Volume 22 Issue 7
Jul.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(7): 1102-1107
ZHANG Zongbing, LE Zhenghong, LIU Mulin, HAO Bo. Expression of ITGB2 in gastric cancer and its clinical value[J]. Chinese Journal of General Practice, 2024, 22(7): 1102-1107. doi: 10.16766/j.cnki.issn.1674-4152.003576
Citation: ZHANG Zongbing, LE Zhenghong, LIU Mulin, HAO Bo. Expression of ITGB2 in gastric cancer and its clinical value[J]. Chinese Journal of General Practice, 2024, 22(7): 1102-1107. doi: 10.16766/j.cnki.issn.1674-4152.003576
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Expression of ITGB2 in gastric cancer and its clinical value

doi: 10.16766/j.cnki.issn.1674-4152.003576

  • Department of Gastrointestinal Surgery, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 2108085MH291

  • Received Date: 2024-01-07
    Available Online: 2024-09-05
    Abstract
  •   Objective  To investigate the expression of ITGB2 in gastric cancer tissues and its correlation with malignant progression of gastric cancer, and to analyze the possible biological processes of ITGB2 by bioinformatics.  Methods  The expression level of ITGB2 in gastric cancer tissues and its correlation with malignant progression of gastric cancer were analyzed using online database. A total of 107 patients with gastric cancer who received radical gastrectomy in the First Affiliated Hospital of Bengbu Medical University from February 2016 to December 2018 were included. The expression of ITGB2 in gastric cancer tissues and its effect on the prognosis of patients with gastric cancer were analyzed. The biological processes and signaling pathways involved in ITGB2 were analyzed using DAVID database. TIMER2.0 database was used to explore the potential relationship between ITGB2 expression and various immune cell infiltration.  Results  Immunohistochemical results showed that ITGB2 was highly expressed in gastric cancer tissues (3.465±1.037 in gastric cancer tissues and 1.000±0.271 in para-cancerous tissues, t=22.653, P < 0.001). The results of qRT-PCR test confirmed that the mRNA level of ITGB2 in gastric cancer tissue was significantly higher than that in paracancer tissue (P < 0.001). Western blotting test further verified the above experimental results. The survival rate of patients with high ITGB2 expression group was lower than that of patients with low ITGB2 expression group (log-rank χ2=38.394, P < 0.001). Univariate and multivariate analysis showed that high expression of ITGB2 in gastric cancer tissue, CEA≥5 μg/L in peripheral blood, CA19-9≥37 kU/L, clinical T3-T4 and N2-N3 (P < 0.05) were independent risk factors affecting the prognosis of patients with gastric cancer. Bioinformatic analysis showed that ITGB2 was involved in the regulation of immune response.  Conclusion  ITGB2 is highly expressed in gastric cancer and is involved in the malignant evolution of gastric cancer, which is closely related to the poor prognosis and immune cell infiltration of patients with gastric cancer.

     

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