Volume 22 Issue 7
Jul.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(7): 1209-1211
ZHOU Lei, HUANG Xueshuang, LI Huimin, JIN Xin, WANG Hai. Expression and correlation of four kinds of cytokines in patients with Hashimoto's thyroiditis or papillary thyroid carcinoma[J]. Chinese Journal of General Practice, 2024, 22(7): 1209-1211. doi: 10.16766/j.cnki.issn.1674-4152.003601
Citation: ZHOU Lei, HUANG Xueshuang, LI Huimin, JIN Xin, WANG Hai. Expression and correlation of four kinds of cytokines in patients with Hashimoto's thyroiditis or papillary thyroid carcinoma[J]. Chinese Journal of General Practice, 2024, 22(7): 1209-1211. doi: 10.16766/j.cnki.issn.1674-4152.003601
shu

Expression and correlation of four kinds of cytokines in patients with Hashimoto's thyroiditis or papillary thyroid carcinoma

doi: 10.16766/j.cnki.issn.1674-4152.003601
  • 1.

    Department of Laboratory, Hangzhou Children's Hospital, Hangzhou, zhejiang 310006, China

Funds:

 LGF22H160047

  • Received Date: 2023-11-23
    Available Online: 2024-09-05
    Abstract
  •   Objective  To analyzed the expression of serum Interleukin-2 (IL-2), Interleukin 12 P70 (IL-12P70), interleukin-10 (IL-10) and interleukin-17 (IL-17) in Hashimoto's thyroiditis carcinoma (HT) and papillary thyroid carcinoma (PTC), to investigate the role of 4 kinds of cytokines in HT and PTC.  Methods  Thirty patients with Hashimoto's thyroiditis, 35 patients with papillary thyroid carcinoma, and thirty healthy individuals were selected from Tongde Hospital of Zhejiang Province from July 2022 to June 2023. They were divided into HT group, PTC group, and healthy control group. The serum levels of IL-2, IL-12P70, IL-10, and IL-17 were detected by flow cytometry.  Results  Compared with the healthy control group, the serum levels of IL-2, IL-12P70, and IL-17 were significantly higher in both the PTC and HT groups (P < 0.05). Compared with the HT group, the serum level of IL-10 was significantly increased in the PTC group [(9.46±2.22) pg/mL vs. (7.44±1.97) pg/mL, P < 0.05]. In the HT group, thyroid peroxidase antibody (TPOAb) levels were negatively correlated with the level of IL-10 and positively correlated with the level of IL-17 (P < 0.05). The level of thyroglobulin antibody (TgAb) was negatively correlated with the level of IL-10 (P < 0.05). The levels of IL-2, IL-12P70, IL-10, and IL-17 in thyroid tumor patients showed no significant differences after total thyroidectomy or thyroid gland with isthmus resection(P>0.05).  Conclusion  The serum levels of IL-2, IL-12P70, and IL-17 elevated in PTC and HT patients, while the serum levels of IL-10 decreased in HT patients and correlated with TPOAb and TgAb levels. There were no significant changes in the levels of these cytokines after total thyroidectomy or thyroid gland with isthmus resection in patients with PTC.

     

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