Volume 22 Issue 8
Aug.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(8): 1364-1366
XIANG Li ' e, SHANG Lili, WANG Jiejie. Clinical observation of Zixian Pills combined with azithromycin in the treatment of children with henoch-schonlein purpura complicated with Mycoplasma pneumoniae infection[J]. Chinese Journal of General Practice, 2024, 22(8): 1364-1366. doi: 10.16766/j.cnki.issn.1674-4152.003637
Citation: XIANG Li ' e, SHANG Lili, WANG Jiejie. Clinical observation of Zixian Pills combined with azithromycin in the treatment of children with henoch-schonlein purpura complicated with Mycoplasma pneumoniae infection[J]. Chinese Journal of General Practice, 2024, 22(8): 1364-1366. doi: 10.16766/j.cnki.issn.1674-4152.003637
shu

Clinical observation of Zixian Pills combined with azithromycin in the treatment of children with henoch-schonlein purpura complicated with Mycoplasma pneumoniae infection

doi: 10.16766/j.cnki.issn.1674-4152.003637

  • Department of Pediatrics, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230000, China

Funds:

 2023ZYLCYJ05-05

  • Received Date: 2024-04-02
    Available Online: 2024-11-19
    Abstract
  •   Objective  To investigate the efficacy and safety of Zixian Pills combined with azithromycin in the treatment of Henoch-Schönlein purpura (HSP) complicated by Mycoplasma pneumoniae infection.  Methods  One hundred cases of children with HSP complicated by Mycoplasma. pneumoniae infection who were treated in the pediatric ward of the First Affiliated Hospital of Anhui University of Chinese Medicine from January 2021 to February 2024 were selected. They were divided into observation group (50 cases) and control group (50 cases) according to random number table method. The control group was given azithromycin and basic treatment for HSP, and the observation group was given oral Zixian Pills on the basis treatment of the control group, both of which were treated for 7-14 days. The improvement in traditional Chinese medicine (TCM) syndrome scores, clinical efficacy and adverse drug reactions were evaluated in the two groups, and the levels of urinary red blood cells, urinary microalbumin and urinary beta 2-microglobulin were measured.  Results  Before treatment, there was no significant difference in TCM syndrome scores between the two groups (P>0.05); After treatment, the scores of TCM syndromes in both groups were lower than those before treatment (P < 0.05); After treatment, the TCM syndrome score in the observation group [1.00 (1.00, 2.00)] was lower than that in the control group [2.00 (1.00, 2.00), P < 0.05]. The overall response rate (ORR) in the observation group was superior to that in the control group [92.0% (46/50) vs. 76.0% (38/50), P < 0.05]. There was no significant difference in urinary erythrocytes, urinary microalbumin and urinary beta 2-microglobulin between the two groups before treatment (P>0.05); there were significant differences in urinary erythrocytes, urinary microalbumin and urinary beta 2-microglobulin between the two groups after treatment (P < 0.05). There was no significant difference in the incidence of adverse events between the two groups (P>0.05).  Conclusion  The treatment of HSP complicated by Mycoplasma. pneumoniae infection in children with Zixian Pills combined with azithromycin has obvious effects on improving TCM syndrome scores and reducing renal injury, and it has good safety.

     

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    • References(22)
  • [1]
    OZEN S, MARKS S D, BROGAN P, et al. European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis-the SHARE initiative[J]. Rheumatology, 2019, 58(9): 1607-1616. doi: 10.1093/rheumatology/kez041
    [2]
    高春林, 夏正坤. 从过敏性紫癜到IgA血管炎—发病机制新认识[J]. 中国实用儿科杂志, 2022, 37(1): 12-16.

    GAO C L, XIA Z K. From henoch-schonlein purpura to IgA vasculitis: a newinsight of pathogenesis[J]. Chinese Journal of Pediatrics, 2022, 37(1): 12-16.
    [3]
    PILLEBOUT E, SUNDERKOTTER C. IgA vasculitis[J]. Semin Immunopathol, 2021, 43(5): 729-730. doi: 10.1007/s00281-021-00874-9
    [4]
    SHANG X P, WU J G, CHENG Y, HU H B. Epidemiology and clinical characteristics of Henoch-Schönlein purpura associated with Mycoplasma pneumoniae infection in 131 children in Hubei Province, China[J]. Mediterr J Hematol Infect Dis, 2021, 13(1): e2021037. DOI: 10.4084/MJHID.2021.037.
    [5]
    梅昭均, 王燕, 张伟. 肺炎支原体感染与过敏性紫癜临床分型及其肾脏损害的相关性研究[J]. 临床肺科杂志, 2019, 24(7): 1175-1179.

    MEI Z J, WANG Y, ZHANG W. Correlation of mycoplasma pneumonia infection with clinical classification of Henoch-Schonlein purpura and renal damage[J]. Journal of Clinical Pulmonary Medicine, 2019, 24(7): 1175-1179.
    [6]
    LIU C, LUO L, FU M, et al. Analysis of children with Henoch-Scholein purpurase condary to infection[J]. Clin Rheumatol, 2022, 41(3): 803-810. doi: 10.1007/s10067-021-06007-9
    [7]
    张奇文, 朱锦善. 实用中医儿科学[M]. 北京: 中国中医药出版社, 2016: 1012-1016.

    ZHANG Q W, ZHU J S. Practical pediatrics of traditional Chinese medicine[M]. Beijing: China press of traditional Chinese medicine, 2016: 1012-1016.
    [8]
    国家药品监督管理局. 关于发布证候类中药新药临床研究技术指导原则的通告(2018年第109号)[EB/OL]. (2018-11-06)[2022-03-05]https://www.cqn.com.cn/ms/content/2018-11/07/content_6431425.htm.

    State Administration of Traditional Chinese Medicine. Circular on the issuance of technical guidelines for clinical research of new traditional Chinese medicines of syndrome type (No. 109 of 2018)[EB/OL]. (2018-11-06)[2022-03-05]. https://www.cqn.com.cn/ms/content/2018-11/07/content_6431425.htm.
    [9]
    韩冰虹, 常丽, 苑天桐, 等. 过敏性紫癜中医症状分级量化标准的研究[J]. 中国中医药科技, 2010, 17(1): 3-5.

    HAN B H, CHANG L, YUAN T T, et al. Study on quantitative standard of TCM symptom grading of anaphylactoid purpura[J]. Chinese Journal of Traditional Medical Science and technology, 2010, 17(1): 3-5.
    [10]
    国家中医药管理局医政司. 中医病证诊断疗效标准[S]. 北京: 中国中医药出版社, 2019: 19.

    Secretary for State Administration of Traditional Chinese Medicine and medical services. Diagnostic and curative effect standard of TCM disease and syndrome[S]. Beijing: China Press of Traditional Chinese Medicine, 2019: 19.
    [11]
    中华中医药学会. 中医儿科常见病诊疗指南: ZYYXH/T247~286—2012[S]. 北京: 中国中医药出版社, 2012: 175-180.

    Chinese Society of Traditional Chinese Medicine. A guide to the diagnosis and treatment of common pediatric diseases in traditional Chinese medicine: ZYYXH/T247-286-2012[S]. Beijing: China Press of Traditional Chinese Medicine, 2012: 175-180.
    [12]
    儿童过敏性紫癜性肾炎中西医结合循证小组. 儿童过敏性紫癜性肾炎中西医结合诊疗指南(2023)[J]. 北京中医药大学学报, 2024, 47(1): 133-140.

    Evidence-Based Group on Integrated Chinese and Western Medicine for Children with Henoch-Sch?nlein Purpura Nephritis. A guide to integrated Chinese and western medicine for the diagnosis and treatment of Henoch-Sch?nlein purpura nephritis in children(2023)[J]. Journal of Beijing University of Chinese Medicine, 2024, 47(1): 133-140.
    [13]
    曹永丽, 焦琼杰, 祝静, 等. 肺炎支原体感染与儿童过敏性紫癜及紫癜性肾炎关系的研究进展[J]. 中国医药, 2023, 18(5): 765-768.

    CAO Y L, JIAO Q J, ZHU J, et al. Research progress on the relationship of Mycoplasma infection to henoch-schonlein purpura and henoch-schonlein purpura nephritis in children[J]. China Medicine, 2023, 18(5): 765-768.
    [14]
    杨祎, 张春生, 徐乐, 等. 儿童过敏性紫癜感染的临床及肾损伤特点[J]. 中华医院感染学杂志, 2021, 31(5): 791-795.

    YANG Y, ZHANG C S, XU L, et al. Clinical characteristics of children with Henoch-Schonlein purpura and renal damage[J]. Chinese Journal of Nosocomiology, 2021, 31(5): 791-795.
    [15]
    畅晓元, 刘岩. 儿童紫癜性肾炎的相关因素及血清IgA/C3的预测价值分析[J]. 实用药物与临床, 2019, 22(9): 956-959.

    CHANG X Y, LIU Y. Analysis of correlative factors and predictive value of serum Ig A/C3 ratio for Henoch-Schonlein purpura nephritis in children[J]. Practical Pharmacy and Clinical Remedies, 2019, 22(9): 956-959.
    [16]
    张燕, 刘伟华. 肺炎支原体感染与儿童过敏性紫癜关系探讨[J]. 陕西医学杂志, 2021, 50(2): 170-172, 176.

    ZHANG Y, LIU W H. Clinical relevance between the infection of mycoplasma pneumoniae and Henoch-Schonlein purpura in children[J]. Shaanxi Medical Journal, 2021, 50(2): 170-176.
    [17]
    涂鹏, 窦海伟, 史大伟, 等. 流感样病例中肺炎支原体感染与耐药情况研究[J]. 中国全科医学, 2022, 25(2): 145-148, 158.

    TU P, DOU H W, SHI D W, et al. Infection and drug resistance of mycoplasma pneumonia: an analysis of influenza-like illness[J]. Chinese General Practice, 2022, 25(2): 145-148, 158.
    [18]
    曾兆彬, 王奇伟, 刘鼎立, 等. 不同剂量甲泼尼龙对小儿难治性肺炎支原体肺炎的疗效分析[J]. 中华全科医学, 2020, 18(7): 1150-1152, 1226. doi: 10.16766/j.cnki.issn.1674-4152.001452

    ZENG Z B, WANG Q W, LIU D L, et al. Effect of different doses of methylprednissolone on refractory mycoplasma pneumoniae pneumonia in children[J]. Chinese Journal of General Practice, 2020, 18(7): 1150-1152, 1226. doi: 10.16766/j.cnki.issn.1674-4152.001452
    [19]
    吴超雄, 王爱敏, 蔡振荡. 肺炎支原体23SrRNA突变与患儿临床特征及耐药性的相关性[J]. 中华全科医学, 2021, 19(4): 603-606. doi: 10.16766/j.cnki.issn.1674-4152.001872

    WU C X, WANG A M, CAI Z D. Correlation between 23rRNA mutation of mycoplasma pneumoniae and clinical characteristics and drug resistance in children[J]. Chinese Journal of General Practice, 2021, 19(4): 603-606. doi: 10.16766/j.cnki.issn.1674-4152.001872
    [20]
    岳慧芳, 任献青. 基于"平治于权衡, 去宛陈莝"辨治儿童过敏性紫癜思路探析[J]. 江苏中医药, 2024, 56(2): 30-32.

    YUE H F, REN X Q. Based on the thought of "Ping zhi yu quan heng, qu wan chen cuo", this paper explores the treatment of children Henoch-Sch?nlein purpura[J]. Jiangsu Journal of Traditional Chinese Medicine, 2024, 56(2): 30-32.
    [21]
    黄后艳, 桂金贵, 周陶成. 紫仙丹对过敏性紫癜的疗效分析[J]. 安徽医专学报, 2023, 22(2): 41-43.

    HUANG H Y, GUI J G, ZHOU T C. Effect of Zixiandan on FDP and D-D in allergic purpura[J]. Journal of Anhui Medical College, 2023, 22(2): 41-43.
    [22]
    沈克彦. 紫仙丹对过敏性紫癜患儿β-2微球蛋白、尿微量白蛋白的影响[J]. 陕西中医, 2020, 41(10): 1382-1384.

    SHEN K Y. The effect of Zixian Dan on β-2-microglobulin and urinary microalbumin in children with Henoch-Sch?nlein purpura[J]. Shaanxi Journal of Traditional Chinese Medicine, 2020, 41(10): 1382-1384.
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