Volume 22 Issue 6
Jun.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(6): 962-965
SHI Jingjing, BAO Jieyu, ZHANG Jing, CAI Mengmeng, CHAO Linlin, ZHAO Jianhua. Effect of atherosclerotic plaque characteristics of middle cerebral artery on cerebral infarction caused by arterial stenosis[J]. Chinese Journal of General Practice, 2024, 22(6): 962-965. doi: 10.16766/j.cnki.issn.1674-4152.003544
Citation: SHI Jingjing, BAO Jieyu, ZHANG Jing, CAI Mengmeng, CHAO Linlin, ZHAO Jianhua. Effect of atherosclerotic plaque characteristics of middle cerebral artery on cerebral infarction caused by arterial stenosis[J]. Chinese Journal of General Practice, 2024, 22(6): 962-965. doi: 10.16766/j.cnki.issn.1674-4152.003544
shu

Effect of atherosclerotic plaque characteristics of middle cerebral artery on cerebral infarction caused by arterial stenosis

doi: 10.16766/j.cnki.issn.1674-4152.003544

  • Department of Neurology, People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Zhengzhou, Henan 450003, China

Funds:

 SBGJ202102034

  • Received Date: 2023-05-20
    Available Online: 2024-07-22
    Abstract
  •   Objective  To explore the correlation between vessel wall characteristics and infarction patterns in patients with atherosclerotic stenosis of the middle cerebral artery (MCA) using high-resolution magnetic resonance vessel wall imaging (HRMR-VWI) and diffusion-weighted imaging (DWI).  Methods  A retrospective study was conducted at the People's Hospital of Zhengzhou University from January 2021 to December 2022, involving 68 patients with acute ischemic stroke in the MCA due to atherosclerotic stenosis. Patients were categorized into single-and multiple-infarct groups based on DWI findings, and various atherosclerosis risk factors, degree of lumen stenosis, and plaque characteristics were compared between the two groups. Logistic regression analysis was performed to assess the relationship between vessel wall properties and infarct patterns in MCA atherosclerotic stenosis patients.  Results  Among 68 patients with atherosclerotic stenosis in the middle cerebral artery, 45 patients (66.18%) had multiple infarcts, and 23 (33.82%) had single infarcts. There were no significant difference in age, sex, hypertension, diabetes, hyperlipidemia, smoking history, cardiovascular disease history, cerebrovascular disease history and NIHSS score between the two groups (P>0.05). Degree of stenosis and prevalence of intraplaque hemorrhage (IPH) were significantly greater in the multiple-infarction group than those in the single-infarction group (degree of stenosis: P=0.029; IPH: P=0.025). There was no significant difference in eccentricity and plaque enhancement between the two groups (P>0.05). After adjusting for age, sex, hypertension, diabetes, hyperlipidemia, smoking history, cardiovascular disease history, cerebrovascular disease history, NIHSS score and other confounding factors, logistic regression analysis showed that IPH (adjusted OR=6.525, 95% CI: 1.108-38.442, P= 0.038) was independent predictor for multiple infarction.  Conclusion  IPH is independently associated with multiple infarcts. HRMR-VWI may provide new insight into the mechanisms underlying the different MCA infarction patterns.

     

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