Volume 22 Issue 10
Oct.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(10): 1671-1674
LIU Jia, CUI Zhen, SUN Qiaoyu, CHANG Fangfang. Effect of radiotherapy dose on prognosis of cervical esophageal squamous cell carcinoma after define concurrent chemoradiotherapy[J]. Chinese Journal of General Practice, 2024, 22(10): 1671-1674. doi: 10.16766/j.cnki.issn.1674-4152.003708
Citation: LIU Jia, CUI Zhen, SUN Qiaoyu, CHANG Fangfang. Effect of radiotherapy dose on prognosis of cervical esophageal squamous cell carcinoma after define concurrent chemoradiotherapy[J]. Chinese Journal of General Practice, 2024, 22(10): 1671-1674. doi: 10.16766/j.cnki.issn.1674-4152.003708
shu

Effect of radiotherapy dose on prognosis of cervical esophageal squamous cell carcinoma after define concurrent chemoradiotherapy

doi: 10.16766/j.cnki.issn.1674-4152.003708

  • Department of Radiotherapy, the First Affliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 2022AH051446

 卫科教秘[2018]291号

  • Received Date: 2023-11-18
    Available Online: 2024-12-28
    Abstract
  •   Objective   The dose of define concurrent chemoradiotherapy for cervical esophageal squamous cell carcinoma(CEC) is controversial. This study analyzed the efficacy of patients with CEC who received define concurrent chemoradiotherapy, hoping to provide a clinical reference for the dose of radiotherapy for CEC.   Methods   A retrospective analysis was performed on 89 patients with CEC who received intensity-modulated radiotherapy (IMRT) in the Department of Radiotherapy, the First Affiliated Hospital of Bengbu Medical University from January 2013 to December 2021 and were divided into two groups according to radiotherapy dose: a low-dose group (EQD2Gy≤60 Gy) and a high-dose group (EQD2Gy>60 Gy). Chemotherapy regimens include platinum-based dual drug combination or S1 alone. The Kaplan-Meier method was used to calculate loco-regional control (LRC), progression-free survival (PFS), and overall survival (OS). The log-rank method was used to test differences and univariate analysis. The Cox model was used to analyze prognostic factors.   Results   The follow-up rate was 100% and the median follow-up time was 100 months. The 1-year, 3-year, and 5-year LRC rates were 76.1%, 37.9%, and 22.4%, respectively, and the PFS rates were 67.4%, 30.0%, and 16.2%, respectively. The OS rates were 85.4%, 47.1%, and 29.6%, respectively. Univariate analysis showed that T stage, N stage, TNM stage, and radiotherapy dose were the influencing factors of OS, PFS, and LRC, and radiotherapy dose was the independent prognostic factor of 0S, PFS, and LRC in cervical esophageal squamous cell carcinoma (P < 0.05).   Conclusion   When cervical esophageal squamous cell carcinoma is treated with define chemoradiotherapy, EQD2Gy>60 Gy showed a better survival benefit, and radiotherapy dose was an independent prognostic factor for OS, PFS, and LRC.

     

    • FullText(HTML)
  • loading
    • References(17)
  • [1]
    SUNG H, FERLAY J, SIEGEL R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. doi: 10.3322/caac.21660
    [2]
    LUO H S, HUANG H C, LIN L X. Effect of modern high-dose versus standard-dose radiation in definitive concurrent chemo-radiotherapy on outcome of esophageal squamous cell cancer: a meta-analysis[J]. Radiat Oncol, 2019, 14(1): 178. doi: 10.1186/s13014-019-1386-x
    [3]
    赵丹, 郑宝敏, 肖绍文, 等. 颈段食管癌放疗患者复发模式及生存分析[J]. 中华放射医学与防护杂志, 2019, 39(1): 44-50.

    ZHAO D, ZHENG B M, XIAO S W, et al. Recurrence pattern and survival of patients with cervical esophageal cancer treated with radiotherapy[J]. Chinese Journal of Radiology and Protection, 2019, 39(1): 44-50.
    [4]
    夏祥伟. 颈段食管癌根治性同步放化疗疗效及预后因素分析[J]. 临床医药文献电子杂志, 2019, 6(92): 71-73.

    XIA X W. Analysis of curative effect and prognostic factors of radical radiotherapy and chemotherapy for cervical esophageal cancer[J]. Journal of Clinical Medical Literature Electronic, 2019, 6(92): 71-73.
    [5]
    INADA M, NISHIMURA Y, ISHIKAWA K, et al. Outcome of chemoradiotherapy using intensity-modulated radiation therapy for cervical esophageal cancer: a single institute experience[J]. Esophagus, 2021, 18(3): 638-644. doi: 10.1007/s10388-020-00812-y
    [6]
    WANG J, WU Y, ZHANG W, et al. Elective nodal irradiation versus involved-field irradiation for stage Ⅱ-Ⅳ cervical esophageal squamous cell carcinoma patients undergoing definitive concurrent chemoradiotherapy: a retrospective propensity study with 8-year survival outcomes[J]. Radiat Oncol, 2023, 18(1): 142. doi: 10.1186/s13014-023-02332-2
    [7]
    王桂峰, 崔珍, 万强琨, 等. 老年食管鳞癌根治性同步放化疗后替吉奥辅助化疗的疗效观察与预后因素分析[J]. 中华全科医学, 2021, 19(3): 379-382. doi: 10.16766/j.cnki.issn.1674-4152.001815

    WANG G F, CUI Z, WAN Q K, et al. Observation of curative effect and prognostic factors of Teggio adjuvant chemotherapy in elderly patients with esophageal squamous cell carcinoma after radical concurrent radiotherapy and chemotherapy[J]. Chinese Journal of General Practice, 2021, 19(3): 379-382. doi: 10.16766/j.cnki.issn.1674-4152.001815
    [8]
    杨健筌, 郭文, 郎锦义, 等. 同步放疗联合替吉奥对比单纯放疗治疗老年食管癌Meta分析[J]. 中华放射肿瘤学杂志, 2022, 31(9): 791-797.

    YANG J Q, GUO W, LANG J Y, et al. Meta-analysis of simultaneous radiotherapy combined with S-1 in the treatment of elderly patients with esophageal cancer[J]. Chinese Journal of Radiation Oncology, 2022, 31(9): 791-797.
    [9]
    ZHOU X L, YU C H, WANG W W, et al. Concurrent chemoradiotherapy with S-1 compared with concurrent chemoradiotherapy with docetaxel and cisplatin for locally advanced esophageal squamous cell carcinoma[J]. Radiat Oncol, 2021, 16(1): 94. doi: 10.1186/s13014-021-01821-6
    [10]
    沈文斌, 高红梅, 许金蕊, 等. 颈胸上段食管癌根治性调强放疗±化疗后无复发生存初步分析[J]. 中华放射肿瘤学杂志, 2022, 31(2): 143-148.

    SHEN W B, GAO H M, XU J R, et al. Preliminary analysis of relapse-free survival after radical intensity modulated radiotherapy plus or minus chemotherapy for upper cervical and thoracic esophageal cancer[J]. Chinese Journal of Radiation Oncology, 2022, 31(2): 143-148.
    [11]
    赵晶晶, 庞青松, 王平. 食管癌根治性放疗剂量研究进展[J]. 中华放射肿瘤学杂志, 2020, 29(7): 589-592.

    ZHAO J J, PANG Q S, WANG P. Research progress of radical radiotherapy dose for esophageal cancer[J]. Chinese Journal of Radiation Oncology, 2020, 29(7): 589-592.
    [12]
    冯活林, 肖剑, 黄锡英, 等. 影响颈段食管癌放疗患者预后的相关因素分析[J]. 临床医学研究与实践, 2022, 7(19): 32-34.

    FENG H L, XIAO J, HUANG X Y, et al. Analysis of related factors affecting prognosis of patients with cervical esophageal cancer treated with radiotherapy[J]. Clinical Medicine Research and Practice, 2022, 7(19): 32-34.
    [13]
    ZHANG J, ZHANG W, ZHANG B, et al. Clinical results of intensity-modulated radiotherapy for 250 patients with cervical and upper thoracic esophageal carcinoma[J]. Cancer Manag Res, 2019, 11: 8285-8294. doi: 10.2147/CMAR.S203575
    [14]
    LI C C, CHEN C Y, CHOU Y H, et al. Optimal radiotherapy dose in cervical esophageal squamous cell carcinoma patients treated with definitive concurrent chemoradiotherapy: a population based study[J]. Thorac Cancer, 2021, 12(14): 2065-2071. doi: 10.1111/1759-7714.14009
    [15]
    CHEN Y H, LU H, LO C M, et al. The clinical outcomes of locally advanced cervical esophageal squamous cell carcinoma patients receiving curative concurrent chemoradiotherapy: a population-based propensity score-matched analysis[J]. Cancers, 2019, 11(4): 1-12.
    [16]
    KWONG D L W, CHAN W W L, LAM K O. Radiotherapy for cervical esophageal squamous cell carcinoma[J]. Methods Mol Biol, 2020: 295-305. DOI: 10.1007/978-1-0716-0377-2_22.
    [17]
    刘璇, 罗京伟, 周宗玫, 等. 颈段食管癌根治性放疗的长期疗效及失败模式分析[J]. 中华肿瘤杂志, 2022, 44(10): 1125-1131.

    LIU X, LUO J W, ZHOU Z M, et al. Long-term efficacy and failure mode analysis of radical radiotherapy for cervical esophageal cancer[J]. Chinese Journal of Oncology, 2022, 44(10): 1125-1131.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(4)  / Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (24) PDF downloads(2) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return