Volume 22 Issue 7
Jul.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(7): 1222-1226
LI Zhang, LYU Jing, ZHAO Xiaoke, XU Hong, ZHANG Ling, ZHU Min. A study on the efficacy of transcranial magnetic stimulation combined with rehabilitation training in children with autism spectrum disorders and analysis of low-frequency amplitude[J]. Chinese Journal of General Practice, 2024, 22(7): 1222-1226. doi: 10.16766/j.cnki.issn.1674-4152.003604
Citation: LI Zhang, LYU Jing, ZHAO Xiaoke, XU Hong, ZHANG Ling, ZHU Min. A study on the efficacy of transcranial magnetic stimulation combined with rehabilitation training in children with autism spectrum disorders and analysis of low-frequency amplitude[J]. Chinese Journal of General Practice, 2024, 22(7): 1222-1226. doi: 10.16766/j.cnki.issn.1674-4152.003604
shu

A study on the efficacy of transcranial magnetic stimulation combined with rehabilitation training in children with autism spectrum disorders and analysis of low-frequency amplitude

doi: 10.16766/j.cnki.issn.1674-4152.003604
  • 1.

    Department of Rehabilitation, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China

Funds:

 QNRC2016089

 FYX201907

 YKK19108

  • Received Date: 2024-03-03
    Available Online: 2024-09-05
    Abstract
  •   Objective  To observe the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on the core symptoms of children with autism spectrum disorders (ASD) by ALFF analysis of resting-state functional magnetic resonance imaging.  Methods  Thirty-four children with ASD from the Department of Rehabilitation of Children's Hospital of Nanjing Medical University from October 2021 to December 2023 were divided into two groups (ASD1 and ASD2) by a randomized numeric table method. The ASD1 group was given regular training and low frequency rTMS stimulation to the dorsolateral prefrontal region (DLPFC), while the ASD2 group was given regular training and sham stimulation. One case was dislodged from each group. Core symptoms were assessed using the autism behavioral scale (ABC), autism rating scale (CARS), repetitive stereotyped behavioral scale-revised (RBS-R), and autism treatment evaluation scale (ATEC) before and after 12 weeks of treatment. Resting-state fMRI scans were performed in both groups before and after treatment, and their resting-state fMRI data were analyzed to observe improvements in core symptoms and changes in ALFF indexes in the resting state.  Results  After 12 weeks of treatment, the CARS, RBS-R, and ATEC scores of children with ASD in both groups were significantly improved compared to those before treatment. The total scores of CARS [(32.50±1.63) points vs. (34.75±3.94) points], RBS-R [7.00 (6.00, 7.00) points vs. 8.00 (7.00, 11.75) points], and ATEC [(60.20±12.29) points vs. (69.80±13.52) points] in the ASD1 group were better than those in the ASD2 group after treatment (P < 0.05). Increased ALFF in the ASD1 group was observed mainly in the superior temporal gyrus, inferior frontal gyrus, and parahippocampal gyrus, while no significant changes were seen in the ASD2 group before and after treatment.  Conclusion  On the basis of conventional rehabilitation intervention, low-frequency rTMS therapy can effectively improve the core symptoms and behavioral evaluation indexes of children with ASD, which is confirmed by the convergence of compensation in related brain regions at rest.

     

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