Volume 22 Issue 8
Aug.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(8): 1395-1398
LIU Kai, WU Jing, XU Xun, GUAN Zheng, XU Li, ZHANG Jun. Analysis of screening and identification of irregular antibodies in 39 671 blood transfusion patients[J]. Chinese Journal of General Practice, 2024, 22(8): 1395-1398. doi: 10.16766/j.cnki.issn.1674-4152.003644
Citation: LIU Kai, WU Jing, XU Xun, GUAN Zheng, XU Li, ZHANG Jun. Analysis of screening and identification of irregular antibodies in 39 671 blood transfusion patients[J]. Chinese Journal of General Practice, 2024, 22(8): 1395-1398. doi: 10.16766/j.cnki.issn.1674-4152.003644
shu

Analysis of screening and identification of irregular antibodies in 39 671 blood transfusion patients

doi: 10.16766/j.cnki.issn.1674-4152.003644

  • Department of Blood Transfusion, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 KJ2020A0561

  • Received Date: 2023-11-17
    Available Online: 2024-11-19
    Abstract
  •   Objective   To analyze the screening and identification results of irregular antibodies in patients with blood transfusion, and to explore the relationship between irregular antibodies and gender, blood transfusion history, and pregnancy history.   Methods   The screening and identification results of irregular antibodies in 39 671 transfusion patients from January 2021 to December 2022 were obtained from the hospital electronic medical record system. The number of positive cases for irregular antibodies was recorded, the distribution of irregular antibodies was analyzed, and the relationship between the positive rate and specificity of irregular antibodies and patient gender, transfusion history, and pregnancy history was explored.   Results   Among the 39 671 transfusion patients, a total of 365 cases tested positive for irregular antibodies, with a positivity rate of 0.92%. Among them, the highest proportion was positive antibodies in the Rh blood type system (213 cases, accounting for 58.36%). The data showed that among the 365 patients with positive irregular antibodies, females (228 cases, 62.47%) had a higher proportion than males (137 cases, 37.53%), and the positivity rate of Rh blood type system antibodies in female patients (143 cases, 62.72%) was significantly higher than that in males (70 cases, 51.09%; P=0.037). Patients with a history of transfusion and those with a history of pregnancy were more likely to have positive Rh blood type system antibodies (P < 0.05).   Conclusion   Women, blood transfusion history and pregnancy history will increase the probability of positive results on irregular antibody screening. While irregular antibody screening and identification for patients who have conventional transfusion therapy are carried out, the detection for women, patients with blood transfusion history or pregnancy history should be especially strengthened.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    闫烨. 输血患者排除抗筛假阴性的意义探讨[J]. 中华全科医学, 2023, 21(10): 1732-1735. doi: 10.16766/j.cnki.issn.1674-4152.003212

    YAN Y. An examination of the significance of excluding anti-screening false negatives in blood transfusion patients[J]. Chinese Journal of General Practice, 2023, 21(10): 1732-1735. doi: 10.16766/j.cnki.issn.1674-4152.003212
    [2]
    金颖, 吕永强, 石娉华. 不规则抗体筛查及抗体特异性鉴定对输血患者预后的影响[J]. 吉林医学, 2023, 44(8): 2213-2215. doi: 10.3969/j.issn.1004-0412.2023.08.050

    JIN Y, LYU Y Q, SHI P H. Impact of irregular antibody screening and antibody specificity identification on the prognosis of transfused patients[J]. Jilin Medical Jouranl, 2023, 44(8): 2213-2215. doi: 10.3969/j.issn.1004-0412.2023.08.050
    [3]
    NI H, SUN X Y, CONG H. Analysis of specificity and distribution characteristics of red blood cell irregular antibodies[J]. Lab Med, 2023, 54(5): 507-511. doi: 10.1093/labmed/lmac160
    [4]
    李秀伶, 张东敏, 孔庆和, 等. Rh抗原分型及血型不规则抗体筛检在精准输血中的应用效果研究[J]. 中国临床新医学, 2023, 16(3): 274-277. doi: 10.3969/j.issn.1674-3806.2023.03.14

    LI X L, ZHANG D M, KONG Q H, et al. A study on the application effect of Rh antigen typing and irregular blood group antibody screening in precise blood transfusion[J]. Chinese Journal of New Clinical Medicine, 2023, 16(3): 274-277. doi: 10.3969/j.issn.1674-3806.2023.03.14
    [5]
    胡丽华. 临床输血学检验技术实验指导[M]. 北京: 人民卫生出版社, 2015: 16-18.

    HU L H. Laboratory Guidance for Clinical Blood Transfusion Laboratory Techniques[M]. Beijing: People ' s Health Publishing House, 2015: 16-18.
    [6]
    秦华, 程菲, 朱梅, 等. 拟输血患者不规则抗体筛查结果分析[J]. 中国输血杂志, 2019, 32(6): 560-564.

    QIN H, CHENG F, ZHU M, et al. Analysis of screening results of irregular antibodies in patients receiving blood transfusion[J]. Chin J Blood Transfusion Jan, 2019, 32(6): 560-564.
    [7]
    王琛, 安宁, 杨世明, 等. 410例Rh血型不规则抗体特异性鉴定结果的分析[J]. 细胞与分子免疫学杂志, 2021, 37(9): 835-838.

    WANG C, AN N, YANG S M, et al. Analysis of the results of the specific identification of 410 cases of irregular antibodies to Rh blood groups[J]. Chin J Cell Mol Immunol, 2021, 37(9): 835-838.
    [8]
    贾军会, 高晓云, 田华, 等. Rh表型配合性输注红细胞疗效[J]. 中国实验血液学杂志, 2022, 30(3): 865-869.

    JIA J H, GAO X Y, TIAN H, et al. The efficacy of Rh phenotype matched blood transfusion[J]. Journal of Experimental Hematology, 2022, 30(3): 865-869.
    [9]
    李莺, 朱永亮, 许进明, 等. Rh血型主要抗原配合性输注的可行性研究及效果分析[J]. 南京医科大学学报(自然科学版), 2022, 42(9): 1305-1308.

    LI Y, ZHU Y L, XU J M, et al. Feasibility study and effect analysis of Rh blood group major antigen-compatible transfusion[J]. Journal of Nanjing Medical University(Natural Sciences), 2022, 42(9): 1305-1308.
    [10]
    詹廷西, 王静, 徐丹丹, 等. 输血前患者不规则抗体筛查及鉴定的临床意义探讨[J]. 中国免疫学杂志, 2021, 37(3): 335-338, 345. doi: 10.3969/j.issn.1000-484X.2021.03.014

    ZHAN T X, WANG J, XU D D, et al. Clinical significance of irregular antibody screening and identification before blood transfusion[J]. Chinese Journal of Immunology, 2021, 37(3): 335-338, 345. doi: 10.3969/j.issn.1000-484X.2021.03.014
    [11]
    张群, 孙倩倩, 江新泉. 泰安地区16 648例妊娠妇女不规则抗体筛查分析[J]. 泰山医学院学报, 2020, 41(4): 257-259. doi: 10.3969/j.issn.1004-7115.2020.04.006

    ZHANG Q, SUN Q Q, JIANG X Q. Analysis of 16 648 pregnant women with irregular antibody screening in Taian[J]. Journal of Taishan Medical College, 2020, 41(4): 257-259. doi: 10.3969/j.issn.1004-7115.2020.04.006
    [12]
    肖洁, 高守曦, 宋辉, 等. 妊娠期妇女红细胞血型不规则抗体检测和管理实践初探[J]. 中国输血杂志, 2020, 33(6): 582-585.

    XIAO J, GAO S X, SONG H, et al. Preliminary exploration of irregular antibody testing and management in women during pregnancy[J]. Chin J Blood Transfusion Jan, 2020, 33(6): 582-585.
    [13]
    谢秀华, 杨玉发, 黄守民, 等. 深圳市无偿献血者不规则抗体筛查及鉴定结果分析[J]. 检验医学与临床, 2022, 19(7): 946-948. doi: 10.3969/j.issn.1672-9455.2022.07.021

    XIE Y H, YANG Y F, HUANG S M, et al. Analysis of the results of irregular antibody screening and identification of blood donors in Shenzhen, China[J]. Lab Med Clin, 2022, 19(7): 946-948. doi: 10.3969/j.issn.1672-9455.2022.07.021
    [14]
    侯瑞琴, 杨洪燕, 崔银平, 等. 患者不规则抗体鉴定结果分析及其临床意义[J]. 中国实验血液学杂志, 2020, 28(3): 961-966.

    HOU R Q, YANG H Y, CUI Y P, et al. Analysis of the irregular antibodies of the patients and its clinical significance[J]. Journal of Experimental Hematology, 2020, 28(3): 961-966.
    [15]
    钟昌瑞, 阙庆和, 黄巧莉, 等. 住院患者不规则抗体阳性率及特异性分析[J]. 临床血液学杂志, 2023, 36(4): 255-259.

    ZHONG C Y, QUE Q H, HUANG Q L, et al. Analysis of irregular antibody positivity and specificity in hospitalized patients[J]. J Clin Hematol, 2023, 36(4): 255-259.
    [16]
    AYENEW A A. Prevalence of rhesus D-negative blood type and the challenges of rhesus D immunoprophylaxis among obstetric population in Ethiopia: a systematic review and meta-analysis[J]. Matern Health Neonatol Perinatol, 2021, 7(1): 8. doi: 10.1186/s40748-021-00129-3
    [17]
    郑艳玲, 洪强, 王前明. 非ABO新生儿溶血病的调查分析[J]. 中国实验血液学杂志, 2021, 29(4): 1330-1333.

    ZHENG Y L, HONG Q, WANG Q M, et al. Investigation and analysis of non-ABO hemolytic disease of the newborn[J]. Journal of Experimental Hematology, 2021, 29(4): 1330-1333.
    [18]
    王丽娜, 张勤, 宋怀珠, 等. 不规则抗体筛查试验在安全输血中的重要性[J]. 实用检验医师杂志, 2022, 14(3): 241-244. doi: 10.3969/j.issn.1674-7151.2022.03.005

    WANG L N, ZHANG Q, SONG H Z, et al. The importance of irregular antibody screening tests in safe blood transfusion[J]. Chin J Clin Pathol, 2022, 14(3): 241-244. doi: 10.3969/j.issn.1674-7151.2022.03.005
    [19]
    魏秀萍, 赵瑞东. 浅谈微柱凝胶法交叉配血不合的原因及处理[J]. 中华全科医学, 2011, 9(11): 68-69. https://www.cnki.com.cn/Article/CJFDTotal-SYQY201101041.htm

    WEI X P, ZHAO R D. Causes and treatment of cross-matching incompatibility by microcolumn gel method[J]. Chinese Journal of General Practice, 2011, 9(11): 68-69. https://www.cnki.com.cn/Article/CJFDTotal-SYQY201101041.htm
    [20]
    夏帆, 付有荣, 刘潘. 268例不规则抗体筛查阳性患者紧急输血体会[J]. 武汉大学学报(医学版), 2022, 43(6): 993-996.

    XIA F, FU Y R, LIU P. Experience of emergency blood transfusion in 268 patients with positive irregular antibody screening[J]. Medical Journal of Wuhan University, 2022, 43(6): 993-996.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (1) PDF downloads(0) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return