Volume 22 Issue 11
Nov.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(11): 1863-1867
SUN Aolong, ZHANG Like, XU Quanxiao, WEN Xin, LI Weiyang. The expression of GZMB and PD-L1 and their relationship with prognosis in non-small cell lung patients[J]. Chinese Journal of General Practice, 2024, 22(11): 1863-1867. doi: 10.16766/j.cnki.issn.1674-4152.003751
Citation: SUN Aolong, ZHANG Like, XU Quanxiao, WEN Xin, LI Weiyang. The expression of GZMB and PD-L1 and their relationship with prognosis in non-small cell lung patients[J]. Chinese Journal of General Practice, 2024, 22(11): 1863-1867. doi: 10.16766/j.cnki.issn.1674-4152.003751
shu

The expression of GZMB and PD-L1 and their relationship with prognosis in non-small cell lung patients

doi: 10.16766/j.cnki.issn.1674-4152.003751
  • 1.

    Respiratory and Critical Care Medicine, the First People's Hospital of Nanyang City Affiliated to Xinxiang Medical College, Nanyang, Henan 473010, China

Funds:

 LHGJ20200903

 23KJGG215

  • Received Date: 2023-12-12
    Available Online: 2024-12-31
    Abstract
  •   Objective  To analyze the expression and clinical significance of granzyme B (GZMB) and programmed cell death ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC).  Methods  Tumor and tumor-adjacent tissues were collected in 105 NSCLC patients from January 2015 to December 2019, and the expressions of GZMB and PD-L1 were detected to analyze the relationship between GZMB expression and clinicopathological features of NSCLC patients by immunohistochemistry. Thirty fresh NSCLC tissues collected from the First People's Hospital of Nanyang between March 2023 and August 2023, RT-qPCR was used to detect the relative expression levels of GZMB and PD-L1mRNA. GZMB and PD-L1 expression were performed by Spearman correlation analysis. Kaplan-Meier curve was drawn for survival analysis, and Cox regression was used to analyze the influencing factors of prognosis.  Results  There was no difference in the expression levels of GZMB between tumor and adjacent tissues in NSCLC patients (P>0.05), and PD-L1 was highly expressed in cancer tissues compared with para-cancer tissues (P < 0.001). Spearman correlation analysis revealed a negative correlation between GZMB expression and PD-L1 expression in NSCLC tissues (r=-0.448, P < 0.001). And showed a negative correlation between the relative mRNA expression levels of GZMB and PD-L1 in fresh NSCLC tissues (r=-0.846, P < 0.001). The expression of GZMB was related to the depth of invasion, lymph node metastasis, and distant metastasis of NSCLC. The median survival time of 105 patients with NSCLC was 39.36 months (1-100 months), the survival time of patients with high expression of GZMB (59.15 months) was higher than that of patients with low expression (19.70 months), and the survival time of patients with high expression of PD-L1 (26.67 months) was lower than that of patients with low expression (50.46 months). Cox regression analysis showed that GZMB and PD-L1 were independent factors affecting the prognosis of NSCLC patients (P < 0.001).  Conclusion  In NSCLC patients, there is a negative correlation between the expression of GZMB and PD-L1. High expression of GZMB is an independent protective factor for good prognosis in patients, while high expression of PD-L1 is an independent risk factor for poor prognosis in patients.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    关月, 张跃, 时洪洋, 等. 非小细胞肺癌精准治疗疗效影响因素的研究进展[J]. 癌症进展, 2023, 21(5): 468-472, 507.

    GUAN Y, ZHANG Y, SHI H Y, et al. Research progress on influencing factors of precise treatment for non-small cell lung cancer[J]. Oncology Progress, 2023, 21(5): 468-472, 507.
    [2]
    黄庭, 贡会源, 唐震, 等. KLHL7在非小细胞肺癌中的表达及其临床意义[J]. 中华全科医学, 2023, 21(7): 1109-1112, 1219. doi: 10.16766/j.cnki.issn.1674-4152.003061

    HUANG T, GONG H Y, TANG Z, et al. Expression of KLHL7 in non-small cell lung cancer and its clinical significance[J]. Chinese Journal of General Practice, 2023, 21(7): 1109-1112. doi: 10.16766/j.cnki.issn.1674-4152.003061
    [3]
    谢忠海, 李鸿伟, 臧金, 等. 非小细胞肺癌根治术患者术后临床特征调查及预后影响因素分析[J]. 中华全科医学, 2022, 20(11): 1860-1862. doi: 10.16766/j.cnki.issn.1674-4152.002720

    XIE Z H, LI H W, ZANG J, et al. Investigation of clinical characteristics and prognostic factors in patients with non-small cell lung cancer after radical resection[J]. Chinese Journal of General Practice, 2022, 20(11): 1860-1862. doi: 10.16766/j.cnki.issn.1674-4152.002720
    [4]
    田海英, 张东旸, 徐荣建, 等. TRIM59在非小细胞肺癌中的表达及其与预后的关系[J]. 中国肺癌杂志, 2020, 23(1): 21-28.

    TIAN H Y, ZHANG D C, HAN Y D, et al. Expression of TRIM59 in non-small cell lung cancer and its correlation with prognosis[J]. Chinese Journal of Lung Cancer, 2020, 23(1): 21-28.
    [5]
    LIANG Q, ZHANG H. MAP17 contributes to non-small cell lung cancer progression via suppressing miR-27a-3p expression and p38 signaling pathway[J]. Cancer Biol Ther, 2021, 22(1): 19-29. doi: 10.1080/15384047.2020.1836948
    [6]
    DU T T, GAO Q L, ZHAO Y H, et al. Long non-coding RNA LINC02474 affects metastasis and apoptosis of colorectal cancer by inhibiting the expression of GZMB[J]. Front Oncol, 2021, 9(11): 651796. DOI: 10.3389/fonc.2021.651796.
    [7]
    徐尚尚, 刘天奇. 颗粒酶B在肿瘤诊治中的研究进展[J]. 中南药学, 2023, 21(3): 742-745.

    XU S S, LIU T Q. Research progress of granzyme B in the diagnosis and treatment of tumor[J]. Central South Pharmacy, 2023, 21(3): 742-745.
    [8]
    袁杭, 王声燕, 倪亨吏, 等. PD-L1在头颈部高分化鳞状细胞癌中的表达模式及临床病理学意义[J]. 现代肿瘤医学, 2023, 31(20): 3776-3780.

    YUAN H, WANG S Y, ZENG H, et al. Expression pattern and clinicopathological significance of PD-L1 in highly differentiated head and neck squamous cell carcinoma[J]. Journal of Modern Oncology, 2023, 31(20): 3776-3780.
    [9]
    刘俊英, 杨会钗, 李诗, 等. 肺腺癌中CALHM2、PD-L1的表达及其预后分析[J]. 临床与实验病理学杂志, 2023, 39(8): 957-962.

    LIU J Y, YANG H C, LIU Y P, et al. Expression of CALHM2 and PD-L1 and prognostic analysis in lung adenocarcinoma[J]. Chinese Journal of Clinical and Experimental Pathology, 2023, 39(8): 957-962.
    [10]
    张媛媛, 马静, 何会娜, 等. 非小细胞肺癌组织中Notch1、PTEN表达相关性及其与患者预后的关系[J]. 山东医药, 2022, 62(29): 58-61.

    ZHANG Y Y, MA J, CHI F, et al. The correlation between Notch1 and PTEN expression in non-small cell lung cancer tissues and their relationship with patient prognosis[J]. Shandong Medical Journal, 2022, 62(29): 58-61.
    [11]
    李莉, 赵振慧, 李妍, 等. 克唑替尼靶向治疗间变性淋巴瘤激酶与C-ros原癌基因1-受体酪氨酸激酶融合基因阳性晚期非小细胞肺癌患者的效果分析[J]. 中国医药, 2023, 18(11): 1627-1631.

    LI L, ZHAO Z H, LI Y, et al. The effect of targeted therapy of crizotinib on advanced non-small cell lung cancer patients with anaplastic lymphoma kinase and C-ros oncogene 1-receptor tyrosine kinase fusion gene positive[J]. China Medicine, 2023, 18(11): 1627-1631.
    [12]
    MA Y X, XI C, ZHANG L, et al. Copy number loss in granzyme genes confers resistance to immune checkpoint inhibitor in nasopharyngeal carcinom[J]. J Immunother Cancer, 2021, 9(3): e002014. DOI: 10.1136/jitc-2020-002014.
    [13]
    HURKMANS D P, BASAK E A, SCHEPERS N, et al. Granzyme B is correlated with clinical outcome after PD-1 blockade in patients with stage Ⅳ non-small-cell lung cancer[J]. J Immunother Cancer, 2020, 8(1): e000586. DOI: 10.1136/jitc-2020-000586.
    [14]
    YI M, NIU M K, XU L P, et al. Regulation of PD-L1 expression in the tumor microenvironment[J]. J Hematol Oncol, 2021, 14(1): 10. DOI: 10.1186/s13045-020-01027-5.
    [15]
    FANG W, ZHANG T, DENG S C, et al. PD-L1 promotes colorectal cancer stem cell expansion by activating HMGA1-dependent signaling pathways[J]. Cancer Lett, 2019, 450: 1-13.
    [16]
    牛羊羊, 冯美燕. EGFR与PD-1/PD-L1在非小细胞肺癌中的表达及临床意义研究进展[J]. 癌症进展, 2020, 18(2): 120-123.

    NIU Y Y, FENG M Y. Research progress on the expression and clinical significance of EGFR and PD-1/PD-L1 in non-small cell lung cancer[J]. Oncology Progress, 2020, 18(2): 120-123.
    [17]
    DOROSHOW D B, SANMAMED M F, HASTINGS K, et al. Immunotherapy in non-small cell lung cancer: facts and hopes[J]. Clin Cancer Res, 2019, 25(15): 4592-4602.
    [18]
    张丽柯, 马磊, 史芳瑜, 等. 胃癌组织细胞程序性死亡配体1表达情况和CD8+肿瘤浸润T淋巴细胞密度及其与患者临床病理特征和预后的关系研究[J]. 中国全科医学, 2022, 25(18): 2262-2267.

    ZHANG L K, MA L, XU Q X, et al. Expression of programmed death ligand 1 and density of CD8+ tumor-infiltrating T-lymphocytes in Gastric cancer tissues and their relationship with clinicopathological characteristics and prognosis of patients with gastric cancer[J]. Chinese General Practice, 2022, 25(18): 2262-2267.
    [19]
    王艳, 徐凤霞, 段玮, 等. 蛋白质精氨酸甲基转移酶5和PD-L1在非小细胞肺癌组织中的表达及其对预后的评估价值[J]. 标记免疫分析与临床, 2023, 30(4): 578-582, 694.

    WANG Y, XU F X, LIU X H, et al. The expression and prognostic value of protein arginine methyltransferase 5 and PD-L1 in non-small cell lung cancer[J]. Labeled Immunoassays and Clinical Medicine, 2023, 30(4): 578-582, 694.
    [20]
    姜玲, 林芷伊, 李娜, 等. 非小细胞肺癌PD-1/PD-L1的表达与EGFR突变相关性研究[J]. 中国肺癌杂志, 2021, 24(9): 623-631.

    JIANG L, LIN Z Y, LI NA, et al. Correlation study on expression of PD-1 and PD-L1 in non-small cell lung cancer and epidermal growth factor receptor mutations[J]. Chinese Journal of Lung Cancer, 2021, 24(9): 623-631.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(2)  / Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (37) PDF downloads(2) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return