The predictive value of uric acid to albumin ratio for medium and long-term all-cause mortality in patients with CTO

ZHANG Jingjing; ZHAO Yufei; ZHU Hualiang; ZHU Xiaoxia; LIU Zeyan; HUANG Zheng

doi:10.16766/j.cnki.issn.1674-4152.003667

Volume 22 Issue 9

Sep. 2024

Turn off MathJax

Article Contents

Article Navigation > Chinese Journal of General Practice > 2024 > 22(9): 1496-1499

ZHANG Jingjing, ZHAO Yufei, ZHU Hualiang, ZHU Xiaoxia, LIU Zeyan, HUANG Zheng. The predictive value of uric acid to albumin ratio for medium and long-term all-cause mortality in patients with CTO[J]. Chinese Journal of General Practice, 2024, 22(9): 1496-1499. doi: 10.16766/j.cnki.issn.1674-4152.003667

Citation:

ZHANG Jingjing, ZHAO Yufei, ZHU Hualiang, ZHU Xiaoxia, LIU Zeyan, HUANG Zheng. The predictive value of uric acid to albumin ratio for medium and long-term all-cause mortality in patients with CTO[J]. Chinese Journal of General Practice, 2024, 22(9): 1496-1499. doi: 10.16766/j.cnki.issn.1674-4152.003667

Citation:

ZHANG Jingjing, ZHAO Yufei, ZHU Hualiang, ZHU Xiaoxia, LIU Zeyan, HUANG Zheng. The predictive value of uric acid to albumin ratio for medium and long-term all-cause mortality in patients with CTO[J]. Chinese Journal of General Practice, 2024, 22(9): 1496-1499. doi: 10.16766/j.cnki.issn.1674-4152.003667

PDF( 369 KB)

The predictive value of uric acid to albumin ratio for medium and long-term all-cause mortality in patients with CTO

doi: 10.16766/j.cnki.issn.1674-4152.003667

1.
Cardiovascular Department for Gerontism, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230011, China

Funds:

2022AH050770

Received Date: 2024-01-30

Abstract

Abstract

Objective Uric acid to albumin ratio (UAR) can reflect the inflammation and oxidation status, this study was to analyze its expression level in patients with chronic coronary artery occlusion (coronary chronic total occlusion, CTO), and evaluate its prediction value for long-term death in patients. Methods A total of 259 CTO patients undergoing coronary angiography in the Second Affiliated Hospital of Anhui Medical University from January 2019 to March 2023 were selected, and the patients were divided into survival group and death group according to their prognosis. Univariate regression analysis and multivariate logistic regression analysis were used to evaluate the effect of UAR on mortality adverse events in CTO patients. Results Among the 259 CTO patients, 39 (15.06%) died and 220 (84.94%) survived during the follow-up period of approximately of (39.9±12.3) months. Compared with the survival group, patients in the death group exhibited a older age, higher proportion of dual -vessel lesions of CTO, higher levels of blood urea nitrogen, creatinine, uric acid, UAR, and neutrophil-to-lymphocyte ratio (NLR), fewer cases of complete revascularization, and lower levels of albumin and triglycerides (P < 0.05). Multivariate logistic regression analysis showed that the risk factors for poor prognosis in CTO patients include increasing age, increased number of CTO lesions and elevated UAR. The area under the ROC curve for UAR predicting mid to long-term all-cause mortality in CTO patients was 0.648 (95% CI: 0.547-0.748, P=0.003), with a sensitivity of 53.8% and a specificity of 72.7%. Conclusion The UAR of the deceased is significantly higher compared to survivors, indicating that UAR holds certain predictive value for mid to long-term all-cause mortality in patients with chronic total occlusion of the coronary arteries.
- Uric acid to albumin ratio,
- Chronic total occlusion of coronary arteries,
- Regression analysis

FullText(HTML)

References(21)

References

[1]	ALLAHWALA U K, NOUR D, BHATIA K, et al. Prognostic impact of collaterals in patients with a coronary chronic total occlusion: a meta-analysis of over 3, 000 patients[J]. Catheter Cardiovasc Interv, 2021, 97(6): E771-E777.
[2]	OFLAR E, YILDIZ C, KOYUNCU A, et al. Relationship between uric acid albumin ratio and peripheral artery disease complexity[J]. Eur Rev Med Pharmacol Sci, 2023, 27(23): 11472-11478.
[3]	SELÇUK M, ÇINAR T, ŞAYLIK F, et al. Predictive value of uric acid/albumin ratio for the prediction of new-onset atrial fibrillation in patients with ST-elevation myocardial infarction[J]. Rev Invest Clin, 2022, 74(3): 156-164.
[4]	ZHANG Y S, XU Z R, HE W F, et al. Elevated serum uric acid/albumin ratio as a predictor of post-contrast acute kidney injury after percutaneous coronary intervention in patients with ST-Segment elevation myocardial infarction[J]. J Inflamm Res, 2022, 15: 5361-5371. doi: 10.2147/JIR.S377767
[5]	ADALI M K, BUBER I, SEN G, et al. Relationship between systemic immune-inflammation index and coronary collateral circulation in patients with chronic total occlusion[J]. Arq Bras Cardiol, 2022, 119(1): 69-75.
[6]	徐夏莲, 许佳瑞, 王一梅, 等. 术前血尿酸水平对心脏手术术后急性肾损伤发生的影响[J]. 中国临床医学, 2019, 26(3): 450-455. XU X L, XU J R, WANG Y M, et al. Effect of preoperative serum uric acid on the risk of the acute kidney injury after cardiac surgery[J]. Chinese Journal of Clinical Medicine, 2019, 26(3): 450-455.
[7]	李双双, 马依彤, 吴婷婷, 等. 基线血红蛋白水平对老年冠心病患者远期临床预后的影响[J]. 临床内科杂志, 2023, 40(9): 598-602. LI S S, MA Y T, WU T T, et al. Effect of baseline hemoglobin levels on long-term clinical outcome in elderly patients with coronary heart disease[J]. Journal of Clinical Internal Medicine, 2023, 40(9): 598-602.
[8]	YANG Y, ZHANG X Y, JIN Z G, et al. Association of serum uric acid with mortality and cardiovascular outcomes in patients with hypertension: a meta-analysis[J]. J Thromb Thrombolysis, 2021, 52(4): 1084-1093.
[9]	AYOUB M, MASHAYEKHI K, BEHNES M, et al. Prognostic value of different levels of uric acid in patients with coronary chronic total occlusion undergoing percutaneous coronary intervention[J]. J Clin Med, 2023, 12(11): 3794. DOI: 10.3390/jcm12113794.
[10]	CUI K Y, SONG Y J, YIN D, et al. Uric Acid Levels, number of standard modifiable cardiovascular risk factors, and prognosis in patients with coronary artery disease: a large cohort study in Asia[J]. J Am Heart Assoc, 2023, 12(20): e030625. DOI: 10.1161/JAHA.123.030625.
[11]	YAN X J, GONG J, WANG Z W, et al. Serum uric acid was non-linearly associated with the risk of all-cause and cardiovascular death in individuals with coronary heart disease: a large prospective cohort study[J]. Front Endocrinol (Lausanne), 2023, 14: 1278595. DOI: 10.3389/fendo.2023.1278595.
[12]	MANOLIS A A, MANOLIS T A, MELITA H, et al. Low serum albumin: a neglected predictor in patients with cardiovascular disease[J]. Eur J Intern Med, 2022, 102: 24-39.
[13]	BC P K, SOMANNAVAR V G. A study on the role of serum calcium, serum albumin and serum uric acid as markers of initial neurological severity and short term outcome indicators in acute ischemic stroke[J]. J Assoc Physicians India, 2022, 70(4): 11-12.
[14]	康云鹏, 郭雯, 任爱红, 等. 营养风险对老年射血分数减低型心力衰竭患者住院期间体适能的影响[J]. 中华全科医学, 2023, 21(6): 932-935, 944. doi: 10.16766/j.cnki.issn.1674-4152.003018 KANG Y P, GUO W, REN A H, et al. Effect of nutritional risk on physical fitness during hospitalization in elderly patients with reduced ejection fraction heart failure[J]. Chinese Journal of General Practice, 2023, 21(6): 932-935, 944. doi: 10.16766/j.cnki.issn.1674-4152.003018
[15]	BICCIRÉ F G, PASTORI D, TANZILLI A, et al. Low serum albumin levels and in-hospital outcomes in patients with ST segment elevation myocardial infarction[J]. Nutr Metab Cardiovasc Dis, 2021, 31(10): 2904-2911.
[16]	ZOANNI B, BRIOSCHI M, MALLIA A, et al. Novel insights about albumin in cardiovascular diseases: focus on heart failure[J]. Mass Spectrom Rev, 2023, 42(4): 1113-1128.
[17]	YALCINKAYA D, KARACALI K, ILHAN B C, et al. Relation between serum uric acid to albumin ratio and severity of chronic coronary artery disease[J]. Angiology, 2023: 33197231161902. DOI: 10.1177/00033197231161902.
[18]	SULTANA S, K M S, PRAKASH V R, et al. Evaluation of uric acid to albumin ratio as a marker of coronary artery disease severity in acute coronary syndrome: a cross-sectional study[J]. Cureus, 2023, 15(11): e49454. DOI: 10.7759/cureus.49454.
[19]	ŞAYLIK F, ÇINAR T, SARIKAYA R, et al. The association of serum uric acid/albumin ratio with the development of coronary collateral circulation in patients with chronic total occluded coronary arteries[J]. J Cardiovasc Thorac Res, 2023, 15(1): 14-21.
[20]	TOPRAK K, YILMAZ R, KAPLANGORAY M, et al. Comparison of the effect of uric acid/albumin ratio on coronary colleteral circulation with other inflammation-based markers in stable coronary artery disease patients[J]. Perfusion, 2023: 2676591231202105. DOI: 10.1177/02676591231202105.
[21]	KALKAN S, CAGAN EFE S, KARAGÖZ A, et al. A new predictor of mortality in ST-elevation myocardial infarction: the uric acid albumin ratio[J]. Angiology, 2022, 73(5): 461-469.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1) / Tables(3)

Get Citation

PDF

XML

Article Metrics

Article views (21) PDF downloads(3)

The predictive value of uric acid to albumin ratio for medium and long-term all-cause mortality in patients with CTO

doi: 10.16766/j.cnki.issn.1674-4152.003667

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

The predictive value of uric acid to albumin ratio for medium and long-term all-cause mortality in patients with CTO

doi: 10.16766/j.cnki.issn.1674-4152.003667

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content