Volume 22 Issue 11
Nov.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(11): 1880-1883
SHU Cunhong, ZHANG Yaoping, ZHANG Yuanbin. LASSO regression to identify predictors and model construction for postoperative residual pain in patients with osteoporotic vertebral compression fracture[J]. Chinese Journal of General Practice, 2024, 22(11): 1880-1883. doi: 10.16766/j.cnki.issn.1674-4152.003755
Citation: SHU Cunhong, ZHANG Yaoping, ZHANG Yuanbin. LASSO regression to identify predictors and model construction for postoperative residual pain in patients with osteoporotic vertebral compression fracture[J]. Chinese Journal of General Practice, 2024, 22(11): 1880-1883. doi: 10.16766/j.cnki.issn.1674-4152.003755
shu

LASSO regression to identify predictors and model construction for postoperative residual pain in patients with osteoporotic vertebral compression fracture

doi: 10.16766/j.cnki.issn.1674-4152.003755

  • Department of Spinal Surgery, Fuyang Traditional Chinese Medicine Orthopedics and Trauma Hospital, Hangzhou, Zhejiang 311400, China

Funds:

 2020KY806

  • Received Date: 2024-04-12
    Available Online: 2024-12-31
    Abstract
  •   Objective  To investigate factors of residual pain following percutaneous vertebroplasty (PVP) in patients with osteoporotic vertebral compression fracture (OVCF) and to construct a Nomgram model based on LASSO regression for identifying relevant factors. This aims to provide reference for early identification of high-risk groups for postoperative residual pain.  Methods  A retrospective study was conducted on the efficacy of acceptance commitment therapy combined with a collaborative care model in esophageal cancer patients undergoing radiotherapy and chemotherapy. Clinical data of 60 OVCF patients with residual pain after PVP surgery from January 2022 to December 2023 in Fuyang Traditional Chinese Medicine Orthopedics and Trauma Hospital were included in the residual pain group, while clinical data of 60 patients without residual pain during the same period were included in the no residual pain group. Compare the baseline data and perioperative indicators of the two groups. Utilize LASSO regression to identify relevant risk factors and perform logistic regression analysis to develop a nomogram model with internal validation.  Results  Six potential related factors were screened using the LASSO regression model. The results of logistic regression analysis showed that TLF injury, bone cement leakage, facet joint invasion, and excessive bone cement injection were independent risk factors affecting residual pain in OVCF patients after PVP surgery (OR>1, P < 0.05). In contrast, high BMD T values and significant postoperative vertebral height recovery rate were identified as protective factors (OR < 1, P < 0.05). The constructed Nomgram model exhibited a C-index value of 0.926, indicating strong discrimination. The overall trend of the calibration curve was close to the ideal curve. The ROC curve analysis predicted an AUC of 0.926 for residual pain after PVP in OVCF patients, indicating high predictive validity.  Conclusion  A Nomogram model incorporating BMD T value, TLF injury, bone cement leakage, facet joint invasion, bone cement injection volume, and postoperative vertebral height recovery rate, can effectively predict the risk of residual pain in OVCF patients after PVP surgery.

     

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    • References(16)
  • [1]
    ALSOOF D, ANDERSON G, MCDONALD C L, et al. Diagnosis and management of vertebral compression fracture[J]. Am J Med, 2022, 135(7): 815-821. doi: 10.1016/j.amjmed.2022.02.035
    [2]
    安忠诚, 陈晨, 董黎强, 等. 经皮椎体后凸成形术后邻近节段再骨折的危险因素分析[J]. 中华全科医学, 2022, 20(4): 591-593, 712. doi: 10.16766/j.cnki.issn.1674-4152.002407

    AN Z C, CHEN C, DONG L Q, et al. Risk factors for adjacent segment refracture after percutaneous kyphoplasty[J]. Chinese Journal of General Practice, 2022, 20(4): 591-593, 712. doi: 10.16766/j.cnki.issn.1674-4152.002407
    [3]
    HAIBIER A, YUSUFU A, LIN H, et al. Effect of different cement distribution in bilateral and unilateral percutaneous vertebro plasty on the clinical efficacy of vertebral compression fractures[J]. BMC Musculoskelet Disord, 2023, 24(1): 908. DOI: 10.1186/s12891-023-06997-4.
    [4]
    中国康复医学会骨质疏松预防与康复专业委员会. 骨质疏松性椎体压缩骨折诊治专家共识(2021版)[J]. 中华医学杂志, 2021, 101(41): 3371-3379. doi: 10.3760/cma.j.cn112137-20210625-01436

    Chinese Rehabilitation Medicine Association Osteoporosis Prevention and Rehabilitation Professional Committee. Expert consensus on the diagnosis and treatment of osteoporotic vertebral compression fractures (2021 Edition)[J]. National Medical Journal of China, 2021, 101(41): 3371-3379. doi: 10.3760/cma.j.cn112137-20210625-01436
    [5]
    中华医学会放射学分会介入学组. 经皮椎体成形术操作技术专家共识[J]. 中华放射学杂志, 2014, 48(1): 6-9.

    Interventional Group of Radiology Branch of Chinese Medical Association. Expert consensus on percutaneous vertebroplasty operation technology[J]. Chinese Journal of Radiology, 2014, 48(1): 6-9.
    [6]
    PEDROSA E, SILVA M, LOBO A, et al. Is the asa classification universal?[J]. Turk J Anaesthesiol Reanim, 2021, 49(4): 298-303. doi: 10.5152/TJAR.2021.103
    [7]
    LIN M M, WEN X M, HUANG Z W, et al. A nomogram for predicting residual low back pain after percutaneous kyphoplasty in osteoporotic vertebral compression fractures[J]. Osteoporos Int, 2023, 34(4): 749-762. doi: 10.1007/s00198-023-06681-2
    [8]
    WANG R J, XU Y Y, MA X L. Risk factors and strategies for recovery quality, postoperative pain, and recurrent fractures between percutaneous kyphoplasty and percutaneous vertebroplasty in elderly patients with thoracolumbar compression fractures: a retrospective comparative cohort study[J]. Ann Transl Med, 2023, 11(2): 122. DOI: 10.21037/atm-22-6475.
    [9]
    陈晨, 安忠诚, 吴连国, 等. 椎体强化术后早期与后期残留腰背痛的原因分析[J]. 中国骨伤, 2022, 35(8): 724-731.

    CHEN C, AN Z C, WU L G, et al. Analysis of the causes of residual back pain in the early and late stages after percutaneous vertebral augmentation[J]. China Journal of Orthopaedics and Traumatology, 2022, 35(8): 724-731.
    [10]
    付海军, 冯毅, 武太勇, 等. 经皮椎体成形术椎间盘骨水泥渗漏对相邻椎体生物力学影响的有限元分析[J]. 北京生物医学工程, 2022, 41(2): 140-147.

    FU H J, FENG Y, WU T Y, et al. Finite element analysis of biomechanical effect of intervertebral disc cement leakage on adjacent vertebrae after percutaneous vertebroplasty[J]. Beijing Biomedical Engineering, 2022, 41(2): 140-147.
    [11]
    郭存良, 崔凯莹, 郝延科. 不同骨水泥注入量对经皮椎体后凸成形术治疗骨质疏松性椎体压缩骨折疗效的影响[J]. 临床骨科杂志, 2022, 25(2): 153-156.

    GUO C L, CUI K Y, HAO Y K, et al. Effect of different volume of bone cement injection on the efficacy of percutaneous kyphoplas-ty in the treatment of osteoporotic vertebral compression fractures[J]. Journal of Clinical Orthopedics, 2022, 25(2): 153-156.
    [12]
    LI Y, YUE J X, HUANG M Y, et al. Risk factors for postoperative residual back pain after percutaneous kyphoplasty for osteoporotic vertebral compression fractures[J]. Eur Spine J, 2020, 29(10): 2568-2575. doi: 10.1007/s00586-020-06493-6
    [13]
    PAYO-OLLERO J, LLOMBART-BLANCO R, VILLAS C, et al. Vertebral body height changes in acute symptomatic osteoporotic vertebral compression fractures treated with vertebral cement augmentation-which factors affect vertebral body height during follow-up? A multiple linear regression study[J]. Geriatrics (Basel), 2022, 7(6): 142. DOI: 10.3390/geriatrics7060142.
    [14]
    ARGYROU C, KARLAFTI E, LAMPROPOULOU-ADAMIDOU K, et al. Effect of calcium and vitamin d supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia[J]. J Musculoskelet Neuronal Interact, 2020, 20(1): 12-17.
    [15]
    吴海波, 禹志军, 白曼莫. 骨质疏松性椎体压缩骨折椎体成形修复效果与骨水泥注入量及弥散程度的关系[J]. 中国组织工程研究, 2020, 24(16): 2473-2477.

    WU H B, YU Z J, BAI M M. Correlation of percutaneous vertebroplasty effect on osteoporotic vertebral compression fracture with injection amount and dispersion degree of bone cement[J]. Chinese Journal of Tissue Engineering, 2020, 24(16): 2473-2247.
    [16]
    徐军平, 王莉, 朱昊强, 等. 正位透视法在经皮椎体成形术治疗骨质疏松性椎体压缩骨折中的应用[J]. 临床骨科杂志, 2023, 26(4): 475-479.

    XU J P, WANG L, ZHU H Q, et al. Application of anteroposterior fluoroscopy in the treatment of osteoporotic vertebral compres-sion fracture treated by percutaneous vertebroplasty[J]. Journal of Clinical Orthopedics, 2023, 26(4): 475-479.
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