Study on the related mechanisms of Bianxue Formula in improving clinical symptoms of patients with internal hemorrhoids

WANG Qi; WANG Hua; TONG Lei; QIN Mengting

doi:10.16766/j.cnki.issn.1674-4152.003605

Volume 22 Issue 7

Jul. 2024

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Article Navigation > Chinese Journal of General Practice > 2024 > 22(7): 1227-1229

WANG Qi, WANG Hua, TONG Lei, QIN Mengting. Study on the related mechanisms of Bianxue Formula in improving clinical symptoms of patients with internal hemorrhoids[J]. Chinese Journal of General Practice, 2024, 22(7): 1227-1229. doi: 10.16766/j.cnki.issn.1674-4152.003605

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WANG Qi, WANG Hua, TONG Lei, QIN Mengting. Study on the related mechanisms of Bianxue Formula in improving clinical symptoms of patients with internal hemorrhoids[J]. Chinese Journal of General Practice, 2024, 22(7): 1227-1229. doi: 10.16766/j.cnki.issn.1674-4152.003605

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Study on the related mechanisms of Bianxue Formula in improving clinical symptoms of patients with internal hemorrhoids

doi: 10.16766/j.cnki.issn.1674-4152.003605

WANG Qi^{1
,
,}
, WANG Hua²
, TONG Lei¹
, QIN Mengting¹

1.
Department of Anorectal, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang 314001, China

Funds:

2022ZB349

Received Date: 2024-03-11
Available Online: 2024-09-05

Abstract

Abstract

Objective In order to improve the clinical treatment level of internal hemorrhoids and explore a scientifically effective combination of traditional Chinese and Western medicine treatment approach, this study explores the clinical effect and pharmacological mechanism of Bianxue Formula to improve clinical symptoms in patients with internal hemorrhoids. Methods A total of 150 patients with grade Ⅰ and Ⅱ internal hemorrhoids admitted to the Department of Anorectal of Jiaxing Hospital of Traditional Chinese Medicine from January 2020 to December 2023 were selected as the research objects. According to the random number table method, they were divided into the control group (75 cases) and the observation group (75 cases). The control group was treated with compound cabbage ester suppository, while the observation group was treated with an additional formula for constipation and bleeding on the basis of compound carrageenan suppositories. The improvement of clinical symptoms such as rectal bleeding, pain, and hemorrhoid mucosal status before and after treatment were observed, the level of clinical efficacy was evaluated, the changes in serum vascular endothelial factor and inflammatory factor levels were detected, and the adverse drug reactions during treatment were followed up. Results After treatment, the observation group had lower scores for rectal bleeding, falling pain, and hemorrhoid mucosal status compared to the control group (P < 0.001). The overall effective rate of hemorrhoid treatment in the observation group [93.33% (70/75)] was higher than the control group [74.67% (56/75), P < 0.05]. The levels of vascular endothelial factors in serum such as endothelin 1 (EF-1), intercellular adhesion factor-1 (ICAM-1), vascular cell adhesion factor-1 (VCAM-1), and endothelial nitric oxide synthase (eNOS) in the observation group after treatment was lower than the control group (P < 0.001). The content of inflammatory factors in serum such as IL-1β, IL-6, IL-8, and TNF-α in the observation group after treatment were lower than the control group (P < 0.001). Conclusion The combination of Bianxue Formula and compound cabbage ester suppository can effectively alleviate clinical symptoms in patients with internal hemorrhoids, improve clinical efficacy, and the improvement of clinical symptoms is closely related to the pharmacological mechanism of Bianxue Formula in inhibiting vascular endothelial injury and inflammatory response.
- Internal hemorrhoids,
- Compound cabbage ester suppository,
- Bianxue Formula,
- Clinical symptoms,
- Vascular endothelial injury,
- Pharmacological mechanism

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References(18)

References

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