Study of the relationship between serum sCD14, HMGB1 levels and cross-infection in orthodontic patients

FANG Min; ZOU Ying; CHENG Chun; WANG Qing; MI Congbo

doi:10.16766/j.cnki.issn.1674-4152.003744

Volume 22 Issue 11

Nov. 2024

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Article Navigation > Chinese Journal of General Practice > 2024 > 22(11): 1833-1836

FANG Min, ZOU Ying, CHENG Chun, WANG Qing, MI Congbo. Study of the relationship between serum sCD14, HMGB1 levels and cross-infection in orthodontic patients[J]. Chinese Journal of General Practice, 2024, 22(11): 1833-1836. doi: 10.16766/j.cnki.issn.1674-4152.003744

Citation:

FANG Min, ZOU Ying, CHENG Chun, WANG Qing, MI Congbo. Study of the relationship between serum sCD14, HMGB1 levels and cross-infection in orthodontic patients[J]. Chinese Journal of General Practice, 2024, 22(11): 1833-1836. doi: 10.16766/j.cnki.issn.1674-4152.003744

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Study of the relationship between serum sCD14, HMGB1 levels and cross-infection in orthodontic patients

doi: 10.16766/j.cnki.issn.1674-4152.003744

Department of Orthodontics, the First Affiliated Hospital of Xinjiang Medical University/Affiliated Stomatological Hospital, Urumqi, Xinjiang 830000, China

Funds:

8196030305

Received Date: 2024-04-11
Available Online: 2024-12-31

Abstract

Abstract

Objective To investigate the relationship between serum soluble cluster of differentiation antigen 14 (sCD14) and high mobility group B1 (HMGB1) levels and the occurrence of cross-infection in orthodontic patients, as well as their predictive value for cross-infection. Methods A total of 183 orthodontic patients admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2018 to January 2022 were taken as the study object. Among them, 93 cases with cross-infection during orthodontic treatment were taken as the infection group, while 90 cases without cross-infection were taken as the control group. The levels of serum sCD14 and HMGB1 were detected by enzyme-linked immunosorbent assay (ELISA). Multivariate logistic regression was used to analyze the influencing factors of cross-infection, and the relationship between sCD14, HMGB1, and cross infection in orthodontic patients was analyzed by ROC curves. Results Compared with the control group, the levels of serum sCD14 and HMGB1 in the infection group were obviously higher (P < 0.05). Elevated levels of serum sCD14 and HMGB1 were independent risk factors for cross-infection in orthodontic patients (P < 0.05). The area under the curve (AUC) for predicting cross-infection was 0.769 for sCD14 and 0.783 for HMGB1. The combined AUC of both markers was 0.886, significantly higher than that for either marker alone (P < 0.001). Conclusion Increased serum levels of sCD14 and HMGB1 are increased with cross-infection in orthodontic patients, and their combined detection offers strong predictive value for the occurrence of cross-infection.
- Serum soluble CD14,
- High mobility group protein B1,
- Orthodontics,
- Cross infection

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References(22)

References

[1]	MAZGAEEN L, GURUNG P. Recent advances in lipopolysaccharide recognition systems[J]. Int J Mol Sci, 2020, 21(2): 379-396. doi: 10.3390/ijms21020379
[2]	ADEKOYA M N, ADEYEMI T E, AIKINS E A. COVID-19 risks and extra-protective measures practised among Nigerian orthodontists and orthodontic residents[J]. Niger Postgrad Med J, 2021, 28(2): 88-93. doi: 10.4103/npmj.npmj_576_21
[3]	FU Y J, XU B, HUANG S W, et al. Baicalin prevents LPS-induced activation of TLR4/NF-kB p65 pathway and inflammation in mice via inhibiting the expression of CD14[J]. Acta Pharmacol Sin, 2021, 42(1): 88-96. doi: 10.1038/s41401-020-0411-9
[4]	XUE J M, SUAREZ J S, MINAAI M, et al. HMGB1 as a therapeutic target in disease[J]. J Cell Physiol, 2021, 236(5): 3406-3419. doi: 10.1002/jcp.30125
[5]	WANG S M, ZHANG Y. HMGB1 in inflammation and cancer[J]. J Hematol Oncol, 2020, 24, 13(1): 116-120.
[6]	CAI X F, BISWAS I, PANICKER S R, et al. Activated protein C inhibits lipopolysaccharide-mediated acetylation and secretion of high-mobility group box1 in endothelial cells[J]. J Thromb Haemost, 2019, 17(5): 803-817. doi: 10.1111/jth.14425
[7]	黄芸, 徐宇红. 口腔正畸中牙槽骨高度的研究进展[J]. 新医学, 2020, 51(12): 907-910. HUANG Y, XU Y H. Research progress on alveolar bone height in orthodontics[J]. Journal of New Medicine, 2020, 51(12): 907-910.
[8]	宋生璋, 程楚昕, 阎转君. 老年口腔正畸感染者病原学分布及相关影响因素分析[J]. 实用老年医学, 2020, 34(3): 266-269. SONG S Z, CHENG C X, YAN Z J. Analysis of etiology distribution and related influencing factors in elderly patients with orthodontic infection[J]. Practical Geriatrics, 2020, 34(3): 266-269.
[9]	张智轶, 安峰, 卢成, 等. 正畸治疗中发生口腔伤口感染的相关危险因素及病原学分析[J]. 中国美容医学, 2021, 30(6): 146-150. ZHANG Z Y, AN F, LU C, et al. Related risk Factors and Etiology Analysis of Oral Wound Infection During Orthodontics[J]. Chinese Journal of Aesthetic Medicine, 2021, 30(6): 146-150.
[10]	CHENG H C, YEN Y C, MING-FANG YEN A, et al. Factors affecting infection control measures performed by dental workers[J]. J Dent Sci, 2023, 18(2): 722-729. doi: 10.1016/j.jds.2022.11.023
[11]	SHI S, ZHENG H C, ZHANG Z G. Roles of Fascin mRNA expression in colorectal cancer: meta-analysis and bioinformatics analysis[J]. Mol Clin Oncol, 2020, 13(2): 119-128. doi: 10.3892/mco.2020.2069
[12]	朱利娟, 张立娜. 青少年口腔正畸中微型种植体支抗的应用效果及对骨桥蛋白Fascin蛋白水平的影响[J]. 中国药物与临床, 2021, 21(7): 1120-1122. ZHU L J, ZHANG L N. Effectiveness of the application of miniature implant supports in adolescent orthodontics and the effect on the level of Fascin protein, a bone bridging protein[J]. Chinese Remedies & Clinics, 2021, 21(7): 1120-1122.
[13]	KOFFI K A, DOUBLIER S, RICORT J M, et al. The role of GH/IGF axis in dento-alveolar complex from development to aging and therapeutics: a narrative review[J]. Cells, 2021, 10(5): 1181. DOI: 10.3390/cells10051181.
[14]	ALMALKI A, THOMAS J T, ALOTAIBI S, et al. Association between chronological age and IGF-1, IGFBP-3, and CTX levels in saliva of children through younger adult population with varying periodontal status[J]. Children (Basel), 2022, 9(9): 1301-1312.
[15]	MALDEGHEM I V, NUSMAN C M, VISSER D H. Soluble CD14 subtype (sCD14-ST) as biomarker in neonatal early-onset sepsis and late-onset sepsis: a systematic review and meta-analysis[J]. BMC Immunol, 2019, 20(1): 17. DOI: 10.1186/s12865-019-0298-8.
[16]	GÓMEZ-RIAL J, CURRÁS-TUALA M J, RIVERO-CALLE I, et al. Increased serum levels of sCD14 and sCD163 indicate a preponderant role for monocytes in COVID-19 immunopathology[J]. Front Immunol, 2020, 11(1): 560381. DOI: 10.3389/fimmu.2020.560381.
[17]	YANG K, PAN Y, YAN B, et al. Serum sCD14 as a biomarker for significant liver inflammation in chronic hepatitis B patients with normal or mildly elevated ALT[J]. Clin Lab, 2021, 67(10). DOI: 10.7754/Clin.Lab.2021.210130.
[18]	WATANABE M, TOYOMURA T, WAKE H, et al. Cationic ribosomal proteins can inhibit pro-inflammatory action stimulated by LPS+HMGB1 and are hindered by advanced glycation end products[J]. Biotechnol Appl Biochem, 2024, 71(2): 264-271. doi: 10.1002/bab.2538
[19]	FENG Y P, HU S Y, LIU L, et al. HMGB1 contributes to osteoarthritis of temporomandibular joint by inducing synovial angiogenesis[J]. J Oral Rehabil, 2021, 48(5): 551-559. doi: 10.1111/joor.13129
[20]	ZHANG T, WU K Y, MA N, et al. The C5a/C5aR2 axis promotes renal inflammation and tissue damage[J]. JCI Insight, 2020, 5(7): e134081. DOI: 10.1172/jci.insight.134081.
[21]	LAI W X, LI X Y, KONG Q, et al. Extracellular HMGB1 interacts with RAGE and promotes chemoresistance in acute leukemia cells[J]. Cancer Cell Int, 2021, 21(1): 700-720. doi: 10.1186/s12935-021-02387-9
[22]	胡慧婷, 袁静芝, 史清海, 等. 血清sCD14, HMGB1联合检测在肺部感染疾病中的临床诊断价值[J]. 国际检验医学杂志, 2020, 41(3): 270-273. HU H T, YUAN J Z, SHI Q H, et al. Clinical diagnostic value of combined detection of serum sCD14 and HMGB1 in pulmonary infection[J]. International Journal of Laboratory Medicine, 2020, 41(3): 270-273.