Treatment effect and analysis of prognostic factors of neoadjuvant chemotherapy followed by concurrent chemoradiotherapy for advanced cervical cancer with pelvic lymph node metastasis[J]. Chinese Journal of General Practice, 2021, 19(11): 1823-1826, 1839. doi: 10.16766/j.cnki.issn.1674-4152.002176
    [10]
    OLTHOF E P, MOM C H, SNIJDERS M L H, et al. The prognostic value of the number of positive lymph nodes and the lymph node ratio in early-stage cervical cancer[J]. Acta Obstet Gynecol Scand, 2022, 101(5): 550-557. doi: 10.1111/aogs.14316
    [11]
    JIN C, LI J, ZOU C X, et al. Lymph node ratio predicts prognosis in patients with surgically resected invasive pancreatic cystic neoplasms[J]. Transl Cancer Res, 2020, 9(10): 5843-5856. doi: 10.21037/tcr-20-1355
    [12]
    SUPSAMUTCHAI C, WILASRUSMEE C, JIRASIRITHAM J, et al. Recurrence outcome of lymph node ratio in gastric cancer after underwent curative resection: a retrospective cohort study[J]. Ann Med Surg (Lond), 2020, 54: 57-61. doi: 10.1016/j.amsu.2020.04.002
    [13]
    SAKIN A, ALDEMTR M N. Lymph node ratio predicts long-term survival in lymph node-positive breast cancer[J]. Eur J Breast Health, 2020, 16(4): 270-275. doi: 10.5152/ejbh.2020.5809
    [14]
    余淼, 冉立, 常建英, 等. 淋巴结转移和淋巴结阳性比率对早期宫颈癌预后的影响分析[J]. 中国临床医生杂志, 2020, 48(6): 733-736. doi: 10.3969/j.issn.2095-8552.2020.06.033

    YU M, RAN L, CHANG J Y, et al. Analysis of the influence of lymph node metastasis and lymph node positive ratio on prognosis of early cervical cancer[J]. Chinese Journal For Clinicians, 2020, 48(6): 733-736. doi: 10.3969/j.issn.2095-8552.2020.06.033
    [15]
    KIM S I, KIM T H, LEE M, et al. Lymph node ratio is a strong prognostic factor in patients with early-stage cervical cancer undergoing minimally invasive radical hysterectomy[J]. Yonsei Med J, 2021, 62(3): 231-239. doi: 10.3349/ymj.2021.62.3.231
    [16]
    BOGANI G, VINTI D, MuRGIA F, et al. Burden of lymphatic disease predicts efficacy of adjuvant radiation and chemotherapy in FIGO 2018 stage ⅢCp cervical cancer[J]. Int J Gynecol Cancer, 2019, 29(9): 1355-1360. doi: 10.1136/ijgc-2019-000669
    [17]
    FAN X, WANG Y F, YANG N, et al. Prognostic analysis of patients with stage ⅢC1p cervical cancer treated by surgery[J]. World J Surg Oncol, 2023, 21(1): 186. doi: 10.1186/s12957-023-03076-9
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(2)  / Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (181) PDF downloads(8) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return