Volume 22 Issue 6
Jun.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(6): 1000-1004
SHANG Shengli, YAO Yajun, CHEN Ming, XU Shufang. Establishment and validation of an individual nomogram model for predicting the risk of allergic rhinitis in children with bronchial asthma[J]. Chinese Journal of General Practice, 2024, 22(6): 1000-1004. doi: 10.16766/j.cnki.issn.1674-4152.003553
Citation: SHANG Shengli, YAO Yajun, CHEN Ming, XU Shufang. Establishment and validation of an individual nomogram model for predicting the risk of allergic rhinitis in children with bronchial asthma[J]. Chinese Journal of General Practice, 2024, 22(6): 1000-1004. doi: 10.16766/j.cnki.issn.1674-4152.003553
shu

Establishment and validation of an individual nomogram model for predicting the risk of allergic rhinitis in children with bronchial asthma

doi: 10.16766/j.cnki.issn.1674-4152.003553
  • 1.

    Department of Otolaryngology, Head and Neck Surgery, Kailuan General Hospital, Tangshan, Hebei 063000, China

Funds:

 2022166

  • Received Date: 2023-07-16
    Available Online: 2024-07-22
    Abstract
  •   Objective  To analyze the influencing factors of children with bronchial asthma complicated with allergic rhinitis, and to build a personalized predictive nomogram model.  Methods  A total of 358 children with bronchial asthma admitted to Tangshan Third People' s Hospital from July 2019 to November 2022 were collected as the research objects. The risk factors of allergic rhinitis in children with bronchial asthma were analyzed by univariate and multivariate logistic regression. R software was used to build a nomogram model, and the consistency of the nomogram model was verified by calibration curves. Finally, two groups of clinical volumes were collected to evaluate the predictive value and differentiation of the model through the area under the curve of the subject' s working characteristic curve.  Results  One hundred ang eight of 358 children with bronchial asthma complicated with allergic rhinitis (30.17%); the results of the univariate analysis showed that there were obvious differences in smoking by family members, early use of antibiotics, interleukin-8 (IL-8), C-reactive protein (CRP), white blood cell count (WBC) between the allergic rhinitis group and the nonallergic rhinitis group (P < 0.05); that early use of antibiotics, IL-8, CRP, and WBC were influencing factors for children with bronchial asthma complicated with allergic rhinitis (P < 0.05); the slope of the calibration curve of nomogram model for predicting children with bronchial asthma complicated with Allergic rhinitis was close to 1, and the Hosmer-Lemeshow goodness of fit test was χ2=3.107, P=0.927, with good consistency.  Conclusion  This study constructs a nomogram model to predict the risk of allergic rhinitis in children with bronchial asthma based on the four risk factors of early use of antibiotics, IL-8, CRP, and WBC. It has relatively good differentiation and consistency and provides a reference for clinical intervention.

     

    • FullText(HTML)
  • loading
    • References(16)
  • [1]
    CHETTA A, CALZETTA L. Bronchial asthma: an update[J]. Minerva Med, 2022, 113(1): 1-3.
    [2]
    李竹英, 王婷, 李寒梅. 外泌体在支气管哮喘发病机制中的作用[J]. 中华全科医学, 2020, 18(2): 291-294. doi: 10.16766/j.cnki.issn.1674-4152.001228

    LI Z Y, WANG T, LI H M. The role of exosomes in the pathogenesis of bronchial asthma[J]. Chinese Journal of General Practice, 2020, 18(2): 291-294. doi: 10.16766/j.cnki.issn.1674-4152.001228
    [3]
    SCHULER I V C F, MONTEJO J M. Allergic rhinitis in children and adolescents[J]. Pediatr Clin North Am, 2019, 66(5): 981-993. doi: 10.1016/j.pcl.2019.06.004
    [4]
    NAPPI E, PAOLETTI G, MALVEZZI L, et al. Comorbid allergic rhinitis and asthma: important clinical considerations[J]. Expert Rev Clin Immunol, 2022, 18(7): 747-758. doi: 10.1080/1744666X.2022.2089654
    [5]
    MA Y, TANG J, WEN Y, et al. Associations of sleep problems with asthma and allergic rhinitis among Chinese preschoolers[J]. Sci Rep, 2022, 12(1): 8102-8108. doi: 10.1038/s41598-022-12207-3
    [6]
    JUNG M, LEE J Y, RYU G, et al. Beneficial effect of nasal saline irrigation in children with allergic rhinitis and asthma: a randomized clinical trial[J]. Asian Pac J Allergy Immunol, 2020, 38(4): 251-257.
    [7]
    MANDLIK D S, MANDLIK S K. New perspectives in bronchial asthma: pathological, immunological alterations, biological targets, and pharmacotherapy[J]. Immunopharmacol Immunotoxicol, 2020, 42(6): 521-544. doi: 10.1080/08923973.2020.1824238
    [8]
    SHAMSHAD T, KHALIQUE N, SHAMEEM M, et al. Prevalence of bronchial asthma in school going children: a cross-sectional study from uttar pradesh[J]. Indian J Public Health, 2022, 66(1): 22-26.
    [9]
    SCHULER IV C F, MONTEJO J M. Allergic rhinitis in children and adolescents[J]. Immunol Allergy Clin North Am, 2021, 41(4): 613-625. doi: 10.1016/j.iac.2021.07.010
    [10]
    FENG L, SUN F, CHEN Y, et al. Studying the effects of vitamin a on the severity of allergic rhinitis and asthma[J]. Iran J Allergy Asthma Immunol, 2021, 20(6): 648-692.
    [11]
    COX L S, MURPHEY A, HANKIN C. The cost-effectiveness of allergen immunotherapy compared with pharmacotherapy for treatment of allergic rhinitis and asthma[J]. Immunol Allergy Clin North Am, 2020, 40(1): 69-85. doi: 10.1016/j.iac.2019.09.003
    [12]
    王德兵, 唐玉红, 翟传华, 等. 儿童支气管哮喘合并过敏性鼻炎的影响因素及临床干预[J]. 现代医学, 2022, 50(10): 1338-1342. doi: 10.3969/j.issn.1671-7562.2022.10.021

    WANG D B, TANG Y H, ZHAI C H, et al. Influence factors and clinical intervention of children with bronchial asthma complicated with allergic rhinitis[J]. Modern Medicine, 2022, 50(10): 1338-1342. doi: 10.3969/j.issn.1671-7562.2022.10.021
    [13]
    LI Y Q, ZHONG Y, XIAO X P, et al. IL-33/ST2 axis promotes the inflammatory response of nasal mucosal epithelial cells through inducing the ERK1/2 pathway[J]. Innate Immun, 2020, 26(6): 505-513. doi: 10.1177/1753425920918911
    [14]
    GELLRICH D, PFAB F, ORTIZ M, et al. Acupuncture and its effect on cytokine and chemokine profiles in seasonal allergic rhinitis: a preliminary three-armed, randomized, controlled trial[J]. Eur Arch Otorhinolaryngol, 2022, 279(10): 4985-4995. doi: 10.1007/s00405-022-07335-5
    [15]
    MOUSTAFA Y, EL NADY H G, SABER M M, et al. Assessment of allergic rhinitis among children after low-level laser therapy[J]. Open Access Maced J Med Sci, 2019, 7(12): 1968-1973. doi: 10.3889/oamjms.2019.477
    [16]
    PARRINO D, BRESCIA G, ZANOTTI C, et al. Non-eosinophilic chronic rhinosinusitis with nasal polyps: eosinophil, basophil, and neutrophil blood counts before and after surgery[J]. Ann Otol Rhinol Laryngol, 2019, 128(3): 233-240. doi: 10.1177/0003489418818578
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(3)  / Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (62) PDF downloads(4) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return