Volume 22 Issue 10
Oct.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(10): 1746-1749
BIAN Guifeng, LI Xiaodong, HE Song, ZHANG Bin, LI Jiaojiao. The predictive value of MRI-DWI-IVIM multiparameter imaging in tumor infiltrating lymphocyte levels after neoadjuvant chemotherapy for invasive breast cancer[J]. Chinese Journal of General Practice, 2024, 22(10): 1746-1749. doi: 10.16766/j.cnki.issn.1674-4152.003725
Citation: BIAN Guifeng, LI Xiaodong, HE Song, ZHANG Bin, LI Jiaojiao. The predictive value of MRI-DWI-IVIM multiparameter imaging in tumor infiltrating lymphocyte levels after neoadjuvant chemotherapy for invasive breast cancer[J]. Chinese Journal of General Practice, 2024, 22(10): 1746-1749. doi: 10.16766/j.cnki.issn.1674-4152.003725
shu

The predictive value of MRI-DWI-IVIM multiparameter imaging in tumor infiltrating lymphocyte levels after neoadjuvant chemotherapy for invasive breast cancer

doi: 10.16766/j.cnki.issn.1674-4152.003725
  • 1.

    Department of Nuclear Magnetic Resonance, the First Affiliated Hospital of Hebei Northern University, Zhangjiakou, Hebei 075000, China

Funds:

 20210136

  • Received Date: 2024-02-03
    Available Online: 2024-12-28
    Abstract
  •   Objective   To investigate the potential of magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) and intravoxel incoherence motion (IVIM) multiparameter imaging in predicting tumour infiltrating lymphocyte (TILs) levels in patients with invasive breast cancer who have undergone neoadjuvant chemotherapy.   Methods   A total of 140 patients with invasive breast cancer admitted to the hospital between December 2021 and December 2022 were selected as the study subjects. All patients underwent an MRI-DWI-IVIM examination, received neoadjuvant chemotherapy, and had their TILs evaluated after treatment. The utility of MRI-DWI-IVIM multiparameter imaging in predicting TIL levels was evaluated.   Results   The positive rate of TILs after treatment (80.71%) was significantly higher than that before treatment (63.57%, χ2=10.236, P < 0.05). Furthermore, there was a statistically significant difference in the boundary, T2WI signal and DWI signal between TILs positive and TILs negative patients (P < 0.05). The pseudo-diffusion coefficient (D*) of TILs-positive patients was observed to be lower than that of TILs-negative patients, while the simple diffusion coefficient (D) and microvascular volume fraction (f) were found to be higher than those of TILs-negative patients (P < 0.05). Receiver operating characteristic curves demonstrated that the area under the curve (AUC) predicted by the boundary, T2WI signal, DWI signal, D*, D and f on TILs were 0.640, 0.610, 0.640, 0.866, 0.720 and 0.674, respectively. Furthermore, the combined AUC of all indicators was 0.948.   Conclusion   The level of TILs was observed to increase following the administration of neoadjuvant chemotherapy for invasive breast cancer. Multiparameter imaging by MRI-DWI-IVIM can be used to evaluate the level of TILs after chemotherapy. Furthermore, the combination of all indicators can improve the predictive value of the TILs level.

     

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