Volume 22 Issue 10
Oct.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(10): 1705-1708
LAN Shaobo, ZHOU Mi, WU Xinjuan, SHAO Jiawei. Effect of Zishuihanmu prescription combined with polyene phosphatidylcholine on immune function in patients with chronic hepatitis B cirrhosis[J]. Chinese Journal of General Practice, 2024, 22(10): 1705-1708. doi: 10.16766/j.cnki.issn.1674-4152.003716
Citation: LAN Shaobo, ZHOU Mi, WU Xinjuan, SHAO Jiawei. Effect of Zishuihanmu prescription combined with polyene phosphatidylcholine on immune function in patients with chronic hepatitis B cirrhosis[J]. Chinese Journal of General Practice, 2024, 22(10): 1705-1708. doi: 10.16766/j.cnki.issn.1674-4152.003716
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Effect of Zishuihanmu prescription combined with polyene phosphatidylcholine on immune function in patients with chronic hepatitis B cirrhosis

doi: 10.16766/j.cnki.issn.1674-4152.003716

  • Department of Infectious Liver Disease, Affiliated Hospital of Shaoxing University of Arts and Sciences, Shaoxing, Zhejiang 312000, China

Funds:

 2022ZA175

  • Received Date: 2024-04-28
    Available Online: 2024-12-28
    Abstract
  •   Objective  To evaluated the clinical efficacy of Zishuhanmu prescription combined with polyene phosphatidylcholine in treating patients with chronic hepatitis B cirrhosis by observing the changes in liver function, liver fibrosis, inflammatory response, oxidative stress, immune function, and other indicators of patients.  Methods  A total of 100 patients with chronic hepatitis B cirrhosis, admitted to the Affiliated Hospital of Shaoxing University of Arts and Sciences from March 2021 to March 2024, were selected and divided into a control group and a combination group, with 50 patients in each group by random number table method. The control group was treated with polyene phosphatidylcholine, and the combination group was treated with Zishuihanmu prescription combined with polyene phosphatidylcholine. Traditional chinese medicine (TCM) syndrome scores were compared between the two groups, liver function, liver fibrosis index levels, and serum levels of total antioxidant capacity (TAOC), advanced oxidation protein products (AOPP), hypersensitivity C-reactive protein (hs-CRP) and TNF-α were also compared between the two groups. CD4+ and CD3+ levels were detected by flow cytometry, and the therapeutic effects of the two groups were compared.  Results  After treatment, the TCM syndrome score of the combination group was lower than that of the control group (P < 0.05). The indexes of liver function and liver fibrosis in the combination group were lower than those in the control group (P < 0.05). Additionally, the levels of TAOC, AOPP, hs-CRP, and TNF-α in the combination group were lower than those in the control group (P < 0.05). The CD4+ and CD3+ levels in the combination group were 42.63±4.89 and 68.57±6.87, respectively, which were higher than those in the control group (39.41±3.75 and 64.21±6.32, P < 0.05). The effective treatment rate of the combination group was 94.00%, 47/50, higher than that in the control group (80.00%, 40/50, P < 0.05).  Conclusion  The combination of Zishuihanmu prescription and polyene phosphatidylcholine in the treatment of chronic hepatitis B cirrhosis patients can reduce severity of TCM syndromes, improve liver function and liver fibrosis, alleviate oxidative stress and inflammatory reaction, and enhance immune function, resulting a notable therapeutic effect.

     

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