Analysis of curative effect of <i>Zishen Huoxue</i> Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve

SUN Shuyun; YIN Yihong; YE Liqun

doi:10.16766/j.cnki.issn.1674-4152.003547

Volume 22 Issue 6

Jun. 2024

Turn off MathJax

Article Contents

Article Navigation > Chinese Journal of General Practice > 2024 > 22(6): 975-978

SUN Shuyun, YIN Yihong, YE Liqun. Analysis of curative effect of Zishen Huoxue Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve[J]. Chinese Journal of General Practice, 2024, 22(6): 975-978. doi: 10.16766/j.cnki.issn.1674-4152.003547

Citation:

SUN Shuyun, YIN Yihong, YE Liqun. Analysis of curative effect of Zishen Huoxue Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve[J]. Chinese Journal of General Practice, 2024, 22(6): 975-978. doi: 10.16766/j.cnki.issn.1674-4152.003547

Citation:

PDF( 492 KB)

Analysis of curative effect of Zishen Huoxue Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve

doi: 10.16766/j.cnki.issn.1674-4152.003547

Department II of Gynecology, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, Zhejiang 315010, China

Funds:

GZY-ZJ-KJ-23090

2022J285

Received Date: 2023-11-16
Available Online: 2024-07-22

Abstract

Abstract

Objective To observe and analyze the clinical efficacy of Zishen Huoxue Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve, and its effect on ovarian function and ovarian blood flow, providing a basis for clinical treatment. Methods A total of 750 patients with diminished ovarian reserve (kidney deficiency and blood stasis type) admitted to Ningbo Municipal Hospital of Traditional Chinese Medicine(TCM) from July 2022 to November 2023 were selected as the study subjects, and the included patients were divided into group A (treated with Zishen Huoxue Decoction), group B (treated with estradiol valerate tablets combined with dydrogesterone tablets), and group C (treated with Zishen Huoxue Decoction + estradiol valerate tablets combined with dydrogesterone tablets) using the random number table method, with 250 patients in each group. Treatment effects, changes in follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Müllerian hormone (AMH), antral follicle count (AFC), ovarian volume (OV), and ovarian stromal flow index before and after treatment were compared among the three groups of patients. Results The total effective rates of group A, group B, and group C were 82.0% (205/250), 64.4% (161/250), and 90.8% (227/250), respectively, and the total effective rates of group C were all higher than those of group B and A, and the total effective rate of group A was higher than that of group B (P < 0.05). After treatment, FSH and LH decreased more significantly in group C than in groups A and B, and FSH and LH decreased more significantly in group A than in group B (P < 0.05). AMH rose more significantly in group C than in groups A and B, and AMH rose more significantly in group A than in group B (P < 0.05). AFC and OV rose more significantly in group C than in groups A and B after treatment, and AFC and OV rose more significantly in group A than in group B (P < 0.05). PSV, VI, and FI rose were more significantly in group C than in groups A and B after treatment, and VI levels rose was more significantly in group A than in group B (P < 0.05). Conclusion Zishen Huoxue Decoction can effectively regulate ovarian function and improve ovarian blood supply in patients with kidney deficiency and blood stasis type of diminished ovarian reserve, with remarkable clinical efficacy, and is worth applying in clinical practice.
- Diminished ovarian reserve,
- Kidney deficiency and blood stasis type,
- Zishen Huoxue Decoction,
- Ovarian blood flow

FullText(HTML)

References(30)

References

[1]	YIN J, CHANG H M, LI R, et al. Recent progress in the treatment of women with diminished ovarian reserve[J]. GOCM, 2021, 1(4): 186-189. doi: 10.1016/j.gocm.2021.10.004
[2]	梁秀茹, 孟艳. 卵巢储备功能减退的内质网应激机制及其研究进展[J]. 中华生殖与避孕杂志, 2020, 40(6): 521-525. doi: 10.3760/cma.j.cn101441-20190601-00233 LIANG X R, MENG Y. Research progress of endoplasmic reticulum stress on diminished ovarian reserve[J]. Chinese Journal of Reproduction and Contraception, 2020, 40(6): 521-525. doi: 10.3760/cma.j.cn101441-20190601-00233
[3]	JIAO Z, BUKULMEZ O. Potential roles of experimental reproductive technologies in infertile women with diminished ovarian reserve[J]. J Assist Reprod Genet, 2021, 38(10): 2507-2517. doi: 10.1007/s10815-021-02246-6
[4]	刘阿慧, 张学红. 卵巢储备功能降低女性的生育策略研究新进展[J]. 中国计划生育和妇产科, 2022, 14 (6): 10-13. doi: 10.3969/j.issn.1674-4020.2022.06.03 LIU A H, ZHANG X H. New advances in fertility strategies for women with reduced ovarian reserve[J]. Chinese Journal of Family Planning & Gynecotokology, 2022, 14 (6): 10-13. doi: 10.3969/j.issn.1674-4020.2022.06.03
[5]	BOMPOULA M S, VALSAMAKIS G, NEOFYTOU S, et al. Demographic, clinical and hormonal characteristics of patients with premature ovarian insufficiency and those of early menopause: data from two tertiary premature ovarian insufficiency centers in Greece[J]. Gynecol Endocrinol, 2020, 36(8): 693-697. doi: 10.1080/09513590.2020.1739266
[6]	杨思晨, 王玲, 章勤, 等. 中医药治疗卵巢功能减退性疾病研究文献可视化分析[J]. 中国中医药信息杂志, 2023, 30(4): 34-40. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY202304006.htm YANG S C, WANG L, ZHANG Q, et al. Literature visual analysis of TCM research on ovarian hypofunction diseases[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2023, 30(4): 34-40. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY202304006.htm
[7]	谢幸, 孔北华, 段涛. 妇产科学[M]. 9版. 北京: 人民卫生出版社, 2018: 359. XIE X, KONG B H, DUAN T. Gynecology and obstetrics[M]. 9th edition. Beijing: People's Medical Publishing House, 2018: 359.
[8]	卵巢储备功能减退临床诊治专家共识专家组, 中华预防医学会生育力保护分会生殖内分泌生育保护学组. 卵巢储备功能减退临床诊治专家共识[J]. 生殖医学杂志, 2022, 31(4): 425-434. doi: 10.3969/j.issn.1004-3845.2022.04.001 Consensus expert group on clinical diagnosis and treatment of ovarian reserve dysfunction, Reproductive endocrinology and Fertility Protection Group, Fertility Protection Branch, Chinese Preventive Medical Association. Consensus on clinical diagnosis and management of diminished ovarian reserve[J]. Journal of Reproductive Medicine, 2022, 31(4): 425-434. doi: 10.3969/j.issn.1004-3845.2022.04.001
[9]	李灿东, 吴承玉. 中医诊断学[M]. 10版. 北京: 中国中医药出版社, 2012: 91-93. LI C D, WU C Y, (Ed.). TCM diagnostics[M]. 10th edition. Beijing: China Traditional Chinese Medicine Press, 2012: 91-93.
[10]	谈勇. 中医妇科学[M]. 10版. 北京: 中国中医药出版社, 2016: 139-141. Tan Y. Gynecology of traditional Chinese medicine[M]. 10th edition. Beijing: China Traditional Chinese Medicine Press, 2016: 139-141.
[11]	郑筱萸. 中药新药临床研究指导原则试行[M]. 北京: 中国医药科技出版社, 2002: 239-243. ZHENG X Y. Trial implementation of guiding principles for clinical research of new Chinese medicine[M]. Beijing: China Medical Science Press, 2002: 239-243.
[12]	SCANTAMBURLO V M, VON LINSINGEN R, CENTA L J R, et al. Association between decreased ovarian reserve and poor oocyte quality[J]. Obstetrics & Gynecology Science, 2021, 64(6): 532-539.
[13]	BARROS F, CARVALHO F, BARROS A, et al. Premature ovarian insufficiency: clinical orientations for genetic testing and genetic counseling[J]. Porto Biomed, 5(3): e62. DOI: 10.1097/j.pbj.0000000000000062.
[14]	田沛哲, 李蕾, 范英英, 等. 卵巢储备功能减退的研究进展[J]. 中华实用诊断与治疗杂志, 2021, 35(7): 753-756. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZD202107026.htm TIAN P Z, LI L, FAN Y Y, et al. Diminished ovarian reserve function[J]. Journal of Chinese Practical Diagnosis and Therapy, 2021, 35(7): 753-756. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZD202107026.htm
[15]	张文瑜, 吴欢. 陈氏调经汤联合芬吗通治疗肝肾阴虚型卵巢早衰的临床疗效观察[J]. 中华全科医学, 2022, 20(11): 1934-1937. doi: 10.16766/j.cnki.issn.1674-4152.002739 ZHANG W Y, WU H. Clinical observation of Chen' s menstrual conditioning soup combined with femostone on premature ovarian failure of liver and kidney Yin deficiency syndrome[J]. Chinese Journal of General Practice, 2022, 20(11): 1934-1937. doi: 10.16766/j.cnki.issn.1674-4152.002739
[16]	李善霞, 何东云, 张艳红, 等. 补肾养血方治疗肾阴虚型卵巢储备功能下降的临床观察[J]. 中华中医药学刊, 2019, 37(2): 361-364. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS201902025.htm LI S X, HE D Y, ZHANG Y H, et al. Clinical observation on diminished ovarian reserve of kidney-yin deficiency syndrome treated with kidney-tonifying and blood-nourishing method[J]. Chinese Archives of Traditional Chinese Medicine, 2019, 37(2): 361-364. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS201902025.htm
[17]	彭勋潜. 基于"天癸竭"探讨补肾法治疗绝经后骨质疏松症[J]. 湖北中医杂志, 2019, 41(6): 53-55. https://www.cnki.com.cn/Article/CJFDTOTAL-HBZZ201906021.htm PENG X Q. Study on tonifying kidney therapy for postmenopausal osteoporosis based on "Tiandecui exhaustion"[J]. Hubei Journal of Traditional Chinese Medicine, 2019, 41(6): 53-55. https://www.cnki.com.cn/Article/CJFDTOTAL-HBZZ201906021.htm
[18]	刘振斌, 王刚, 李梦虎. 下肢深静脉血栓形成的中西医治疗进展[J]. 中国中西医结合外科杂志, 2021, 27(1): 149-153. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZX202101037.htm LIU Z B, WANG G, LI M H. Progress of traditional Chinese and Western medicine in the treatment of deep vein thrombosis of lower extremities[J]. Chinese Journal of Surgery of Integrated Traditional and Western Medicine, 2021, 27(1): 149-153. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZX202101037.htm
[19]	刘柳青, 刘雁峰, 王悦竹, 等. 卵巢储备功能下降中医证型特点及用药规律文献挖掘研究[J]. 中国中医药信息杂志, 2021, 28(6): 33-38. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY202106007.htm LIU L Q, LIU Y F, WANG Y Z, et al. Characteristics of TCM syndromes and medication rules in treatment of diminished ovarian reserve based on data mining[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2021, 28(6): 33-38. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY202106007.htm
[20]	刘芸, 王慧, 张莹, 等. 补肾活血法治疗卵巢储备功能减退机制研究进展[J]. 江西中医药, 2021, 52(1): 72-75. https://www.cnki.com.cn/Article/CJFDTOTAL-JXZY202101035.htm LIU Y, WANG H, ZHANG Y, et al. Research progress on mechanism of tonifying kidney and promoting blood circulation in treatment of decreased ovarian reserve function[J]. Jiangxi Journal of Traditional Chinese Medicine, 2021, 52(1): 72-75. https://www.cnki.com.cn/Article/CJFDTOTAL-JXZY202101035.htm
[21]	代琪, 叶臻, 叶俏波, 等. 续断来源考证, 化学成分及药理作用综述[J]. 中国药物评价, 2020, 37(6): 432. doi: 10.3969/j.issn.2095-3593.2020.06.007 DAI Q, YE Z, YE Q B, et al. Textual research of source, chemical constituents and pharmacological action of radixdipsaci: a review[J]. Chinese Journal of Drug Evaluation, 2020, 37(6): 432. doi: 10.3969/j.issn.2095-3593.2020.06.007
[22]	江峰, 李肇暖. AMH﹑FSH和LH联合检测用于评估卵巢储备功能的研究[J]. 中外医疗, 2019, 38(34): 170-172. https://www.cnki.com.cn/Article/CJFDTOTAL-HZZZ201934058.htm JIANG F, LI Z N. Study on combined detection of AMH, FSH and LH for evaluating ovarian reserve function[J]. China Foreign Medical Treatment, 2019, 38(34): 170-172. https://www.cnki.com.cn/Article/CJFDTOTAL-HZZZ201934058.htm
[23]	MOOLHUIJSEN L M E, VISSER J A. Anti-Müllerian hormone and ovarian reserve: update on assessing ovarian function[J]. J Clin Endocrina Metab, 2020, 105(11): 3361-3373. doi: 10.1210/clinem/dgaa513
[24]	钟思苗, 欧婉燕, 黄芳, 等. 经阴道彩色多普勒在评估卵巢储备功能的临床价值[J]. 中国医学创新, 2020, 17(1): 147-150. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYCX202001041.htm ZHONG S M, OU W Y, HUANG F, et al. The clinical value of transvaginal color Doppler in evaluating ovarian reserve function[J]. Chinese Medical Innovations, 2020, 17(1): 147-150. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYCX202001041.htm
[25]	李湘, 杨丽莉, 张伟娜. 阴道彩色多普勒超声对卵巢储备功能的应用价值分析[J]. 中国现代药物应用, 2021, 15(19): 53-55. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY202119019.htm LI X, YANG L L, ZHANG W N. The value of transvaginal color Doppler ultrasound in ovarian reserve function[J]. Chinese Journal of Modern Drug Application, 2021, 15(19): 53-55. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY202119019.htm
[26]	刘传明, 丁利军, 李佳音, 等. 衰老导致卵巢功能低下研究进展[J]. 遗传, 2019, 41(9): 816-826. https://www.cnki.com.cn/Article/CJFDTOTAL-YCZZ201909004.htm LIU C M, DING L J, LI J Y, et al. Advances in the study of ovarian dysfunction with aging[J]. Hereditas, 2019, 41(9): 816-826. https://www.cnki.com.cn/Article/CJFDTOTAL-YCZZ201909004.htm
[27]	程扬眉. 经阴道三维超声在卵巢储备功能减低定量评估及不孕症患者治疗监测中的应用研究[D]. 合肥: 安徽医科大学, 2019. CHENG Y M. The value of transvaginal three-dimensional ultrasound in quantitative evaluation of decreased ovarian reserve function and the treatment detection of infertility patients[D]. Hefei: Anhui Medical University, 2019.
[28]	王木兰, 谢颜潞, 黎爱容. 经阴道超声检查在排卵预测中的价值以及对卵巢储备的评估[J]. 中国实用医药, 2021, 16(22): 50-52. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSSA202122014.htm WANG M L, XIE Y L, LI A R. Value of transvaginal ultrasonography in ovulation prediction and assessment of transvaginal ultrasonography in ovarian reserve[J]. China Practical Medicine, 2021, 16(22): 50-52. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSSA202122014.htm
[29]	SAHIN M, GUVEN S, SAL H, et al. Evaluation of ovarian reserve in unexplained ınfertile cases: a case-controlled study[J]. Middle East Fertil Soc J, 2023, 28. DOI: org/ 10.1186/s43043-023-00154-6.
[30]	刘三英, 高晓艳, 王旭. 三维多普勒超声评估卵巢储备降低女性的卵巢功能的价值研究[J]. 临床和实验医学杂志, 2020, 19(20): 2234-2238. https://www.cnki.com.cn/Article/CJFDTOTAL-SYLC202020032.htm LIU S Y, GAO X Y, W X. Evaluation of the effect of ovarian blood supply on ovulation in diminished ovarian reserve by three dimensional color doppler ultrasound[J]. Journal of Clinical and Experimental Medicine, 2020, 19(20): 2234-2238. https://www.cnki.com.cn/Article/CJFDTOTAL-SYLC202020032.htm

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Tables(5)

Get Citation

PDF

XML

Article Metrics

Article views (43) PDF downloads(3)

Analysis of curative effect of Zishen Huoxue Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve

doi: 10.16766/j.cnki.issn.1674-4152.003547

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Analysis of curative effect of Zishen Huoxue Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve

doi: 10.16766/j.cnki.issn.1674-4152.003547

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content