Volume 22 Issue 9
Sep.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(9): 1533-1537
YE Zhongwei, WU Xuelian, HE Yi. Significance of nutritional status evaluation of BMI combined with hematological indexes in chemotherapy tolerance of patients with advanced digestive tract tumor after operation[J]. Chinese Journal of General Practice, 2024, 22(9): 1533-1537. doi: 10.16766/j.cnki.issn.1674-4152.003676
Citation: YE Zhongwei, WU Xuelian, HE Yi. Significance of nutritional status evaluation of BMI combined with hematological indexes in chemotherapy tolerance of patients with advanced digestive tract tumor after operation[J]. Chinese Journal of General Practice, 2024, 22(9): 1533-1537. doi: 10.16766/j.cnki.issn.1674-4152.003676
shu

Significance of nutritional status evaluation of BMI combined with hematological indexes in chemotherapy tolerance of patients with advanced digestive tract tumor after operation

doi: 10.16766/j.cnki.issn.1674-4152.003676
  • 1.

    Department of Cancer Center, Lishui Central Hospital, Lishui, Zhejiang 323000, China

Funds:

 2023KY1355

  • Received Date: 2023-12-08
    Abstract
  •   Objective  The nutritional status of patients with advanced digestive tract tumours has been demonstrated to affect their tolerance to chemotherapy. Consequently, an accurate evaluation of the nutritional status of patients with advanced digestive tract tumours is conducive to the early identification of high-risk groups with chemotherapy intolerance of advanced digestive tract tumours. Accordingly, the evaluation of nutritional status included the measurement of BMI and hematological indices, with a view to analyzing their value in identifying chemotherapy tolerance in patients with advanced digestive tract tumours was analyzed.  Methods  A total of 255 patients with advanced digestive tract tumours who received chemotherapy at Lishui Central Hospital from August 2021 to January 2023 were divided into a tolerance group and an intolerance group according to their chemotherapy tolerance. Logistic regression was employed to analyze the factors influencing the chemotherapy tolerance of patients with advanced digestive tract tumours, and the receiver operating characteristic (ROC) was constructed to analyze the value of nutritional evaluation of BMI combined with hematological nutritional indicators in predicting chemotherapy tolerance.  Results  A total of 255 patients with advanced digestive tract tumours were included in the study. Of these, 58 patients were intolerant to chemotherapy, while 197 patients were also intolerant to chemotherapy. The results of the logistic regression analysis indicated that age (OR=1.098), BMI (OR=0.550), ALB (OR=0.593), PAB (OR=0.885) and TRF (OR=0.779) were the influencing factors of postoperative chemotherapy tolerance in patients with advanced digestive tract tumours (P < 0.05). Following age adjustment, BMI, ALB, PAB and TRF remain significant influencing factors of chemotherapy tolerance in patients with advanced digestive tract tumours (P < 0.05). The combined use of BMI, ALB, PAB and TRF yielded a C-index of 0.952 for predicting chemotherapy tolerance in patients with advanced digestive tract tumours.  Conclusion  The combination of BMI with hematological nutritional indexes ALB, PAB and TRF can be employed to predict the chemotherapy tolerance of patients with advanced digestive tract tumours following surgical intervention.

     

    • FullText(HTML)
  • loading
    • References(19)
  • [1]
    国家卫生计生委合理用药专家委员会. 消化道恶性肿瘤合理用药指南[J]. 中国合理用药探索, 2017, 14(9): 5-54. doi: 10.3969/j.issn.2096-3327.2017.09.002

    Expert Committee on Rational Drug Use, National Health and Family Planning Commission. Guide of Rational Use of Drug on Malignant Tumors in Digestive Tract[J]. China Licensed Pharmacist, 2017, 14(9): 5-54. doi: 10.3969/j.issn.2096-3327.2017.09.002
    [2]
    IKOMA T, MATSUMOTO T, KURIOKA Y, et al. Improvement of body weight and nutritional status in gastric cancer patients enhances the benefit of nivolumab therapy[J]. J Clin Med, 2022, 11(20): 600.
    [3]
    EOM B W, KOO D H, AN J Y, et al. Prospective multicentre randomised clinical trial comparing survival rates, quality of life and nutritional status between advanced gastric cancer patients with different follow-up intensities: study protocol for the STOFOLUP trial[J]. BMJ Open, 2021, 11(12): e056187. DOI: 10.1136/bmjopen-2021-056187.
    [4]
    李萍, 刘文红, 赵萌, 等. 原发性肝癌肝动脉化疗栓塞术术前营养风险筛查的意义及个体化营养干预效果分析[J]. 中华全科医学, 2021, 19(7): 1087-1090. doi: 10.16766/j.cnki.issn.1674-4152.001991

    LI P, LIU W H, ZHAO M, et al. Significance of nutritional risk screening before transcatheter arterial chemoembolization for primary liver cancer and the effect of individualised nutritional intervention[J]. Chinese Journal of General Practice, 2021, 19(7): 1087-1090. doi: 10.16766/j.cnki.issn.1674-4152.001991
    [5]
    徐令婕. 营养状况对胃癌根治术后患者化疗耐受性和负性情绪的影响研究[D]. 合肥: 安徽医科大学, 2020.

    XU L J. Effect of nutritional status on chemotherapy tolerance and negative emotion in patients with gastric cancer after radical surgery[D]. Hefei: Anhui Medical University, 2020.
    [6]
    中国研究型医院学会消化道肿瘤专业委员会, 中国医师协会外科医师分会多学科综合治疗专业委员会. 消化道肿瘤多学科综合治疗协作组诊疗模式专家共识[J]. 中国实用外科杂志, 2017, 37(1): 30-31.
    [7]
    CLAVIEN P A, BARKUN J, DE OLIVEIRA M L, et al. The Clavien-Dindo classification of surgical complications: five-year experience[J]. Ann Surg, 2009, 250(2): 187-196. doi: 10.1097/SLA.0b013e3181b13ca2
    [8]
    KONDRUP J, RASMUSSEN H H, HAMBERG O, et al. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials[J]. Clin Nutr, 2003, 22(3): 321-336. doi: 10.1016/S0261-5614(02)00214-5
    [9]
    Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2018 (5th edition)[J]. Gastric Cancer, 2021, 24(1): 1-21. doi: 10.1007/s10120-020-01042-y
    [10]
    PAN Y, MA Y, DAI G. The prognostic value of the prognostic nutritional index in patients with advanced or metastatic gastric cancer treated with immunotherapy[J]. Nutrients, 2023, 15(19): 4290. doi: 10.3390/nu15194290
    [11]
    JIN H, ZHU K, WANG W. The predictive values of pretreatment controlling nutritional status (CONUT) score in estimating short- and long-term outcomes for patients with gastric cancer treated with neoadjuvant chemotherapy and curative gastrectomy[J]. J Gastric Cancer, 2021, 21(2): 155-168. doi: 10.5230/jgc.2021.21.e14
    [12]
    YIN C, TOIYAMA Y, OKUGAWA Y, et al. Clinical significance of advanced lung cancer inflammation index, a nutritional and inflammation index, in gastric cancer patients after surgical resection: a propensity score matching analysis[J]. Clin Nutr, 2021, 40(3): 1130-1136. doi: 10.1016/j.clnu.2020.07.018
    [13]
    RYO S, KANDA M, ITO S, et al. The controlling nutritional status score serves as a predictor of short-and long-term outcomes for patients with stage 2 or 3 gastric cancer: analysis of a multi-institutional data set[J]. Ann Surg Oncol, 2019, 26(2): 456-464. doi: 10.1245/s10434-018-07121-w
    [14]
    CHANTHARAKHIT C, SUJARTVANICHPONG N, CHANTHARAKHIT C. Prognostic value of the pre-treatment prognostic nutritional index for patients with unresectable locally-advanced and advanced stage upper gastrointestinal tract cancer[J]. Int J Gen Med, 2022, 15(1): 6681-6689.
    [15]
    LEE J, CHOI S H, BAEK J H, et al. Clinical impact of prognostic nutrition index for advanced gastric cancer patients with peritoneal metastases treated nivolumab monotherapy[J]. Chonnam Med J, 2022, 58(1): 24-28. doi: 10.4068/cmj.2022.58.1.24
    [16]
    MIZUKAMI T, MIYAJI T, NARITA Y, et al. An observational study on nutrition status in gastric cancer patients receiving ramucirumab plus taxane: BALAST study[J]. Future Oncol, 2021, 17(19): 2431-2438. doi: 10.2217/fon-2021-0076
    [17]
    SUN W, LI G, ZHNAG J, et al. The role of nutritional assessment for predicting radiotherapy-induced adverse events in patients with gastric cancer[J]. Br J Radiol, 2022, 95(1130): 20201004. DOI: 10.1259/bjr.20201004.
    [18]
    XU R, CHEN X D, DING Z. Perioperative nutrition management for gastric cancer[J]. Nutrition, 2022, 93: 111492. DOI: 10.1016/j.nut.2021.111492.
    [19]
    MENG Q, TAN S, JIANG Y, et al. Post-discharge oral nutritional supplements with dietary advice in patients at nutritional risk after surgery for gastric cancer: a randomized clinical trial[J]. Clin Nutr, 2020, 4(1): 43.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(2)  / Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (23) PDF downloads(2) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return