Volume 22 Issue 10
Oct.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(10): 1718-1721
FANG Haiying, ZHANG Linqian. The value of gastric juice and peripheral blood total bile acids in the diagnosis of bile reflux gastritis in children[J]. Chinese Journal of General Practice, 2024, 22(10): 1718-1721. doi: 10.16766/j.cnki.issn.1674-4152.003719
Citation: FANG Haiying, ZHANG Linqian. The value of gastric juice and peripheral blood total bile acids in the diagnosis of bile reflux gastritis in children[J]. Chinese Journal of General Practice, 2024, 22(10): 1718-1721. doi: 10.16766/j.cnki.issn.1674-4152.003719
shu

The value of gastric juice and peripheral blood total bile acids in the diagnosis of bile reflux gastritis in children

doi: 10.16766/j.cnki.issn.1674-4152.003719
  • 1.

    Department of Paediatrics, Jinhua Maternal and Child Health Hospital, Jinhua, Zhejiang 321000, China

Funds:

 2022RC288

  • Received Date: 2024-01-17
    Abstract
  •   Objective  To investigate the expression of total bile acid (TBA) in gastric juice and peripheral blood in children with bile reflux gastritis (BRG) and its diagnostic value.  Methods  The clinical data of 120 children with BRG diagnosed and treated in Jinhua Maternal and Child Health Care Hospital from May 2021 to June 2023 were retrospectively analyzed. The BRG children were set as the observation group, and 59 healthy children were selected as the control group during the same period. The gastric fluid and peripheral blood TBA were compared. Kendall ' s tau-b method was used to analyze the correlation between gastric fluid and peripheral blood TBA and the clinical characteristics of BRG children. Receiver operating characteristic (ROC) curve was drawn to analyze the AUC value, sensitivity and specificity of TBA diagnosis of BRG.  Results  The TBA of gastric juice and peripheral blood in the observation group were [(13.55±4.74) μmol/L and (11.24±3.04) μmol/L], respectively, which were higher than those in the control group [(8.08±1.83) μmol/L and (7.71±2.05) μmol/L, P < 0.05]. There were statistically significant differences in TBA in gastric juice and peripheral blood among different Helicobacter pylori infection, intestinal metaplasia, lymphoid follicular hyperplasia, gastric fovea hyperplasia and mucosal superficial vasodilation (P < 0.05). Kendall ' s tau-b correlation analysis showed that gastric fluid and peripheral blood TBA were positively correlated with Helicobacter pylori infection, intestinal metaplasia, lymphofollicular hyperplasia, gastric fovea hyperplasia, mucosal superficial vasodilation, and total bile reflux (P < 0.05). ROC curve analysis showed that the AUC values of TBA in gastric juice and peripheral blood were 0.872 and 0.780, respectively. The sensitivity were 90.80% and 50.00%. The specificity were 69.50% and 96.60%.  Conclusion  The expression of TBA in gastric juice and peripheral blood is abnormal in BRG children, and the observation of its expression is helpful to provide guidance for clinical diagnosis.

     

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