Volume 22 Issue 11
Nov.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(11): 1872-1875
ZHANG Lie, LING Yingchun, GAO Gangmei. Efficacy of donepezil combined with cognitive rehabilitation in treating Alzheimer's disease based on near-infrared brain function detection[J]. Chinese Journal of General Practice, 2024, 22(11): 1872-1875. doi: 10.16766/j.cnki.issn.1674-4152.003753
Citation: ZHANG Lie, LING Yingchun, GAO Gangmei. Efficacy of donepezil combined with cognitive rehabilitation in treating Alzheimer's disease based on near-infrared brain function detection[J]. Chinese Journal of General Practice, 2024, 22(11): 1872-1875. doi: 10.16766/j.cnki.issn.1674-4152.003753
shu

Efficacy of donepezil combined with cognitive rehabilitation in treating Alzheimer's disease based on near-infrared brain function detection

doi: 10.16766/j.cnki.issn.1674-4152.003753

  • Department of Neurology, Shaoxing Seventh People's Hospital, Shaoxing, Zhejiang 312000, China

Funds:

 2024ZL1138

  • Received Date: 2024-05-18
    Available Online: 2024-12-31
    Abstract
  •   Objective  To investigate the influence of donepezil combined with cognitive rehabilitation on cognitive function, daily living ability, and oxidative stress level of Alzheimer's disease (AD), and explore the efficacy based on near-infrared brain function detection of prefrontal lobe hemoglobin (HbO) level.  Methods  A total of 88 AD patients who were treated in Shaoxing Seventh People's Hospital from June 2023 to January 2024 were included in this study and were divided into a single group and a composite group using a simple random number table method, with 44 cases in each group. The single group was treated with donepezil, while the composite group carried out cognitive rehabilitation therapy on the basis of the single group. The changes in cognitive function [mini-mental state examination (MMSE), AD assessment cognitive subscale (ADAS-Cog)], cerebral prefrontal lobe HbO level, activities of daily living [activity of daily living scale (ADL)], oxidative stress indicators [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px)], and interleukin-6 (IL-6) were compared between groups before and after treatment.  Results  After 8 weeks of treatment, the MMSE score, HbO level in the cerebral prefrontal lobe, and ADL score in the two groups were increased compared with those before treatment (P < 0.05), and the scores and level in the composite group were higher than those in the single group [(25.52±2.23) points vs. (24.37±2.35) points, (3.26±0.21) ×10-2 mmol·L-1·mm vs. (3.12±0.24) ×10-2 mmol·L-1·mm, (82.52±3.25) points vs. (75.37±3.54) points, all P < 0.05]. The ADAS-Cog score in both groups was reduced (P < 0.05), and the score was lower in the composite group than that in the single group [(44.22±5.14) points vs. (46.74±5.35) points, P=0.020]. The levels of SOD and GSH-Px were enhanced in both groups (P < 0.05) while the level of IL-6 in the composite group was declined (P < 0.05), but there were no obvious differences between the two groups (P>0.05).  Conclusion  Based on near-infrared brain function detection, it is found that donepezil combined with cognitive rehabilitation in the treatment of AD can enhance the concentration of cerebral prefrontal lobe HbO, and combined therapy can improve cognitive function and enhance the activities of daily living.

     

    • FullText(HTML)
  • loading
    • References(19)
  • [1]
    汤韫钰, 刘如恩. 阿尔兹海默病的诊断与综合治疗进展[J]. 中国实用神经疾病杂志, 2022, 25(8): 996-1000.

    TANG Y Y, LIU R E. Progress in diagnosis and comprehensive treatment of Alzheimer's disease[J]. Chinese Journal of Practical Nervous Diseases, 2022, 25(8): 996-1000.
    [2]
    王琼, 王国平. 阿尔茨海默病的诊断与治疗[J]. 中华全科医学, 2019, 17(8): 1255-1256. http://www.zhqkyx.net/article/id/18f73bba-8d0a-4fc0-8880-f792d4b6bd77

    WANG Q, WANG G P. Diagnosis and treatment of Alzheimer's disease[J]. Chinese Journal of General Practice, 2019, 17(8): 1255-1256. http://www.zhqkyx.net/article/id/18f73bba-8d0a-4fc0-8880-f792d4b6bd77
    [3]
    张英杰. 盐酸多奈哌齐治疗老年阿尔茨海默病的效果研究[J]. 重庆医学, 2022, 51(S02): 244-246.

    ZHANG Y J. Effect of Donepezil hydrochloride on senile Alzheimer's disease[J]. Chongqing Medicine, 2022, 51(S02): 244-246.
    [4]
    王怡圆, 范晨雨, 王念宏, 等. 常见康复训练在轻度认知障碍中的研究进展[J]. 康复学报, 2024, 34(1): 90-96.

    WANG Y Y, FAN C Y, WANG N H, et al. Research progress of common rehabilitation training methods in mild cognitive impairment[J]. Rehabilitation Medicine, 2024, 34(1): 90-96.
    [5]
    张宇泽, 戴冰, 张惠. 近红外光谱成像在大脑神经认知障碍研究中的应用[J]. 中国医药导报, 2023, 20(14): 34-37, 42.

    ZHANG Y Z, DAI B, ZHANG H. Application of functional near-infrared spectroscopy in the study of brain neurocognitive disorders[J]. China Medical Herald, 2023, 20(14): 34-37, 42.
    [6]
    田金洲, 解恒革, 王鲁宁, 等. 中国阿尔茨海默病痴呆诊疗指南(2020年版)[J]. 中华老年医学杂志, 2021, 40(3): 269-283.

    TIAN J Z, XIE H G, WANG L N, et al. Chinese guideline for the diagnosis and treatment of Alzheimer's disease dementia(2020)[J]. Chinese Journal of Geriatrics, 2021, 40(3): 269-283.
    [7]
    SALIS F, COSTAGGIU D, MANDAS A. Mini-mental state examination: optimal cut-off levels for mild and severe cognitive impairment[J]. Geriatrics (Basel), 2023, 8(1): 12. DOI: 10.3390/geriatrics8010012.
    [8]
    ULBL J, RAKUSA M. Validation of slovenian version of ADAS-Cog for patients with mild cognitive impairment and Alzheimer's disease[J]. Acta Neurol Belg, 2022, 122(3): 695-702. doi: 10.1007/s13760-021-01780-5
    [9]
    TRAMONTANO M, BELLUSCIO V, BERGAMINI E, et al. Vestibular rehabilitation improves gait quality and activities of daily living in people with severe traumatic brain injury: a randomized clinical trial[J]. Sensors(Basel), 2022, 22(21): 8553. DOI: 10.3390/s22218553.
    [10]
    王其琼, 吕俊玲, 胡咏川, 等. 阿尔茨海默病致病机制及治疗药物研究新进展[J]. 中国药学杂志, 2020, 55(23): 1939-1947.

    WANG Q Q, LYU J L, HU Y C, et al. Pathogenesis and new therapeutic drugs of Alzheimer disease[J]. Chinese Pharmaceutical Journal, 2020, 55(23): 1939-1947.
    [11]
    陈杰, 王明哲, 张卓成, 等. 多奈哌齐联合丁苯酞和复方吡拉西坦脑蛋白水解物治疗阿尔兹海默病的临床分析[J]. 老年医学与保健, 2021, 27(5): 1011-1014.

    CHEN J, WANG M Z, ZHANG Z C, et al. Clinical analysis of donepezil and butylphthalide combined with compound piracetam brain protein hydrolysate in the treatment of Alzheimer's disease[J]. Geriatrics & Health Care, 2021, 27(5): 1011-1014.
    [12]
    周园园, 张瑞芬, 李鹏鹏, 等. 微信平台在阿尔茨海默病患者家庭认知康复治疗中的应用[J]. 中国康复医学杂志, 2019, 34(9): 1100-1102.

    ZHOU Y Y, ZHANG R F, LI P P, et al. Application of WeChat platform in family cognitive rehabilitation of patients with Alzheimer's disease[J]. Chinese Journal of Rehabilitation Medicine, 2019, 34(9): 1100-1102.
    [13]
    陈炜, 贾伟华, 蔺芳菊, 等. 认知功能障碍康复诊疗系统对脑梗死后认知功能障碍伴焦虑患者的干预效果研究[J]. 实用心脑肺血管病杂志, 2023, 31(2): 115-119.

    CHEN W, JIA W H, LIN F J, et al. Intervention effect of cognitive dysfunction rehabilitation diagnosis and treatment system on patients with cognitive dysfunction and anxiety after cerebral infarction[J]. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease, 2023, 31(2): 115-119.
    [14]
    姬忠敏, 李道静, 张爱梅. 功能性近红外光谱技术在脑卒中后抑郁及认知障碍中的应用研究进展[J]. 中华神经医学杂志, 2024, 23(2): 202-207.

    JI Z M, LI D J, ZHANG A M. Recent advance in functional near-infrared spectroscopy in post-stroke depression and cognitive impairment[J]. Chinese Journal of Neuromedicine, 2024, 23(2): 202-207.
    [15]
    程奥博, 樊家琦, 刘力慧, 等. 青少年抑郁患者在言语流畅性任务下脑氧合血红蛋白水平的变化[J]. 中华行为医学与脑科学杂志, 2022, 31(7): 629-633.

    CHENG A B, FAN J Q, LIU L H, et al. Changes of brain oxygenated hemoglobin concentration in adolescent patients with depression under speech fluency task[J]. Chinese Journal of Behavioral Medicine and Brain Science, 2022, 31(7): 629-633.
    [16]
    贾建平, 王舒衡. 阿尔茨海默病发病机制及治疗进展[J]. 中风与神经疾病杂志, 2023, 40(5): 387-390.

    JIA J P, WANG S H. Progress in pathogenesis and treatment of Alzheimer's disease[J]. Journal of Apoplexy and Nervous Diseases, 2023, 40(5): 387-390.
    [17]
    于筝, 周东升. 补肾益智方联合多奈哌齐片治疗阿尔茨海默病的疗效及对Aβ、GSH-Px、SOD及MDA的影响[J]. 广东医学, 2019, 40(12): 1798-1802.

    YU Z, ZHOU D S. Curative effect of Bushen Yizhi recipe combined with donepezil tablets in the treatment of Alzheimer's disease and its influence on Aβ, GSH-Px, SOD and MDA[J]. Guangdong Medical Journal, 2019, 40(12): 1798-1802.
    [18]
    袁丹, 王海鹏, 王英鹏, 等. 美金刚联合多奈哌齐对阿尔茨海默病患者认知功能及神经递质的影响[J]. 脑与神经疾病杂志, 2022, 30(2): 71-75.

    YUAN D, WANG H P, WANG Y P, et al. Effect of memantine combined with donepezil on cognitive function and oxidative stress in patients with Alzheimer's disease[J]. Journal of Brain and Nervous Diseases, 2022, 30(2): 71-75.
    [19]
    李瑞天, 赵园园, 蔡灵钰, 等. 盐酸多奈哌齐对阿尔茨海默病患者认知功能及氧化应激水平的影响[J]. 中国医药, 2020, 15(3): 382-385.

    LI R T, ZHAO Y Y, CAI L Y, et al. Effect of donepezil hydrochloride on cognitive function and oxidative stress in patients with Alzheimer disease[J]. China Medicine, 2020, 15(3): 382-385.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (32) PDF downloads(2) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return